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Life Extension Magazine

Top Ten Recommendations

1: Life Extension Mix

2: Life Extension Super Booster

3: Coenzyme Q10

4: Mitochondrial Energy Optimizer

5: Cognitex

6: Super EPA/DHA with Sesame Lignans

7: Enhanced Natural Prostate with Cernitin (Men)

7: Bone Restore (Women)

8: Restoring Youthful Hormone Balance

9: S-adenosyl-methionine (SAMe)

10: Aspirin

Recommendation: 5
Cognitex

DOSAGE: 3 capsules early in the day.

Many factors conspire to rob us of mental acuity as we age. But, scientists have discovered natural agents with the potential to slow or even reverse this once inevitable decline.

Since 1982, Life Extension has offered the multi-nutrient Cognitex formula to protect and enhance neurological function. Over the years, Cognitex has been improved in accordance with the latest research on the underlying causes of brain aging. Newly reformulated Cognitex now contains even more ingredients designed to provide broad spectrum protection against the multiple mechanisms involved in neurological deterioration.

The active ingredients in Cognitex attack the presumptive causes of age-related brain decline at the source. To inhibit the inflammation-inducing enzymes COX-2 and 5-LOX, Cognitex contains pharmaceutical extracts of Nexrutine® and 5-Loxin®.*1-9 Water-soluble quercetin helps improve cerebral blood flow.*10,11 Phosphatidylserine maintains neuronal membrane integrity and guards against cortisol toxicity.* Alpha-glycerylphosphorylcholine helps boost acetylcholine, a critical neurotransmitter that helps protect neuronal structure.*12-16 Vinpocetine enhances circulation and oxygenation to brain cells, improves neural electrical conductivity, and protects against neuron-destroying excitotoxicity.*17-19

Cognitex is available with or without pregnenolone, a hormone that may be especially beneficial to the brain. (Those with existing steroid hormone-sensitive cancers should not take pregnenolone.)20-22

Brain aging is a leading cause of death and disability in the elderly.23-24 The quest to slow brain aging is the reason many people contact the Life Extension Foundation. The antioxidants found in Life Extension Mix and Life Extension Booster protect against free radical damage to brain cells. The Cognitex formula provides nutrients that help maintain healthy cognitive function via additional mechanisms.

Previously, members had to swallow six Cognitex capsules per day, but a reformulation has reduced the number of capsules to only three. The following page lists the various ingredients included in the new formulation of Cognitex.

Just three softgel capsules of the new Cognitex contain pharmaceutical potencies of the following nutrients:

Glycerylphosphorylcholine (GPC)

600 mg

Nexrutine

500 mg

Quercetin (water-soluble)

125 mg

Phosphatidylserine (PS)

100 mg

5-Loxin®

50 mg

Pregnenolone

50 mg

Vinpocetine

15 mg

5-Loxin® is a registered trademark of Ph Thomas and Co., Inc.

There are 90 capsules in each bottle meaning that a bottle will last a healthy person one month.

More Info on Cognitex

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References

1. Sasaki T, Kitagawa K, et al. Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. J Cereb Blood Flow Metab. 2004 Jan;24(1):107-13.

2. Araki E, Forster C, et al. Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. Stroke. 2001 Oct;32(10):2370-5.

3. Hewett SJ, Uliasz TF, et al. Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther. 2000 May;293(2):417-25.

4. Bazan NG. The neuromessenger platelet-activating factor in plasticity and neurodegeneration. Prog Brain Res. 1998;118:281-91.

5. Iseki S. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem J. 1995 Apr;27(4):323-8.

6. Ammon HP, Safayhi H, et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.

7. Safayhi H, Mack T, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.

8. Dupuis P. Study of the effects of NPS0029 (Nextrutine™) on various human cyclooxygenase activities. Cerep Laboratories, France (unpublished).

9. Dennis and Company Research. Anti-inflammatory Dietary Supplement HUT: Open Human clinical trial evaluating the efficacy and safety of Nexrutine™. Sept 2000 (unpublished).

10. Knekt P, Isotupa S, et al. Quercetin intake and the incidence of cerebrovascular disease. Eur J Clin Nutr. 2000 May;54(5):415-7.

11. Conquer JA, Maiani G, et al. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr. 1998 Mar;128(3):593-7.

12. Parnetti L, Amenta F, et al. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mech Ageing Dev. 2001 Nov;122(16):2041-55.

13. Barbagallo Sangiorgi G, Barbagallo M, et al. alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann N Y Acad Sci. 1994 Jun 30;717:253-69.

14. Amenta F, Ferrante F, et al. Long term choline alfoscerate treatment counters age-dependent microanatomical changes in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep;18(5):915-24.

15. Parnetti L, Abate G, et al. Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer’s type. Drugs Aging. 1993 Mar-Apr;3(2):159-64.

16. Ricci A, Bronzetti E, et al. Oral choline alfoscerate counteracts age-dependent loss of mossy fibres in the rat hippocampus. Mech Ageing Dev. 1992;66(1):81-91.

17. McDaniel MA, Maier SF, et al. “Brain-specific” nutrients: a memory cure? Nutrition. 2003 Nov-Dec;19(11-12):957-75.

18. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol. 1987 Oct;2(4):325-31.

19. Subhan Z, Hindmarch I. Psychopharmacological effects of vinpocetine in normal healthy volunteers. Eur J Clin Pharmacol. 1985;28(5):567-71.

20. Mayo W, George O, et al. Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol. 2003 Sep;71(1):43-8.

21. Flood JF, Morley JE, et al. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10806-10.

22. Flood JF, Morley JE, et al. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1567-71.

23. J Neurosci Nurs. 2002 Aug;34(4):191-7.

24. Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):117-20.