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Life Extension Magazine

LE Magazine January 2005
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American Medical Association Discovers Gamma Tocopherol

How Much Is Your Life Worth?

If you wanted to learn about the lifesaving benefits of gamma tocopherol back in 1998, you needed to be a member of the Life Extension Foundation. No one else offered the benefits of gamma tocopherol back then.

Dedicated supplement users have been consuming lots of alpha tocopherol and thinking they were protecting themselves against destructive free radicals. The Life Extension Foundation, on the other hand, long ago warned that those who take regular vitamin E supplements should also take gamma tocopherol, since alpha tocopherol can displace gamma tocopherol in the body.8 The most prestigious scientific journals in the world now agree with what Life Extension advocated more than six years ago.

Each month, members read about new ways of staving off aging and death in Life Extension magazine.

It costs $75 a year to be a member of the Life Extension Foundation. Some people think that is a lot of money, but if the only benefit of membership were finding out about the critical importance of gamma tocopherol, this alone would have been well worth the membership fee.

The good news for price-conscious consumers is that gamma tocopherol with sesame lignans costs a lot less than gamma tocopherol-tocotrienols and has been shown to better fend off toxic oxidative and inflammatory reactions in the body.

Why to Stock Up on Nutrients Now

As long-time members know, now is the time to obtain extra-special discounts on all of the advanced formulations offered by the Life Extension Buyers Club. Every time you purchase a supplement that might add years of healthy life, you help support the world’s most ambitious scientific research program to abolish the scourge of age-related disease.

I want to personally thank our 100,000+ members who have so generously supported our scientific efforts. The Life Extension Foundation funded a record-breaking amount of research in 2004, and has been awarded a $900,000 grant from the National Institutes of Health to further our pioneering scientific endeavors.

For longer life,
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William Faloon

References

1. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004 Feb 4;291(5):565-75.

2. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002 Nov 27;288(20):2569-78.

3. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer’s disease. JAMA. 2002 Jun 26;287(24):3223-9.

4. Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002 Jun 19;287(23):3127-9.

5. Fairfield KM, Flectcher RH. Vitamins for chronic disease prevention in adults: scientific review. JAMA. 2002 Jun 19;287(23):3116-26.

6. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA. 1997 Oct. 22-29;278(16):1327-32.

7. Rapola JM, Virtamo J, Haukka JK, et al. Effect of vitamin E and beta-carotene on the incidence of angina pectoris. A randomized, double-blind, controlled trial. JAMA. 1996 Mar 6;275(9):693-8.

8. Available at: http://www.lef.org/magazine/mag98/feb98_newproduct.html. Accessed October 12, 2004.

9. Friedrich MJ. To “E” or not to “E,” vitamin E’s role in health and disease is the question. JAMA. 2004 Aug 11;292(6):671-3.

10. Faloon W. What the news media did not reveal about Bill Clinton’s heart problem. Life Extension. November 2004:9-16.

11. Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha-tocopherol, gamma tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23.

12. Stone WL, Papas AM, LeClair IO, Qui M, Ponder T. The influence of dietary iron and tocopherols on oxidative stress and ras-p21 levels in the colon. Cancer Detect Prev. 2002;26(1):78-84.

13. Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K. Gamma (gamma) tocopherol upregulates peroxisome proliferators activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. BMC Cancer. 2003 Oct 1;3(1):25.

14. Bae MA, Rhee H, Song BJ. Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines. Toxicol Lett. 2003 Mar 20;139(1):67-75.

15. Galli F, Stabile AM, Betti M, et al. The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Arch Biochem Biophys. 2004 Mar 1;423(1):97-102.

16. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol—an underestimated vitamin. Ann Nutr Metab. 2004;48(3):169-88.

17. Hensley K, Benaksas EJ, Bolli R, et al. New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med. 2004 Jan 1;36(1):1-15.

18. Kang M, Katsuzaki H, Osawa T. Inhibition of 2,2’-azobis[2,4-dimethylvaleronitrile]- induced lipid peroxidation by sesaminols. Lipids. 1998 Oct;33(10):1031-6.

19. Yamashita K, Lizuka Y, Imai T, Namiki M. Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low a-tocopherol diet. Lipids. 1995 Nov;30(11):1019-28.

20. Yamashita K, Nohara Y, Katayama K, Namiki M. Sesame seed lignans and gamma-tocopherol act synergistically to produce vitamin E activity in rats. Nutr. 1992 Dec;122(12):2440-6.

21. Ikeda S, Tohyama T, Yamashita K. Dietary sesame seed and its lignans inhibit 2,7,8- trimethyl-2[2’-carboxyethyl]-6-hydrochroman excretion into urine of rats fed gamma-tocopherol. J Nutr. 2002 May;132(5):961-6.