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Life Extension Magazine

Top Ten Recommendations

1: Life Extension Mix

2: Life Extension Super Booster

3: Coenzyme Q10

4: Mitochondrial Energy Optimizer

5: Cognitex

6: Super EPA/DHA with Sesame Lignans

7: Enhanced Natural Prostate with Cernitin (Men)

7: Bone Restore (Women)

8: Restoring Youthful Hormone Balance

9: S-adenosyl-methionine (SAMe)

10: Aspirin

Recommendation: 8
Restoring Youthful Hormone Balance

Taking many vitamins will not make you feel better if you suffer from a hormone imbalance. Youthful hormone balance is critical to maintaining health in all women and men over age 40.

Aging men and women are invariably DHEA deficient.1-3 Many men over age 40 often have too much estrogen and too little free testosterone.4-6 Aging women need to balance their progesterone and estrogen (using safe natural estrogen supplements and drugs) levels. Thyroid deficiency is an epidemic problem, especially for women.7-8

The proper blood tests can provide the data needed to design an individualized hormone modulation program. Life Extension offers special blood test panels designed to help provide the information needed to safely achieve youthful hormone balance. The good news is prices of blood tests are much lower now than what they were a few years ago. This special issue of Life Extension magazine describes the most popular blood tests that members order.

The Most Popular Hormone Supplement
In 1981, the Life Extension Foundation introduced dehydroepiandrosterone (DHEA) to its members in an article describing this pro-hormone precursor’s multiple potential benefits.

DHEA did not become credible to the medical establishment until 1996, when the New York Academy of Sciences published a textbook entitled DHEA and Aging that provided scientific validation for many of DHEA’s effects. The public learned about DHEA later that same year, when its benefits were touted in the news media and in several best-selling books.

DHEA is the most abundant circulating hormone in the youthful human body. But research has shown that DHEA production peaks by age 25 and drops dramatically each year thereafter. By age 70 most people’s DHEA levels have declined by over 80%, leading to hormonal imbalances that can affect quality of life.9

Since 1981, thousands of studies have been published about DHEA. Considering DHEA’s potential benefits, many researchers advocate taking DHEA supplements to regain youthful circulating concentrations of this critical hormone.9 To achieve the DHEA levels of a 25-year-old, men normally take 50 mg a day, while women usually need only 15-25 mg a day.

Life Extension’s DHEA supplements contain 99.9% European-derived DHEA, manufactured under GMP (good manufacturing process) conditions and micronized for maximum absorption and utilization.

Note: DHEA is not for everyone. Those with existing prostate or breast cancer may wish to avoid taking it for now. For complete information, refer to the DHEA precautions.

A Natural Approach for Men
Sexual stimulation begins in the brain when testosterone binds to cell-receptor sites to ignite a cascade of pleasure-inducing biochemical events. Testosterone promotes sexual desire and then facilitates performance, sensation and the ultimate degree of fulfillment. Men with low testosterone routinely suffer from a decreased sex drive and impotence. Low testosterone has been linked to a host of age-related problems.

One reason aging males become testosterone deficient is the conversion of testosterone to estrogen. A natural method of boosting free testosterone levels is to block the aromatase enzyme that causes the conversion of testosterone to estrogen. A flavonoid called chrysin is a natural aromatase-inhibitor. In a study on twenty-two male subjects, 750 mg of chrysin and 10 mg of bioperine (a pepper extract that increases absorption of chrysin) was given twice daily for 30 days. When compared with baseline, the results showed 73% of the subjects demonstrated a statistically significant increase in free testosterone of 40%!10

Another reason why aging men are testosterone deficient is a blood component called sex hormone-binding globulin (SHBG) which binds to free testosterone, rendering it biologically inactive. Research has found that urtica dioica has a greater affinity for SHBG than testosterone.11 As a result, SHBG more readily binds to the constituents of the urtica dioica, successfully counteracting its effect, thus increasing the level of free testosterone.

A formula called Super MiraForte contains high concentrations of chrysin, bioperine, urtica dioica and muira puama. This formula is designed to help re-establish more youthful testosterone levels. A bottle containing 120 capsules retails for $56.00. If a Life Extension member buys four bottles during the Super Sale, the price is reduced to $34.20 per bottle. The suggested dose is two capsules, twice per day.

Caution: Men with prostate cancer should not take this product, nor should women.

A Natural Approach for Women
As women age, their natural production of hormones, such as estrogen and progesterone, declines. These hormonal deficits give rise to a host of unpleasant menopausal symptoms and accelerate various aging processes.

Estrogen does more than mitigate the unwanted effects of menopause. Researchers have found that estrogen confers a variety of benefits—helping to maintain firm skin and muscle tone, supporting healthy neurological, immune, and sexual function, and producing greater feelings of well being.*

For years, menopausal women relied on estrogen drugs to maintain youthful levels of this hormone. Yet concern about the potentially life-threatening side effects of hormone drugs has caused many women to deprive themselves of the benefits of hormone replacement therapy. One alternative to hormone drugs is phytoestrogens—natural estrogenic extracts from plant sources.

Natural Estrogen is a dietary supplement containing standardized plant extracts that may help relieve menopausal symptoms and produce hormone-modulating effects that are beneficial for most women over 40.12-31 Natural Estrogen contains health-promoting phytoestrogens from soy, as well as the following complementary plant extracts:

  • Licorice to facilitate estrogen synthesis32-34
  • Black cohosh to mimic the safe estrogen “estriol”35
  • Dong quai to modulate estrogen balance and progesterone synthesis36
  • Vitex agnus castus to establish hormone balance and suppress excess prolactin37-43

Suggested dose is one tablet, two times a day, which provides:

Phytoestrogens (isoflavones)

110 mg





Genistein and genistin

52 mg


Daidzein and daidzin

50 mg


Glycitein and glycitin

9 mg

Black cohosh extract, powdered

40 mg


2.5% triterpene



(Cimicifuga racemosa root and rhizome)


Don quai extract, powdered

25 mg


1% ligustilide



(Anglica sinesis root)


Licorice extract, powdered

25 mg


(Glycyrrhiza glabra root)


Vitex extract, powdered

20 mg


5% vitexicarpin



(Vitex agnus-castus fruit)


Aging women should also consider Natural Progesterone cream, along with melatonin supplementation each night. Information about these products can be found on the complete product listing found at the end of this month’s issue.

Caution: Those with an estrogen-dependent cancer should consult with their physician before using any type of estrogen supplement.

Comprehensive Hormone Replacement Options
To learn about comprehensive hormone modulation for aging men or women, refer to the Disease Prevention and Treatment book. Members can also discuss this with one of our life extension doctors by calling 1-800-226-2370.

Information about the Disease Prevention and Treatment book and a special holiday offer can be viewed here.

Men should refer to the following chapters in the Disease Prevention and Treatment book:

Women should refer to the following chapters in the Disease Prevention and Treatment book:

Based on the results of blood tests, some people will need natural hormone prescription drugs. Foundation members can discuss their hormone status with one of our staff physicians at no charge. To inquire about ordering blood tests, call 1-800-208-3444 or order online.

More Info on Restoring Youthful Hormone Balance

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1. Muller M, den Tonkelaar I, Thijssen JH, et al. Endogenous sex hormones in men aged 40-80 years. Eur J Endocrinol. 2003 Dec;149(6):583-9.

2. Burger HG, Dudley EC, Robertson DM, et al. Hormonal changes in the menopause transition. Recent Prog Horm Res. 2002;57:257-75.

3. Gonzales GF, Gonez C, Villena A. Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude. J Endocrinol. 2002 Apr;173(1):95-101.

4. Kley HK, Nieschlag E, Wiegelmann W, et al. Sexual hormones in ageing males. Aktuelle Gerontol 1976 Feb;6(2):61-7 (in German).

5. Drafta D, Schindler AE, Stroe E, et al. Age-related changes of plasma steroids in normal adult males. J Steroid Biochem 1982 Dec;17(6):683-7

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37. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003 Apr;18(3):191-5.

38. Halaska M, Beles P, Gorkow C, et al. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast. 1999 Aug;8(4):175-181.

39. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytophar- maceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med. 2000 Apr;9(3):315-20.

40. Wuttke W, Jarry H, Christoffel V, et al. Chast tree (Vitex agnus-castus) – pharmacology and clinical indications. Phytomedicine. 2003 May;10(4):348-57.

41. Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)—pharmacology and clinical indications. Phytomedicine. 2003 May;10(4):348-57.

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