At a recent scientific conference in Italy, independent researchers with no financial ties to Life Extension presented important new findings showing that Life Extension’s phytoestrogen formula provides significant neuroprotection.1
The Italian researchers tested Life Extension’s Natural Estrogen supplement to determine whether its phytoestrogen ingredients protect the central nervous system from toxic degeneration. The study focused on specific cells in the central nervous system that fuel neurodegenerative diseases by releasing large amounts of inflammatory cytokines. Phytoestrogens, which are plant-derived compounds found in nutrients like soy and licorice root, help cells of the central nervous system fight dangerous inflammation.
This study was performed on rats so that the supplement’s specific effects could be documented by removing the animals’ ovaries and performing a surgical biopsy of cells from their nervous systems, neither of which would be possible in a human clinical study of this type.
Adult female rats received standard food and orally administered Natural Estrogen. A similar group of animals that received standard food but no phytoestrogen formula served as a control group. The scientists then surgically removed cells from the central nervous systems of the test animals. The cells were exposed to an inflammation-provoking toxin, and levels of inflammatory and protective cytokines were measured over the course of 24 hours.
Exposure to the toxin increased levels of all the measured cytokines. Compared to cells in the control animals, cells of the supplemented rats had significantly lower levels of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin beta, and interleukin-6, and higher levels of a neuroprotective compound known as transforming growth factor beta.
These exciting findings suggest that the phytoestrogen formulation used by many Life Extension members safely and effectively optimizes the health of the brain and nervous system by decreasing production of deadly inflammatory cytokines.
Editor’s Note: This experiment utilized Life Extension’s Natural Estrogen formula. Life Extension also offers a Natural Estrogen with Pomegranate Extract formula, which supplies the additional benefits of pomegranate extract, broccoli extract, and HMRlignan™.
—Elizabeth Wagner, ND