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Life Extension Magazine

Top Ten Recommendations

1: Life Extension Mix

2: Life Extension Super Booster

3: Coenzyme Q10

4: Mitochondrial Energy Optimizer

5: Cognitex

6: Super EPA/DHA with Sesame Lignans

7: Enhanced Natural Prostate with Cernitin (Men)

7: Bone Restore (Women)

8: Restoring Youthful Hormone Balance

9: S-adenosyl-methionine (SAMe)

10: Aspirin

Recommendation: 9
S-adenosylmethionine (SAMe)

DOSAGE: 200 mg to 1600 mg per day.

The unique biological properties of SAMe makes it a critical component of a health maintenance program. SAMe is the most effective facilitator of youthful methylation. Published research shows that methylation defects create a variety of agerelated disorders including neuronal and hepatic dysfunction.1-8 Enhancing youthful methylation facilitates healthy enzymatic life processes throughout the body.

Not only can SAMe enhance mood and alleviate melancholy, but it can also protect the joint linings from structural degradation.9-13 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.

An agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe in 2002. Their findings show that the efficacy of SAMe is comparable to mainstream medicine in promoting good mood and bone and joint health. The difference, however, is that SAMe is virtually free of the side effects.14

This U.S. government report concluded that SAMe is 80% better in promoting joint comfort. This report also verified that SAMe was as effective as nonsteroidal anti-inflammatory drugs (NSAIDs) in treating bone and joint discomfort. The significance of this finding is that NSAIDs are associated with serious side effects, whereas SAMe provides benefits throughout the body.14

SAMe should be taken with cofactors vitamin B12 and folic acid.15 If you take the Life Extension Mix and/or the Life Extension Booster, you will get these cofactors.

Not all SAMe supplements are created equal. SAMe is an unstable molecule that requires special processing to ensure stability. Analysis of several popular brands of SAMe revealed many of them did not contain what was claimed on the label. (Refer to page 91 for an update about quality control problems with commercial SAMe supplements).

More Info on S-adenosylmethionine (SAMe)

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1. Paulsen M, Ferguson-Smith AC. DNA methylation in genomic imprinting, development, and disease. J Pathol. 2001 Sep;195(1):97-110.

2. Zhu BT. Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis. Curr Drug Metab. 2002 Jun;3(3):321-49.

3. Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49.

4. Anzola M, Cuevas N, Lopez-Martinez M, et al. Patterns of methylation profiles as diagnostic markers for multiple hepatocellular carcinomas. Scand J Gastroenterol. 2004 Mar;39(3):246-51.

5. Poschl G, Stickel F, Wang XD, et al. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71.

6. Wainfan E, Poirier LA. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res. 1992 Apr 1;52(7 Suppl):2071s-2077s.

7. Bell KM, Potkin SG, Carreon D, et al. S-adenosylmethionine blood levels in major depression: changes with drug treatment. Acta Neurol Scand Suppl. 1994;154:15-8.

8. Becker A, Smulders YM, Teerlink T, et al. S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations. Eur J Clin Invest. 2003 Jan;33(1):17-25.

9. Kagan BL, Sultzer DL, Rosenlicht N, et al. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5.

10.Bell KM, Plon L, Bunney WE Jr, Potkin SG. S-adenosylmethionine treatment of depression: a controlled clinical trial. Am J Psychiatry. 1988 Sep;145(9):1110-4.

11. Glorioso S, Todesco S, Mazzi A, et al. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharmacol Res. 1985;5(1):39-49.

12.Najm WI, Reinsch S, Hoehler F, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a doubleblind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5(1):6.

13. Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside‚ÄĒmolecular basis of a pleiotrophic molecule. Am J Clin Nutr. 2002 Nov;76(5):1151S-7S.

14.Evidence Report/Technology Assessment No. 64, S-Adenosyl-LMethionine for Treatment of Depression, Osteoarthritis, and Liver Disease. http://www.ahrq.gov/clinic/epcsums/samesum.htm#Contents15.

15. Miller AL. The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev. 2003 Feb;8(1):7-19.