1. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20.
2. Stewart JR, Artime MC, O’Brian CA. Resveratrol: a candidate nutritional substance for prostate cancer prevention. J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
3. Dhanalakshmi S, Agarwal R, Agarwal C. Inhibition of NF-kappaB pathway in grape-seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J Oncol. 2003 Sep;23(3):721-7.
4. Aziz MH, Kumar R, Ahmad N. Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol. 2003 Jul;23(1):17-28.
5. Chemoprevention Working Group to the American Association for Cancer Research. Prevention of cancer in the next millennium: report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res. October 1, 1999;59(19):4743-58.
6. de Santi C, Pietrabissa A, Mosca F, Pacifici GM. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica. 2000 Nov;30(11):1047-54.
7. ElAttar TM, Virji AS. Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 1999 Feb;10(2):187-93.
8. Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001 May 24;20(23):2927-36.
9. Tyagi A, Agarwal R, Agarwal C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiprolifera- tion and apoptosis. Oncogene. 2003 Mar 6;22(9):1302-16.
10. Xing N, Chen Y, Mitchell SH, Young CY. Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14.
11. Kampa M, Hatzoglou A, Notas G, et al. Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Nutr Cancer. 2000;37(2):223-33.
12. Ulsperger E, Hamilton G, Raderer M, et al. Resveratrol pretreatment desensitizes AHTO-7 human osteoblasts to growth stimulation in response to carcinoma cell supernatants. Int J Oncol. 1999 Nov;15(5):955-9.
13. Milner J, Allison R, Elliott J, et al. Opportunities and challenges for future nutrition research in cancer prevention: A panel discussion. J. Nutr. 2003;133:2502S- 2504S.
14. Meng Q, Yuan F, Goldberg ID, Rosen EM, Auborn K, Fan S. Indole-3-carbinol is a neg- ative regulator of estrogen receptor-alpha signaling in human tumor cells. J Nutr. 2000 Dec;130(12):2927-31.
15. Chang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF. Cytostatic and antiestrogenic effects of 2-(indol-3- ylmethyl)-3,3’-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol. 1999 Sep 1;58(5):825-34.
16. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3’-diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003 Jun 6;278(23):21136-45. Epub 2003 Mar 27.
17. Jellinck PH, Newcombe AM, Forkert PG, Martucci CP. Distinct forms of hepatic androgen 6 beta-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile. J Steroid Biochem Mol Biol. 1994 Nov;51(3-4):219-25.
18. Lu R, Serrero G. Resveratrol, a natural product derived from grape, exhibits anti-estrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304.
19. Serrero G, Lu R. Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid Redox Signal. 2001 Dec;3(6):969-79.
20. Mitchell SH, Zhu W, Young CY. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Cancer Res. 1999 Dec 1;59(23):5892-5.
21. Hsieh TC, Wu JM. Grape-derived chemo preventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism. Anticancer Res. 2000 Jan-Feb;20(1A):225-8.
22. Narayanan BA, Narayanan NK, Re GG, Nixon DW. Differential expression of genes induced by resveratrol in LNCaP cells: P53- mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
23. Li Y, Li X, Sarkar FH. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. J Nutr. 2003 Apr;133(4):1011-9.
24. Plant compound kills lung cancer cells. Reuters Health. February 2, 2003. Available at: http://188.8.131.52/HealthNews/ reuters/NewsStory0221200318.htm. Accessed February 26, 2004.
25. Chun KH, Kosmeder JW 2nd, Sun S, et al. Effects of deguelin on the phosphatidylinos- itol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst. 2003 Feb 19;95(4):291-302.
26. Udeani GO, Gerhauser C, Thomas CF, et al. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 1997 Aug 15;57(16):3424-8.
27. Murillo G, Salti GI, Kosmeder JW 2nd, Pezzuto JM, Mehta RG. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer. 2002 Dec;38(18):2446-54.
28. Gerhauser C, Lee SK, Kosmeder JW, et al. Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res. 1997 Aug 15;57(16):3429-35.
29. Fang N, Casida JE. Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4.
30. Schneider Y, Vincent F, Duranton B, et al. Antiproliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett. 2000 Sep 29;158(1):85-91.
31. Wolter F, Turchanowa L, Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis. 2003 Mar;24(3):469-74.
32. Malt RA, Kingsnorth AN, Lamuraglia GM, Lacaine F, Ross JS. Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas. Adv Enzyme Regul. 1985;24:93-102.
33. Bachrach U, Shayovitz A, Marom Y, Ramu A, Ramu N. Ornithine decarboxylase—a predictor for tumor chemosensitivity. Cell Mol Biol (Noisy-le-grand). 1994 Nov;40(7):957-64.
34. Hudson EA, Howells LM, Gallacher-Horley B, Fox LH, Gescher A, Manson MM. Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line. BMC Cancer. 2003 Jan 14;3(1):2.
35. Sharma S, Stutzman JD, Kelloff GJ, Steele VE. Screening of potential chemopreventive agents using biochemical markers of car- cinogenesis. Cancer Res. 1994 Nov 15;54(22):5848-55.
36. Stellman SD, Takezaki T, Wang L, et al. Smoking and lung cancer risk in American and Japanese men: an international case- control study. Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1193-9.
37. Wynder EL, Taioli E, Fujita Y. Ecologic study of lung cancer risk factors in the U.S. and Japan, with special reference to smok- ing and diet. Jpn J Cancer Res. 1992 May;83(5):418-23.
38. Lee IP, Kim YH, Kang MH, Roberts C, Shim JS, Roh JK. Chemopreventive effect of green tea (Camellia sinensis) against cigarette smoke-induced mutations (SCE) in humans. J Cell Biochem Suppl. 1997;27:68-75.
39. Zhao J, Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3’-gallate as the most effective antioxidant constituent. Carcinogenesis. 1999 Sep;20(9):1737-45.
40. Dubuisson JG, Dyess DL, Gaubatz JW. Resveratrol modulates human mammary epithelial cell O-acetyltransferase, sulfo transferase, and kinase activation of the het- erocyclic amine carcinogen N-hydroxy-PhIP. Cancer Lett. 2002 Aug 8;182(1):27-32.
41. Damianaki A, Bakogeorgou E, Kampa M, et al. Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem. 2000 Jun 6;78(3):429-41.
42. Baek SJ, Wilson LC, Eling TE. Resveratrol enhances the expression of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis. 2002 Mar;23(3):425-34.
43. Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst. 2000 Jan 5;92(1):61-8.
44. Jain MG, Hislop GT, Howe GR, Ghadirian P. Plant foods, antioxidants, and prostate cancer risk: findings from case-control stud- ies in Canada. Nutr Cancer. 1999;34(2):173-84.
45. Rodler I, Zajkas G. Hungarian cancer mortality and food availability data in the last four decades of the 20th century. Ann Nutr Metab. 2002; 46(2):49-56.
46. Kolonel LN, Hankin JH, Whittemore AS, et al. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):795-804.
47. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer. 2002;42(1):1-9.
48. Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL. Dairy products, calcium, and prostate cancer risk in the Physicians’ Health Study. Am J Clin Nutr. 2001 Oct;74(4):549-54.
49. Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willet WC, Giovannucci E. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control. 2001 Aug;12(6):557-67.
50. Veierod MB, Laake P, Thelle DS. Dietary fat intake and risk of prostate cancer: a prospective study of 25,708 Norwegian men. Int J Cancer. 1997 Nov 27;73(5):634-8.
51. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst. 1993 Oct 6;85(19):1571-9.
52. Willett W. Lessons from dietary studies in Adventists and questions for the future. Am J Clin Nutr. 2003 Sep;78(3 Suppl):539S-543S.
53. Mettlin C, Selenskas S, Natarajan N, Huben R. Beta-carotene and animal fats and their relationship to prostate cancer risk. A case-control study. Cancer. 1989 Aug 1;64(3):605-12.
54. Ankley GT, Jensen KM, Makynen EA, et al. Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead min- now. Environ Toxicol Chem. 2003 Jun;22(6):1350-60.
55. Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone- binding globulin. Endocrinology. 1984 Jun;114(6):2100-6.
56. Skowronski RJ, Peehl DM, Feldman D. Vitamin D and prostate cancer: 1,25 dihy- droxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology. 1993 May;132(5):1952-60.
57. Reiling BA, Johnson DD. Effects of implant regimens (trenbolone acetate-estradiol administered alone or in combination with zeranol) and vitamin D3 on fresh beef color and quality. J Anim Sci. 2003 Jan;81(1):135-42.
58. Globocan 2000: cancer incidence, mortality and prevalence worldwide [CD-ROM]. International Agency for Research on Cancer, World Health Organization; 2001.