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Life Extension Magazine

LE Magazine March 2004
Increasing Fiber Intake May Slow Atherosclerosis

New research supports the hypothesis that fiber retards the progression of cardiovascular disease through its effect on lipids. Published in the American Journal of Clinical Nutrition, the findings were obtained from the Los Angeles Atherosclerosis Study, a prospective study that is investigating fiber’s ability to help combat atherosclerosis.*

In the study, 500 men and women between the ages of 40 and 60 with no history of cardiovascular events received baseline examinations and were followed for three years. Dietary information was obtained through oral and telephone interviews at the beginning of the study and at the first follow up at 18 months. Intima-media thickness of the common carotid arteries (a measure of atherosclerosis) was determined by ultrasound examination at the study’s onset, at 18 months, and at three years. Blood samples taken at all three examinations provided data on serum lipids.

The median total fiber intake in the fifth of the study population with the highest fiber intake was found to be twice that of the fifth with the lowest fiber intake. Intima-media thickness progression declined with an increase in fiber intake. The trend was significant for viscous (soluble) fiber found particularly in fruits and vegetables, and in pectin. Controlling for the intake of fruit and vegetables, which have other anti-atherogenic constituents, did not alter the findings.

Increased high-density lipoprotein (HDL) levels were correlated with an increase in total fiber, viscous fiber, and pectin. Additionally, the ratio of total cholesterol to HDL improved with greater total fiber, viscous fiber, and pectin intake. The study authors concluded: “The present study suggests that increased dietary fiber intake has significant cardiovascular benefit and that the regulation of serum lipids by dietary fiber may be partially involved in the process of slowing the progression of atherosclerosis.”

—Dayna Dye

Reference

* Wu H, Dwyer KM, Fan Z, Shircore A, Fan J, Dwyer JH. Dietary fiber and progression of atherosclero- sis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr. 2003 Dec;78(6):1085-91.

Potassium Supplementation Reduces Blood Pressure

Previous research has associated low potassium intake with higher rates of hypertension and related complications. In a study recently published in the British Journal of Nutrition, researchers at King’s College London found that a daily supplement of potassium is effective in reducing blood pressure.*

The double-blind, placebo-controlled trial enrolled 59 volunteers who were randomly assigned to receive either 24 mmol/day (approximately 1.8 grams) of a slow-release potassium chloride supplement or placebo. Six weeks later, mean arterial pressure was reduced in the potassium-supplemented group by 7.01 mmHg, systolic blood pressure was lowered by 7.60 mmHg, and diastolic blood pressure dropped by 6.46 mmHg. The researchers concluded that a daily dietary supplement of potassium, equivalent to the content of five portions of fresh fruits and vegetables, induces a substantial reduction in mean arterial pressure, similar in effect to single-drug therapy for hypertension.

Editor’s Note: Anyone taking this much potassium should have their doctor monitor blood potassium levels.

—Carmia Borek, PhD

Reference

* Naismith DJ, Braschi A. The effect of low- dose potassium supplementation on blood pressure in apparently healthy volunteers. Br J Nutr. 2003 Jul;90(1):53-60.

B Vitamins Lower Dangerous Homocysteine Levels

Elderly people are more likely to have B-vitamin deficiencies than younger people. While diet plays an important role, the elderly’s greater use of prescription drugs and lower vitamin bioavailability also contribute to these deficiencies. In addition, the activity of enzymes involved in vitamin metabolism declines 25% between the ages of 18 and 90. Because homocysteine is a risk factor for coronary artery disease—and one that increases with advancing age—scientists are exploring how B vitamins may influence homocysteine levels.

Researchers at Germany’s University of Hanover evaluated the dietary intake and blood status of 178 German women aged 60 to 70 years old.* The study participants completed a three-day diet record that assessed their energy and nutrient intakes. This was compared to the corresponding recommended dietary allowance (RDA) for older women. Blood samples were drawn after an overnight fast and used to measure the levels of thiamine (B1), riboflavin (B2), pyridoxine (B6), cobalamin (B12), folate, and homocysteine.

Riboflavin intake was sufficient for the most part, with only 2% of the study participants below the RDA. By contrast, more than 82% of the women had a folate intake below the RDA. Blood levels of cobalamin, thiamine, and pyridoxine were below the respective RDAs for these vitamins in 42%, 29%, and 17% of the women, respectively. Plasma homocysteine was dramatically elevated in 17% of the study participants. Because the subjects had above-average levels of education, the researchers speculated that poor B-vitamin status might be even more prevalent in the general population.

This study found significantly higher homocysteine levels when both folate and cobalamin were low. Supplementation with B vitamins is therefore advisable, as is a follow-up test of homocysteine levels to ensure that your vitamin intake is appropriate.

Reference

* Wolters M, Hermann S, Hahn A. B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women. Am J Clin Nutr. 2003 Oct;78(4):765- 72.

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