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Life Extension Magazine

LE Magazine Special Edition, Winter 2005/2006

NEW LIFE EXTENSION MIX
with Standardized Blueberry Extract

Public service campaigns are encouraging people to eat more fruits and vegetables to maintain a healthy lifestyle. Despite years of media publicity, 85% of Americans are not even eating the minimum recommendation of five servings of fruits and vegetables per day. Those who do report eating some produce often fail to consume the yellow and purple colored plants that are critical components of such a program.

Life Extension Mix™ contains 93 unique vegetable, fruit, and herbal extracts along with high-potency amino acids, vitamins, minerals, and special antioxidants. The Life Extension Mix formula is fortified with botanical extracts that help maintain healthy cells via physiological processes separate from traditional antioxidants. Consumption of these types of plants is being recommended based on research emanating from the world’s most prestigious medical centers.

The newest ingredients in the Life Extension Mix formula are two standardized blueberry extracts that provide the most active constituents found in this health-promoting fruit.

Blueberry anthocyanins are considered nature’s most potent antioxidants and have demonstrated properties that extend well beyond suppressing free radicals.

Pterostilbene, another blueberry constituent, helps maintain healthy lipid and glucose levels.* Even more exciting is that through their unique biological effects; pterostilbene and anthocyanins may help support DNA structure.*

The new Life Extension Mix provides blueberry extracts standardized with both anthocyanins and pterostilbene.

Standardized Green Tea Extract

The Life Extension Foundation introduced green tea extract as a supplement in 1993, based on epidemiological studies showing that those who consumed green tea had much lower incidences of common health problems. Over the past 12 years, an enormous amount of positive studies about the health benefits of green tea have been published.

Scientists have looked at the active “polyphenol” constituents of green tea and have found that they possess remarkable biological activity at the cellular level. Researchers have also identified multiple mechanisms by which green tea extract helps maintain healthy DNA, protect against LDL oxidation, neuronal peroxidation, and a host of other adverse structural and functional age-related changes.*1-7

The new Life Extension Mix provides 325 mg of a decaffeinated green tea extract that is standardized to contain 302 mg of the polyphenols that scientists have attribute to green tea’s health benefits.

The amount of polyphenols (including EGCG) in Life Extension Mix is equivalent to drinking about 3-6 cups of green tea per day.

Vegetable Extracts

Luteolin is a flavonoid found in parsley, artichoke, basil, celery, and other foods. When measured against 27 other flavonoids, luteolin had the best DNA protection.

One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin’s ability to suppress excess levels of dangerous inflammatory cytokines such as interleukin-6 and interleukin 1b.8 Life Extension Mix contains a standardized dose of 8 mg of luteolin.

Broccoli is touted as one of the most important vegetables to help maintain healthy DNA. Broccoli contains several active constituents, with sulphoraphane being the most significant because of its unique detoxification and DNA protecting effects. The new Life Extension Mix provides a concentrated broccoli mixture that provides standardized extracts of sulphoraphane and gluco-sinolates, two compounds attributed to broccoli’s multiple protective benefits. Broccoli is also a natural source of gene protecting chlorophyll.*9-13

D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli, and brussels sprouts.

D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body.14,15 The daily dose of Life Extension Mix provides 200 mg of D-glucarate.

Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula, while the carotenoid alpha carotene has demonstrated antioxidant activity far greater than beta-carotene. Lycopene from tomatoes has shown potent effects in helping to maintain healthy DNA structure and protect against LDL oxidation. Life Extension Mix™ contains 60 times more lutein and 10 times more lycopene compared to Centrum®. Most multivitamin supplements provide no vegetable extracts whatsoever.

Fruit Extracts

Life Extension Mix is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to provide healthy circulation throughout the body and maintain healthy DNA.*

Ellagic acid is a detoxifying agent found in raspberries, strawberries, and other fruit. Ellagic acid has demonstrated DNA-protecting properties, including the ability to bind to toxins and neutralize them. Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. Life Extension Mix contains a raspberry and pomegranate fruit extract to deliver 50 mg of ellagic acid in each daily dose.

The media has publicized the multiple benefits of fruits such as blackberry, cranberry, elderberry, cherry, plums, and persimmon. Life Extension Mix has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body.

Olive oil consumption is one of the important factors behind the health benefits of the “Mediterranean Diet.”16,17 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.18,19 Olive polyphenols have been the subject of numerous studies pointing toward their benefits in many different areas, including helping to protect against LDL oxidation, suppressing free radicals, and stabilizing cell membranes.20-22 Life Extension Mix contains a potent olive juice extract standardized to contain 7% of the best-documented polyphenol called hydroxytyrosol.23

Sesame Lignans Enhance the Effects of Vitamin E

Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.26,27

Sesame lignans increase the anti-inflammatory index of fish oils and help maintain healthy cholest- erol/LDL levels in humans.*28-31

Life Extension Mix contains 10 mg of sesame lignan extract to provide the direct benefits of the lignans and augment the effects of vitamin E and other nutrients in the body such as gamma tocopherol and gamma linolenic acid (GLA).

Maintaining Healthy Blood Glucose Levels

Chromium, along with magnesium and biotin, are nutrients required to maintain optimal blood sugar levels. Life Extension Mix provides 500 mcg of chromium, a better absorbable form of magnesium, and a super high potency of biotin. A review of studies showing benefits of chromium supplementation reveals that doses exceeding 200 mcg a day is required for optimal effects.32,33

High Potency Vitamin D3

Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to inflict toxicity on a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density. In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix provides 800 IU of vitamin D3 per daily dose.

The Most Complete Multi-Nutrient Formula

Life Extension Mix saves time and money by combining the most popular nutrient supplements into one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements, and much more that would be required to achieve the same effects.

Life Extension Mix supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Other ingredients in Life Extension Mix enhance beneficial DNA methylation patterns, help maintain glycemic control, and healthy levels of LDL.*

Life Extension Mix is the cornerstone of a comprehensive supplement program because it provides so many well-studied nutrients. If you are on a budget, the Life Extension Mix provides the best “cost-per-milligram” value.

With the addition of two standardized blueberry extracts, the Life Extension Mix has become an even greater value.

Life Extension mandates that the ingredients in the Life Extension Mix come only from quality suppliers. These premium companies charge more for their vitamins and trace elements, but the purity of these substances greatly exceeds that of the lower cost versions that are so prevalent in the vitamin industry. Turn to the next page for a complete description of the new Life Extension Mix™ formula.

References

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2. Yang CS, Chung JY, Li C et al. Mechanisms of inhibition of carcinogenesis by tea. Biofactors 2000;13:(1-4):73-9.

3. Fujiki H. Two stages of cancer prevention with green tea. J. Cancer Res. Clin Oncol 1999 Nov;125(11):589-97.

4. Xu JZ, Yeung SY, Chang Q et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr. 2004 Jun;91(6):873-81.

5. Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechins in humans. Biofactors 2000;13(1-4):55-9.

6. Xie D, Liu G, Zhu G et al. [-]-Epigallocatechin-3-gallate protects cultured spiral ganglion cells from H202-induced oxidizing damage. Acta Otolaryngol. 2004 May;124(4): 464-70.

7. Beliveau R, Gingras D. Green tea prevention and treatment of cancer by nutriceuticals. Lancet 2004 Sep 18;364(9439):1021-2.

8. Kotanidou A. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med. 2003 Mar 15; 165(6):818-23.

9. Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002 May 15;364(Pt 1):301-7.

10. Faulkner K, Mithen R, et al. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli. Carcinogenesis. 1998 Apr;19 (4):605-9.

11. Vang O, Frandsen H, et al. Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon. Metabolism. 2001 Oct;50 (10):1123-9.

12. Vang O, Mortensen J, et al. Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. Metabolism. 2001 Oct;50(10):1130-5.

13. Smith, TK, Mithen, R, Johnson, IT. Effects of brassica vegetable juice on the induction of apoptosis of aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcino genesis 2003 Mar: 24(3):491-5.

14. Hanausek, M, Walaszek, Z, Slaga, TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003 Jun;2(2): 139-44.

15. Walaszek, Z, Szemraj, J, Narag, M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and potential use in cancer prevention. Cancer Detect Prev. 1997;21(2):178-90.

16. Visioli, F, Galli, C. Biological properties of olive oil phytochemicals. Cri Rev Food Sci Nutr. 2002; 42(3):209-21.

17. Valavanidis, A, Nisiotou, C, Papageoriou, Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

18. Ranalli A, Lucera L, Contento S. Antioxidizing potency of phenol compounds in olive mill wastewater. J Agric Food Chem. 2003 Dec 17;51(26):7636-41.

19. Water-soluble Olive Polyphenols. Technical file, Inosud S.A. Groupe La Gardonnenque, updated 31/01/2003.

20. Valavanidis A, Nisiotou C, Papageoriou Y et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

21. Carluccio MA, Siculella L, Ancora MA et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.

22. Paiva-Martins F, Gordon MH, Gameiro P. Activity and location of olive oil phenolic antioxidants in liposomes. Chem Phys Lipids 2003 Jun; 124(1):23-36.

23. Visioli, F, Galli, C. Biological properties of olive oil phytochemicals. Cri Rev Food Sci Nutr. 2002; 42(3):209-21.

24. Haban P, Klvanova J, Zidekova E et al. Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects. Med Sci Monit. 2004 Apr;10(4):PI49-54.

25. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans – a review. Eur J Clin Nutr. 2004 Jun;58(6):955-65.

26. Parker RS, Sontag TJ. Cytochrome P-450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem. 2002 Jul 12;277(28):25290-6.

27. Meier R, Tomizaki T, Schulze-Briese C et al. The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol 2003 Aug 15;331(3:725-34.

28. Ikeda S, Kagaya M, Kobayashi K et al. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nutr Sci. Vitaminol [Tokyo). 2003 Aug;49(4):270-6.

29. Kang MH, Naito M, Sakai K et al. Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro. Life Sci. 2000;66(2): 161-71.

30. Kang MH, Naito M, Tsujihara N et al. Sesamolin inhibits lipid peroxidation in rat liver and kidney. J Nutr. 1998 Jun;128(6):1018-22.

31. Christen S, Woodall AA, Shigenaga MK et al. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci. USA 1997 Apr;94(7): 3217-22.

32. Crawford V, Scheckenbach R, Preuss HG. Effects of niacin-bound chromium supplementation on body composition of overweight African-American women. Diabetes Obes Metab. 1999 Nov;1(6):331-7.

33. Grant KE, Chandler RM, Castle AL et al. Chromium and exercise training: Effect on obese women. Med Science Sports Exer. 1997;29: 992-8.