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Life Extension Magazine

Page: 123

LE Magazine May 2002

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Page 3 of 3

References

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1. J Gerontol. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. A Biol Sci Med Sci 2000 Jun;55(6):B280-5.

2. Rimm EB, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993 May 20;328(20):1450-6.

3. Stampfer MJ, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993 May 20;328(20):1444-9.

4. Stephens NG, et al. Randomized controlled trial of vitamin E in patients with coronary disease. Lancet 1996 Mar 23;347(9004):781-6.

5. Meagher EA, et al. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA 2001 Mar 7;285(9):1178-82.

6. Hodis HN, et al. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 1995 Jun 21;273(23):1849-54.

7. Yusuf S. Clinical, public health, and research implications of the Heart Outcomes Prevention Evaluation (HOPE) Study. Eur Heart J 2001 Jan;22(2):103-4.

8. Regnstrom J, et al. Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease. Am J Clin Nutr 1996 Mar;63(3):377-85.

9. Kushi LH, et al. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996 May 2;334(18):1156-62.

10. Knekt P, et al. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994 Jun 15;139(12):1180-9.

11. Bieri J G . Sources and consumption of antioxidants in the diet. J Am Oil Chem Soc 61 (12). 1984. 1917-1918. 1984.

12. Handelman GJ, et al. Oral alpha tocopherol supplements decrease plasma gamma tocopherol levels in humans. J Nutr 1985 Jun;115(6):807-13.

13. Ohrvall M, et al. Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients. J Intern Med 1996 Feb;239(2):111-7.

14. Christen S, et al. gamma tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha tocopherol: physiological implications. Proc Natl Acad Sci U S A 1997 Apr 1;94(7):3217-22.

15. Cooney RV, et al. gamma tocopherol detoxification of nitrogen dioxide: superiority to alpha tocopherol. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1771-5.

16. Adachi H, et al. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 2000 Jun;55(6):B280-5.

17. Tomeo AC, et al. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 1995 Dec;30(12):1179-83.

18. Parker RA, et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 1993 May 25;268(15):11230-8.

19. Qureshi AA, et al. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am J Clin Nutr 1991 Apr;53(4 Suppl):1021S-1026S.

20. Qureshi A.A., et al. Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolomic humans. Journal of Nutritional Biochemistry ( J. NUTR. BIOCHEM. ) (United States) 1997, 8/5 (290-298).

21. Brown G, et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 1990 Nov 8;323(19):1289-98.

22. Maciejko JJ, et al. Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N Engl J Med 1983 Aug 18;309(7):385-9.

23. Barbir M, et al. High prevalence of hypertriglyceridaemia and apolipoprotein abnormalities in coronary artery disease. Br Heart J 1988 Nov;60(5):397-403.

24. Jiang Q, et al. gamma tocopherol and its major metabolite, in contrast to alpha tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci U S A 2000 Oct 10;97(21):11494-9.

25. Saldeen T, et al. Differential effects of alpha- and gamma tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesis. J Am Coll Cardiol 1999 Oct;34(4):1208-15.

26. Qureshi AA, et al. Synergistic effect of tocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans. J Nutr Biochem 2001 Jun;12(6):318-329.

27. Watkins T, et al. gamma tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. Lipids 1993 Dec;28(12):1113-8.

28. Kline K, et al. Vitamin E: mechanisms of action as tumor cell growth inhibitors. J Nutr 2001 Jan;131(1):161S-163S.

29. Elson CE, et al. The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables. J Nutr 1994 May;124(5):607-14.

30. Mo H, et al. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J Nutr 1999 Apr;129(4):804-13.

31. He L, et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 1997 May;127(5):668-74.

32. Block G, et al. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992;18(1):1-29.

33. Elson CE, et al. Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. Proc Soc Exp Biol Med 1999 Sep;221(4):294-311.

34. Elson CE. Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease. .J Nutr 1995 Jun;125(6 Suppl):1666S-1672S.

35. Rahmat A, et al. Long-term administration of tocotrienols and tumor-marker enzyme activities during hepatocarcinogenesis in rats. Nutrition 1993 May-Jun;9(3):229-32.

36. Ong FB, et al. Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. Comp Biochem Physiol C 1993 Sep;106(1):237-40.

37. He L, et al. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 1997 May;127(5):668-74.

38. Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 1995 Dec;30(12):1139-43.

39. Nesaretnam K, et al. Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 1998 May;33(5):461-9.

40. Nesaretnam K, et al. Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. Int J Food Sci Nutr 2000;51 Suppl:S95-103.

41. Guthrie N, et al. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. J Nutr 1997 Mar;127(3):544S-548S.

42. Yu W, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 1999;33(1):26-32.

43. McIntyre BS, et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med 2000 Sep;224(4):292-301.

44. McIntyre BS, et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 2000 Feb;35(2):171-80.

45. Osborne CK, et al. Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl Cancer Inst 1995 May 17;87(10):746-50.

46. Moyad MA, et al. Vitamin E, alpha- and gamma tocopherol, and prostate cancer. Semin Urol Oncol 1999 May;17(2):85-90.

47. Helzlsouer KJ, et al. Association between alpha tocopherol, gamma tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst 2000 Dec 20;92(24):2018-23.

48. Steinberg D, et al. Lipoproteins and the pathogenesis of atherosclerosis. Circulation 1989 Sep;80(3):719-23.

49. Yla-Herttuala S, et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989 Oct;84(4):1086-95.

50. Cooney RV, et al. gamma tocopherol detoxification of nitrogen dioxide: superiority to alpha tocopherol. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1771-5.

51. Christen S, et al. gamma tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha tocopherol: physiological implications. Proc Natl Acad Sci U S A 1997 Apr 1;94(7):3217-22.

52. Packer L, et al. Molecular aspects of alpha tocotrienol antioxidant action and cell signalling. J Nutr 2001 Feb;131(2):369S-73S.

53. Serbinova E, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha tocopherol and alpha tocotrienol. Free Radic Biol Med 1991;10(5):263-75.

54. Serbinova E, et al. Palm oil vitamin E protects against ischemia/reperfusion injury in the isolated perfused Langendorff heart. Malaysia Nutrition Research ( NUTR. RES. ) (United States) 1992 , 12/SUPPL. (S203-S215).

55. Kamat JP, et al. Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 1995 Aug 11;195(3):179-82

56. Kamat JP, et al. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol Cell Biochem 1997 May;170(1-2):131-7.

57. Cooney RV, et al. gamma tocopherol detoxification of nitrogen dioxide: superiority to alpha tocopherol. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1771-5.

58. Handelman GJ, et al. Oral alpha tocopherol supplements decrease plasma gamma tocopherol levels in humans. J Nutr 1985 Jun;115(6):807-13.

59. Wechter WJ, et al. A new endogenous natriuretic factor: LLU-alpha. Proc Natl Acad Sci U S A 1996 Jun 11;93(12):6002-7.

60. Hattori A, et al. Production of LLU-alpha following an oral administration of gamma tocotrienol or gamma tocopherol to rats. Biol Pharm Bull 2000 Nov;23(11):1395-7.

61. Hattori A, et al. Occurrence and determination of a natriuretic hormone, 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman, in rat plasma, urine, and bile. Anal Biochem 2000 Jun 1;281(2):209-15.

62. Newaz MA, et al. Effect of gamma tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). Clin Exp Hypertens 1999 Nov;21(8):1297-313.

63. Bendich A, et al. Safety of oral intake of vitamin E. Am J Clin Nutr 1988 Sep;48(3):612-9.

64. Diplock AT. Safety of antioxidant vitamins and beta-carotene. Am J Clin Nutr 1995 Dec;62(6 Suppl):1510S-1516S.

65. Meyers DG, et al. Safety of antioxidant vitamins. Arch Intern Med 1996 May 13;156(9):925-35.

66. Corrigan JJ Jr, et al. Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency. Am J Clin Nutr 1981 Sep;34(9):1701-5.

67. Brown KM, et al. Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation. Am J Clin Nutr 1997 Feb;65(2):496-502.



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