Whole Body Health Sale

Life Extension Magazine

Top Ten Recommendations

1: Life Extension Mix

2: Life Extension Super Booster

3: Coenzyme Q10

4: Mitochondrial Energy Optimizer

5: Cognitex

6: Super EPA/DHA with Sesame Lignans

7: Enhanced Natural Prostate with Cernitin (Men)

7: Bone Restore (Women)

8: Restoring Youthful Hormone Balance

9: S-adenosyl-methionine (SAMe)

10: Aspirin

Life Extension Mix
Multivitamin-Mineral-Herbal-Amino Acid Formula

DOSAGE: 3 tablets with breakfast; 3 tablets with lunch; 3 tablets with dinner. (Also available in capsule and powder form.)

Public service campaigns are encouraging people to eat more fruits and vegetables to protect against degenerative disease. Despite years of media publicity, an AC Nielsen poll released August 24, 2004 reported that 85% of Americans are not even eating the minimum recommendation of five servings of fruits and vegetables per day. Those who do report eating some produce often fail to consume the yellow and purple colored plants that are such critical components of a disease prevention program.

Life Extension Mix™ contains 92 unique vegetable, fruit, and herbal extracts along with high quantities of amino acids, vitamins, minerals, and special antioxidants. The Life Extension Mix™ formula is fortified with botanical extracts that help to maintain healthy cells via physiological processes separate from traditional antioxidants. Consumption of these types of plants is being recommended based on research emanating from the most prestigious medical centers in the world.

Standardized Green Tea Extract
The Life Extension Foundation introduced green tea extract as a supplement in 1993 based on epidemiological studies showing that those who consumed green tea had much lower incidences of common degenerative disorders. Over the past 11 years, there have been more positive studies about the health benefits of green tea than any other nutrient.

Scientists have looked at the active “polyphenol” constituents of green tea and have found that they possess remarkable biological activity at the cellular level. Scientists have also identified multiple mechanisms by which green tea extract protects against undesirable cell propagation, LDL oxidation, neuronal peroxidation, and a host of other adverse structural and functional age-related changes.1-7

The new Life Extension Mix™ provides 325 mg of a decaffeinated green tea extract that is standardized to contain 302 mg of the polyphenols that is attributed to green tea’s health benefits.

Members who have been supplementing with one Super Green Tea Extract capsule a day can now eliminate that supplement. The amount of polyphenols (including EGCG) in the new Life Extension Mix™ is equivalent to drinking about 3-6 cups of green tea per day.8

More Vegetable Extracts
Luteolin is a flavonoid found in parsley, artichoke, basil, celery, and other foods. When measured against 27 other flavonoids, luteolin had the second most anti-proliferative activity against undesirable cell colonies.9

One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin’s ability to suppress excess levels of dangerous inflammatory inducers such as interleukin-6, tumor necrosis factor-alpha, and nuclear factor-kappa beta.10-12

The previous version of Life Extension Mix™ provided between 1.5-4 mg of luteolin per daily dose. The new Life Extension Mix™ contains a standardized dose of 8 mg of luteolin, which is two-to-five times more than what members where obtaining before.

Broccoli is touted as one of the most important vegetables to protect against the formation of undesirable cell colonies. Broccoli contains several active constituents, with sulphoraphane being the most significant because of its unique detoxification and DNA protecting effects. The new Life Extension Mix™ provides a concentrated broccoli mixture that provides standardized extracts of sulphoraphane and glucosinolates, two compounds attributed to broccoli’s multiple protective benefits. Broccoli is also a natural source of gene protecting chlorophyll.13-21

D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli, and brussels sprouts.

D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body22-24 The daily dose of Life Extension Mix™ provides 200 mg of D-glucarate.

Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula, while the carotenoid alpha carotene has demonstrated antioxidant activity far greater than beta-carotene. Lycopene from tomatoes has shown potent effects in reducing LDL oxidation inhibiting undesirable prostate cell propagation.25-29 Life Extension Mix™ contains 60 times more lutein and 10 times more lycopene compared to Centrum®. Most multivitamin supplements provide no vegetable extracts whatsoever.

More Fruit Extracts
Life Extension Mix™ is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to provide healthy circulation throughout the body and protect against DNA alterations.

Ellagic acid is a detoxifying agent found in raspberries, strawberries, and other fruit. Ellagic acid has demonstrated DNA-protecting properties, including the ability to bind to toxins and neutralize them. Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. Studies show that people who consume diets high in fruits that contain ellagic acid have lower rates of undesirable cell colony formation.30-32 Life Extension Mix™ contains a raspberry and pomegranate fruit extract to deliver 50 mg of ellagic acid in each daily dose.

The media has publicized the multiple benefits of fruits such as blueberry, blackberry, cranberry, plums, strawberry, and watermelon. The new Life Extension Mix™ has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body.

Olive oil consumption is one of the important factors behind the health benefits of the “Mediterranean Diet.”33-34 Researchers have recently discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.35-36 Olive polyphenols have been the subject of numerous in vitro, in vivo, and human studies pointing toward their benefits in many different areas, including protecting against LDL oxidation, suppressing free radicals, and stabilizing cell membranes.37-39 The new Life Extension Mix™ contains a high concentration of olive juice extract standardized to contain 8% of the best-documented polyphenol called hydroxytyrosol.33 The amount of hydroxytyrosol in the daily dose of Life Extension Mix™ is equivalent to drinking over 6 ounces of olive oil a day.40-41

Sesame Lignans Enhance the Effects of Vitamin E
Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.42,43 Sesame lignans increase the benefits of fish oils, decrease LDL oxidation, inhibit lipid peroxidation, maintain healthy cholesterol/LDL levels in humans, and provide many other benefits.44-47

The new Life Extension Mix™ provides 10 mg of a sesame lignan extract to not only provide the direct benefits of the lignans, as well as augment the effects of vitamin E and other nutrients in the body such as gamma tocopherol and gamma linolenic acid (GLA). The remarkable findings about sesame lignans are explained throughout this special issue of Life Extension magazine.

Maintaining Healthy Blood Glucose Levels
Chromium, along with magnesium and biotin, are nutrients required to maintain optimal blood sugar levels. The new Life Extension Mix™ provides 500 mcg of chromium (compared to 200 mcg in the previous version), a better absorbable form of magnesium, and the same high potency of biotin. A review of studies showing benefits to chromium supplementation reveals that doses exceeding 200 mcg a day is required for optimal effects.48-53

More Vitamin D3
Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to create toxicity in a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density and protecting against the formation of undesirable cell colonies.54-59 In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, the new Life Extension Mix™ provides 800 IU of vitamin D3 per daily dose (compared to 400 IU in the previous version).

The Most Complete Multi-Nutrient Formula
Life Extension Mix™ saves time and money by combining the most popular nutrient supplements into one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements, and much more that would be required to achieve the same effects.

Life Extension Mix™ supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, along with plant extracts that enhance beneficial DNA methylation patterns, help support cellular DNA, and help prevent the oxidation of LDL that contributes to the buildup of deposits in the endothelial lining.

Life Extension Mix™ is the cornerstone of a comprehensive supplement program because it provides so many well-studied nutrients. If you are on a budget, the Life Extension Mix™ provides the best “cost-per-milligram” value.

Turn to the next page for a complete description of the new Life Extension Mix™ formula.

More Info on Life Extension Mix

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1. Fassina, G, Vene, R, Morini, M, et al. Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallcatechin-3-gallate. Clin. Cancer Res. 2004 Jul 15; 10(14):4865-73.

2. Yang, CS, Chung, JY, Li, C, et al. Mechanisms of inhibition of carcinogenesis by tea. Biofactors 2000;13:(1-4):73-9.

3. Fujiki, H. Two stages of cancer prevention with green tea. J. Cancer Res. Clin. Oncol. 1999 Nov;125(11):589-97.

4. Xu, JZ, Yeung, SY, Chang, Q et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br. J. Nutr. 2004 Jun;91(6):873-81.

5. Miyazawa, T. Absorption, metabolism and antioxidative effects of tea catechins in humans. Biofactors 2000;13(1-4):55-9.

6. Xie, D, Liu, G, Zhu, G, et al. [-]-Epigallocatechin-3-gallate protects cultured spiral ganglion cells from H202-induced oxidizing damage. Acta Otolaryngol. 2004 May;124(4): 464-70.

7. Beliveau, R, Gingras, D. Green tea prevention and treatment of cancer by nutriceuticals. Lancet 2004 Sep 18;364(9439):1021-2.

8. Yamimoto T, Juneja LR, Djoing-Chu C, Kim M. Chemistry and Applications of Green Tea. Boca Raton, FL: CRC Press, 1997:51-52

9. Kawaii S, Tomono Y, et al. Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer Res. 1999 Mar-Apr;19(2A):1261-9.

10. Kotanidou, A. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am. J. Respir. Crit. Care Med. 2003 Mar 15; 165(6):818-23.

11. Kimata, M. Effects of luteolin and other flavenoids on IgE-mediated allergic reactions. Planta Med. 2000 Feb; 66(1): 25-9.

12. Surh, YJ, Chun, KS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: downregulation of Cox-2 and Inos through suppression of NFkappaB activation. Mut. Res. 480; 243-268. 2001.

13. Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002 May 15;364(Pt 1):301-7.

14. Faulkner K, Mithen R, et al. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli. Carcinogenesis. 1998 Apr;19(4):605-9.

15. Vang O, Frandsen H, et al. Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon. Metabolism. 2001 Oct;50(10):1123-9.

16. Vang O, Mortensen J, et al. Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. Metabolism. 2001 Oct;50(10):1130-5.

17. Smith, TK, Mithen, R, Johnson, IT. Effects of brassica vegetable juice on the induction of apoptosis of aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis 2003 Mar;24(3): 491-5.

18. Jackson, SJ, Singletary, KW Sulforaphane: a naturally occurring mammary carcinoma mitosis inhibitor, which disrupts tubulin polymerization. Carcinogenesis. 2004 Feb;25(2):219-27. Epub 2003 Oct 24 2004.

19. Nestle, M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149-11151.

20. Talalay, P, Fahey, JW. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. American Institute for Cancer Research 11th Annual Research Conference on Diet, Nutrition and Cancer, 2001 American Society for Nutritional Sciences: 3027S-3033S.

21. Fahey, J.W. et. al. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94: 10367-10372.

22. Hanausek, M, Walaszek, Z, Slaga, TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003 Jun;2(2): 139-44.

23. Walaszek, Z, Szemraj, J, Narag, M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and potential use in cancer prevention. Cancer Detect. Prev. 1997;21(2):178-90.

24. Walaszek Z, Hanausek M, et al. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Lett. 1990 Jan;49(1):51-7.

25. Riso, P, Brusamolino, A, Ciappellano, S, Porrini, M. Comparison of lutein biovailability from vegetables and supplement. Int. J. Vitam. Nutr. Res. 2003 May; 73(3):201-5.

26. Seddon, JM, Ajani, UA, Sperduto, RD et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413-20.

27. Wilcox, JK, Catignani, GL, Lazarus, S. Tomatoes and cardiovascular health. Crit. Rev. Food Sci. Nutr. 2003;43(1): 1-18.

28. Ahuja, KD, Ashton, EL, Ball, MJ Effects of lipid-lowering, carotenoid-controlled diets on the oxidative modifications of low-density lipoproteins in free-living humans. Clin. Sci. [Lond] 2003 Sep; 105(3): 355-61.

29. Wertz, K, Siler, U, Goralczyk, R. Lycopene: modes of action to promote prostate health. Arch. Biochem. Biophys. 2004 Oct 1;430(1):127-34.

30. Hannum SM. Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr. 2004;44(1):1-17.

31. Sauvaget C, Kasagi F, et al. Dietary factors and cancer mortality among atomic-bomb survivors. Mutat Res. 2004 Jul 13;551(1-2):145-52.

32. Maas, JL, Galletta, GJ, et al. Ellagic acid, an anticarcinogen in fruits, especially in strawberries: a review. HortScience. 1991;26(1): 10-14.

33. Visioli, F, Galli, C. Biological properties of olive oil phytochemicals. Cri. Rev. Food Sci. Nutr. 2002; 42(3):209-21.

34. Valavanidis, A, Nisiotou, C, Papageoriou, Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J. Agric. Food Chem. 2004 Apr 21;52[8:2358-65.

35. Ranalli, A, Lucera, L, Contento, S. Antioxidizing potency of phenol compounds in olive mill wastewater. J. Agric. Food Chem. 2003 Dec 17;51(26):7636-41.

36. Water-soluble Olive Polyphenols. Technical file, Inosud S.A. Groupe La Gardonnenque, updated 31/01/2003.

37. Valavanidis, A, Nisiotou, C, Papageoriou, Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J. Agric. Food Chem. 2004 Apr 21;52(8):2358-65.

38. Carluccio, MA, Siculella, L, Ancora, MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.

39. Paiva-Martins, F, Gordon, MH, Gameiro, P. Activity and location of olive oil phenolic antioxidants in liposomes. Chem Phys Lipids 2003 Jun; 124(1):23-36.

40. Haban, P, Klvanova, J, Zidekova, E, Nagyova, A. Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects. Med. Sci. Monit. 2004 Apr;10(4):PI49-54.

41. Vissers, MN, Zock, PL, Katan, MB. Bioavailability and antioxidant effects of olive oil phenols in humans – a review. Eur. J. Clin. Nutr. 2004 Jun;58(6): 955-65.

42. Parker, RS, Sontag, TJ. Cytochrome P-450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J. Biol. Chem. 2002 Jul 12;277(28):25290-6.

43. Meier, R, Tomizaki, T, Schulze-Briese, C, et al. The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol 2003 Aug 15;331(3:725-34.

44. Ikeda, S, Kagaya, M, Kobayashi, K, et al. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J. Nutr. Sci. Vitaminol [Tokyo]. 2003 Aug;49(4):270-6.

45. Kang, MH, Naito, M, Sakai, K, et al. Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro. Life Sci. 2000;66(2): 161-71.

46. Kang, MH, Naito, M, Tsujihara, N, Osawa, T. Sesamolin inhibits lipid peroxidation in rat liver and kidney. J. Nutr. 1998 Jun;128(6):1018-22.

47. Christen, S, Woodall, AA, Shigenaga, MK, et al. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) complements alpha-tocopherol: physiological implications. Proc. Natl. Acad. Sci. USA 1997 Apr;94(7):3217-22.

48. Crawford V, Scheckenbach R, Preuss HG. Effects of niacin-bound chromium supplementation on body composition of overweight African-American women. Diabetes Obes Metab.1999 Nov;1(6):331-7.

49. Grant KE, Chandler RM, Castle AL, Ivy JL. Chromium and Exercise Training: Effect on Obese Women. Med Science Sports Exer 1997;29: 992-8.

50. Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens. 1999 Aug;12(8 Pt 1):747-56.

51. Zhang H, Osada K, et al. A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. J Nutr Sci Vitaminol. (Japan) 1996; 42(6):517-26.

52. Koutsikos D., Fourtounas C., et al. Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Renal Failure (USA) , 1996;18(1):131-7.

53. Pacheco-Alvarez D, Solorzano-Vargas RS, et al. Biotin in metabolism and its relationship to human disease. Arch Med Res. 2002 Sep-Oct;33(5):439-47.

54. Koike M, Koshizuka K, et al. 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May-Jun;19(3A):1689-97.

55. Hisatake J, O’Kelly J, et al. Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood. 2001 Apr 15;97(8):2427-33.

56. Dietrich, T, Joshipura, KJ, Dawson-Hughes, B, Bischoff-Ferrari, H.A. Association between serum concentrations of 25-hydroxyvitamin D and periodontal disease in the U.S. population. Am. J. Clin. Nutr. 2004 Jul;80(1):108-13.

57. Doetsch, AM, Faber, J, Lynnerup, N, et al. The effect of calcium and vitamin D-3 supplementation on the healing of the proximal humerus fracture: a randomized placebo controlled study. Calcif Tissue Int. 2004 May 27. [Epub ahead of print]

58. Harwood RH, Sahota O, et al. A randomized controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham neck of femur study. Age Ageing 2004 Jan;33(1):45-51.

59. Dietrich T, Joshipura KJ, et al. Association between serum concentrations of 25-hydroxyvitamin D and periodontal disease in the U.S. population. Am J Clin Nutr. 2004 Jul;80(1):108-13.