1. Centers fror Disease Control and Prevention. About Cardiovascular Disease. Available at: http://www.cdc.gov/cvh/aboutcardio.htm Accessed June 5, 2003
2. Healthy People 2010. Chapter 12. Heart Disease and Stroke. Available at: http://hin.nhlbi.nih.gov/cvd_frameset.htm. Accessed on June 5, 2003.
3. Appel LA, et al. Effects of dietary patterns on blood pressure. N Engl J Med. Apr 17;336 (16):1117-1124.
4. Sacks FM, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. 2001 Jan 4;344(1) 3-10.
5. Obarzanek E, et al. Effects on blood lipids of a blood pressure-lowering diet; the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr. 2001 Jul;74(1):80-89.
6. Mozaffarian D, et al. Cardiac benefits of fish consumption may depend on the type of fish meal consumed: The Cardiovascular Health Study. Circulation. 2003 Mar 18;107(10):1372-1377.
7. Auder J, et al. C-reactive protien and coronary artery disease. Jpn Heart J. 2002 Nov;43(6):607-619.
8. Ridker PNM, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002 Nov 14;347(20):1557-1565.
9. Speidl WS, et al. High-sensitivity C-reactive protein in the prediction of coronary events in patients with premature coronary artery dis- ease. Am Heart J. 2002 DSep;144(3):449-455.
10. Ridker PM, et al. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardio- vascular disease. Circulation. 2001 Apr 3; 103(13):1813-1818.
11. Ridker PM, et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000 Mar 23;(342)12:836-843.
12. Kuller LH, et al. Relationship of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Am J Epidemiol. 1996;144:537-547.
13. Mendall MA, et al. C-reactive protein relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men. Eur Heart J. 2000Oct;21(19):1584-1590.
14. Ridker PM, et al. Plasma concentration of C- reactive protein and risk of developing periph- eral vascular disease. Circulation. 1998 Feb 10;97(5):425-428.
15. De Bree A, et al. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev. 2002 Dec;54(4):599-618.
16. Kelly PJ, et al. Homocysteine, MTHFR677C --T polymorphism and risk of ischemic stroke: results of a meta-analysis. Neurology. 2002 Aug 27;59(4):529-536.
17. Kuan YM, et al. Homocysteine: An aetiological contributor to peripheral vascular arterial dis ease. ANZ J Surg. 2002 Sep;72(9):668-671.
18. Vasan RS, et al. Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA 2003 Mar 12;89(10):1251-1257.
19. Retterstol L, et al. Plasma total homocysteine levels and prognosis in patient with previous premature myocardial infarction: a 10-year follow-up study. JIntern Med. 2003 Mar;253(3):284-292.
20. Nehler MR, et al. Homocysteinemia as a risk factor for atherosclerosis: a review. Cardiovas Surg. 1997;5:559-567.
21. Chambers JC, et al. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentra- tions of free plasma homocysteine. Circulation. 2000 Nov 14;102(20):2479-2483.
22. Selhub J, et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev. 2000;28(1-4):117-145.
23. Verhoaf P, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vita- mins B6, B12 and folate. Am J Epidemiol. 1996 May 1;143(9):845-859.
24. Abby SL, et al. Homocysteine and cardiovascu- lar disease. J Am Board Fam Pract. 1998 Sep- Oct;11(5):391-398.
25. Undas A, et al. Treatment of hyperhomocys- teinemia with folic acid and vitamins B12 and B6 attenuates thrombin generation. Thromb Res. 1999 Sep 15;95(6):281-288.
26. Chao CL, et al. Effect of short-term vitamin (folic acid, vitamins B6 and B12) administra- tion on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia. Am J Cardio. 1999 Dec 1;84(11):1359-1361.
27. Marchioli R, et al. Early protection against sud- den death by n-3 polyunsaturated fatty acids. Circulation. 2002 Apr 23;105(16):1897-1903.
28. Castano G, et al. Effects of policosanol in older patients with type II hypercholesterolemia and high coronary artery risk. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M186-192.
29. Castano G, et al. Comparisons of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholes- terolemia. Drugs Aging 2003;20(2):153-163.
30. Tran MT, et al. Role of coenzyme Q10 in chron- ic heart failure, angina and hypertension. Pharmacotherapy. 2001 Jul;21(7):797-806.
31. Baggio E, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunc- tive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med. 1994;15 Suppl:s287-294.
32. Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult. Available at:http://www.acc.org/
clinical/guidelines/failure/hf_index.htm. Accessed May 25, 2003.
33. Esch PM, et al. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with ser- rapeptase-a prospective study. Fortschr Med. 1989 Feb 10;107(4):67-8,71-2.
34. Majima Y, et al. The effect of an orally admin- istered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otohinolaryngol. 1988;244(6):355-359.
35. Mazzone A, et al. Evaluation of Serratia pepti- dase in acute or chronic inflammation of otorhinolaryngology pathology: a multicenter, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-388.
36. Brewer Science Library website. Available at: http://www/mwt.net/~drbrewer/niep_art.htm. Accessed May 28, 2003.
37. Channer KS, et al. Cardiovascular effects of testosterone: implications of the “male menopause?” Heart 2003 Feb;89(2):121-122.
38. English KM, et al. Men with coronary artery disease have lower levels of testosterone than those with normal coronary angiograms. Eur Heart J. 2000 Jun;21(11):890-894.
39. English KM, et al. Low-dose transdermal testosterone therapy improves angina thresh- old in men with chronic stable angina: A ran- domized, double-blind, placebo-controlled study. Circulation. 2000 Oct 17;102(16):1906-1911.