Fall Skin Care Sale

Life Extension Magazine

LE Magazine Super Sale 2006
image

New... Life Extension Mix

Now with standardized Pomegranate Extract and more potent Green Tea Extract (Tablets, Capsules, or Powder)

Health organizations like the American Cancer Society and American Heart Association continue to urge people to eat more fruits and vegetables. Despite years of heavy media publicity, however, the vast majority of Americans do not come close to eating the recommended five servings of fruits and vegetables each day.

People who do report eating some fruit or vegetables often fail to consume the yellow and purple colored plants that are critical components of a disease prevention program. Yet, scientists are increasingly telling Americans that they must consume these kinds of plants in order to avoid a myriad of age-related problems.

Life Extension Mix is formulated to provide 26 concentrated fruit and vegetable extracts along with high-potency amino acids, vitamins, minerals, and special antioxidants. The Life Extension Mix formula is fortified with botanical extracts that maintain healthy DNA structure via physiological processes separate from traditional antioxidants.

Standardized Pomegranate Extract

The newest ingredient added to Life Extension Mix is a pomegranate powdered extract that provides the full spectrum of polyphenols found in whole pomegranate fruit. This whole fruit extract has been standardized to provide the biologically active punicalagins that are so unique to pomegranate.

Pomegranate punicalagins are 100% water soluble and have shown a remarkable 95% absorption rate.1 When tested against popular antioxidant food extracts, pomegranate demonstrated the most potent free radical-suppressing effects. This means that pomegranate punicalagins not only absorb much better than other natural antioxidants, but they also have a superior antioxidant capacity.

Based on peer-reviewed published human studies showing that pomegranate helps maintain healthy cardiovascular and prostate function,2-8* this new standardized pomegranate extract has been added to all versions of Life Extension Mix.

The daily dose of Life Extension Mix now provides the equivalent of consuming up to 2.6 ounces of pomegranate juice—without the sugar calories—and at no additional cost.

Standardized Blueberry Extracts

Blueberry anthocyanins are potent natural antioxidants that have demonstrated properties that extend well beyond suppressing free radicals.

For instance, blueberries have been shown to not only improve memory, but to also undo some of the degenerative changes seen in aging neurons. One study showed that the ability of blueberries to suppress free radical and inflammatory damage in the brain was analogous to long-term calorie restriction.9,10 These findings hint that blueberries might be able to reverse certain aspects of brain aging!

Pterostilbene, the other blueberry constituent, helps maintain already normal lipid and glucose levels.11,12 Even more exciting is that these blueberry constituents (pterostilbene and anthocyanins) may help protect DNA structure.13

The Life Extension Mix formula continues to provide the standardized blueberry extracts that provide the most active constituents found in this heath-promoting fruit.

A More Potent Green Tea Extract

The Life Extension Foundation introduced green tea extract as a supplement in 1993 based on epidemiological studies showing that people who consumed green tea had lower incidences of common degenerative problems.14 Over the past 13 years, an enormous volume of positive studies has been published about the health benefits of green tea.

Scientists have looked at the active “polyphenol” constituents of green tea and have found that they possess remarkable biological activities that include inhibiting LDL oxidation and neuronal peroxidation, while maintaining healthy DNA structure.15-21

The new Life Extension Mix contains 325 mg of a decaffeinated green tea extract that is standardized to provide 98% of the active polyphenols that scientists attribute to green tea’s multiple health benefits.

The amount of polyphenols (including EGCG) in Life Extension Mix is equivalent to drinking about 3-4 cups of green tea per day.

Standardized Vegetable Extracts

Luteolin is a flavonoid found in parsley, artichoke, basil, celery, and other foods. When measured against 27 other flavonoids, luteolin provided the most DNA protection.22

One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin’s ability to suppress excess levels of dangerous inflammatory cytokines such as interleukin-6 and interleukin Ib.23,24

Life Extension Mix contains a standardized dose of 8 mg luteolin, a dose that emulates the benefits seen in published scientific studies.

Broccoli is touted as one of the most important vegetables to maintain healthy DNA gene structure. Broccoli contains several active constituents, with sulforaphane being the most significant because of its unique detoxification and DNA protecting effects. Life Extension Mix provides a concentrated broccoli mixture that provides standardized extracts of sulforaphane and glucosinolates, two compounds attributed to broccoli’s multiple protective benefits. Broccoli is also a natural source of gene-protecting chlorophyll.25-32

D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli, and Brussels sprouts. D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body. The daily dose of Life Extension Mix provides 200 mg of D-glucarate.33-35

Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula.36 The carotenoid alpha carotene has demonstrated antioxidant activity greater than beta-carotene, whereas lycopene from tomatoes has shown potent effects in helping to maintain DNA structure and protecting against LDL oxidation.37-39 Life Extension Mix contains 60 times more lutein and 10 times more lycopene compared to Centrum®. Most multivitamin supplements provide no vegetable extracts whatsoever.

Standardized Fruit Extracts

In addition to standardized pomegranate and blueberry extracts, Life Extension Mix is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to provide healthy circulation throughout the body and maintain healthy DNA.

The media has touted the multiple benefits of fruits such as blueberry, blackberry, cranberry, plums, elderberry, persimmon, and cherry. The new Life Extension Mix has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body.

Olive oil consumption is one of the important factors behind the health benefits of the “Mediterranean Diet.”40,41 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.42 Olive polyphenols have been the subject of numerous in vitro, in vivo, and human studies pointing toward their benefits in many different areas, including protecting against LDL oxidation, suppressing free radicals, and stabilizing cell membranes.43-45 Life Extension Mix contains a potent olive extract standardized to provide the best-documented polyphenol, hydroxytyrosol.47

Sesame Lignans Enhance The Effects of Vitamin E

Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.48,49

Sesame lignans increase the anti-inflammatory index of fish oils, decrease LDL oxidation, and help maintain already normal cholesterol/LDL levels in humans.50-53 Life Extension Mix provides 10 mg of a sesame lignan extract to supply the direct benefits of the lignans, and augment the effects of vitamin E and other nutrients in the body such as gamma tocopherol and gamma linolenic acid (GLA).

Maintaining Healthy Blood Glucose Levels

Chromium, along with magnesium and biotin, are nutrients required to maintain already normal blood sugar levels. Life Extension Mix provides 500 mcg of chromium, a better absorbable form of magnesium, and a super high potency biotin. A review of studies showing benefits of chromium supplementation reveals that doses exceeding 200 mcg a day is required for optimal effects.54-58

High Potency Vitamin D3

Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to inflict toxicity on a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density and maintaining healthy cell division.59-63 In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix provides 800 IU of vitamin D3 per daily dose.

The Most Complete Multi-Nutrient Formula

Life Extension Mix saves time and money by combining the most popular nutrient supplements into one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements, and much more that would be required to achieve the same effects.

Life Extension Mix supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Other ingredients in Life Extension Mix enhance beneficial DNA methylation patterns, help maintain glycemic control, and help prevent the oxidation of LDL that contributes to the buildup of deposits in the endothelial lining.

Life Extension Mix is the cornerstone of a comprehensive supplement program because it provides so many well-studied nutrients. If you are on a budget, the Life Extension Mix provides the best “cost-per-milligram” value.

With the addition of standardized pomegranate extract, Life Extension Mix is now an even greater value.

References

1. Cerda B, Llorach R, Ceron JJ, et al. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 2003 Jan;42(1):18-28 [First report on absorption of punicalagin].

2. Aviram M, Dornfeld L, Kaplan M, et al. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res. 2002 28(2-3):49-62.

3. Kaplan M, Hayek T, Raz A, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001 Aug;131(8):2082-9.

4. Huang TH, Peng G, Kota BP, et al. Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids. Br J Pharmacol. 2005 Jul;145(6):767-74.

5. Fuhrman B, Volkova N, Aviram M. Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. J Nutr Biochem. 2005 Sep;16(9):570-6.

6. Pantuck AJ, Leppert JT, Zomorodian N, et al. Cancer Therapy: Clinical Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer. Clin Cancer Res. 2006 Jul 1;12(13):4018-26.

7. Malik A, Mukhtar H. Prostate cancer prevention through pomegranate fruit. Cell Cycle. 2006 Feb;5(4):371-3.

8. Malik A, Afaq F, Sarfaraz S, et al. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8.

9. Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging. 2006 Feb;27(2):344-50.

10. Joseph JA, Shukitt-Hale B, Denisova NA, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation J Neurosci. 1999 Sep 15;19(18):8114-21.

11. Rimando AM, Nagmani R, Feller DR, et al. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem. 2005 May 4;53(9):3403-7.

12. Rimando AM, Kalt W, Magee JB, et al. Resveratrol, pterostilbene, and piceatannol in vaccinium berries. J Agric Food Chem. 2004 Jul 28;52(15):4713-9.

13. Lazze MC, Pizzala R, Savio M, et al. Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Mutat Res. 2003 Feb 5;535(1):103-15.

14. Available at: http://www.lef.org/magazine/mag2005/jan2005_cover_green_tea_01.htm. Accessed: September 6, 2006.

15. Fassina G, Vene R, Morini M, et al. Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallcatechin-3-gallate. Clin. Cancer Res. 2004 Jul 15;10(14):4865-73.

16. Yang CS, Chung JY Li C, et al. Mechanisms of inhibition of carcinogenesis by tea. Biofactors. 2000 13:(1-4):73-9.

17. Fujiki H. Two stages of cancer prevention with green tea. J Cancer Res Clin Oncol 1999 Nov;125(11):589-97.

18. Xu JZ, Yeung SY, Chang Q, et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr. 2004 Jun;91(6):873-81.

19. Miyazawa, T. Absorption, metabolism and antioxidative effects of tea catechins in humans. Biofactors. 2000 13(1-4):55-9.

20. Xie D, Liu G, Zhu G, et al. [-]-Epigallocatechin-3-gallate protects cultured spiral ganglion cells from H202-induced oxidizing damage. Acta Otolaryngol. 2004 May;124(4): 464-70.

21. Beliveau, R, Gingras, D. Green tea prevention and treatment of cancer by nutriceuticals. Lancet. 2004 Sep 18;364(9439):1021-2.

22. Kotanidou A. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med. 2003 Mar 15; 165(6):818-23.

23. Kimata M. Effects of luteolin and other flavenoids on IgE-mediated allergic reactions. Planta Med. 2000 Feb; 66(1):25-9.

24. Surh YJ, Chun KS, Cha HH, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: downregulation of Cox-2 and Inos through suppression of NFkappaB activation. Mut Res. 2001 480;243-268.

25. Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002 May 15;364(Pt 1):301-7.

26. Faulkner K, Mithen R, Williamson G. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli. Carcinogenesis. 1998 Apr;19(4):605-9.

27. Vang O, Mortensen J, Andersen O. Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. Metabolism. 2001 Oct;50(10):1130-5.

28. Smith TK, Mithen R, Johnson IT. Effects of brassica vegetable juice on the induction of apoptosis of aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis. 2003 Mar;24(3): 491-5.

29. Jackson SJ, Singletary KW. Sulforaphane: a naturally occurring mammary carcinoma mitosis inhibitor, which disrupts tubulin polymerization. Carcinogenesis. 2004 Feb;25(2):219-27.

30. Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci. 1997 94:11149-51.

31. Talalay P, Fahey JW. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr. 2001 Nov;131(11 Suppl):3027S-3033S.

32. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci. 1997 94:10367-72.

33. Hanausek M, Walaszek Z, Slaga TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003 Jun;2(2):139-44.

34. Walaszek Z, Szemraj J, Narag M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and potential use in cancer prevention. Cancer Detect Prev. 1997 21(2):178-90.

35. Walaszek Z, Hanausek M, Sherman U, et al. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Lett. 1990 Jan;49(1):51-7.

36. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413-20.

37. Wilcox, JK, Catignani, GL, Lazarus, S. Tomatoes and cardiovascular health. Crit Rev Food Sci Nutr. 2003 43(1):1-18.

38. Ahuja KD, Ashton EL, Ball MJ. Effects of lipid-lowering, carotenoid-controlled diets on the oxidative modifications of low-density lipoproteins in free-living humans. Clin Sci. [Lond] 2003 Sep;105(3): 355-61.

39. Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys. 2004 Oct 1;430(1):127-34.

40. Visioli F, Galli C. Biological properties of olive oil phytochemicals. Cri Rev Food Sci Nutr. 2002 42(3):209-21.

41. Valavanidis A, Nisiotou C, Papageoriou Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

42. Ranalli A, Lucera L, Contento S. Antioxidizing potency of phenol compounds in olive mill wastewater. J Agric Food Chem. 2003 Dec 17;51(26):7636-41.

43. Valavanidis A, Nisiotou C, Papageoriou Y, et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.

44. Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9.

45. Paiva-Martins F, Gordon MH, Gameiro P. Activity and location of olive oil phenolic antioxidants in liposomes. Chem Phys Lipids. 2003 Jun;124(1):23-36.

46. Haban P, Klvanova J, Zidekova E, et al. Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects. Med. Sci. Monit. 2004 Apr;10(4):I49-I54.

47. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans – a review. Eur J Clin Nutr. 2004 Jun;58(6):955-65.

48. Parker RS, Sontag TJ. Cytochrome P-450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem. 2002 Jul 12;277(28):25290-6.

49. Meier R, Tomizaki T, Schulze-Briese C, et al. The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol. 2003 Aug 15;331(3:725-34.

50. Ikeda S, Kagaya M, Kobayashi K, et al. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nutr Sci Vitaminol [Tokyo]. 2003 Aug;49(4):270-6.

51. Kang MH, Naito M, Sakai K, et al. Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro. Life Sci. 2000 66(2):161-71.

52. Kang MH, Naito M, Tsujihara N, et al. Sesamolin inhibits lipid peroxidation in rat liver and kidney. J Nutr. 1998 Jun;128(6):1018-22.

53. Christen S, Woodall AA, Shigenaga MK, et al. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci. USA 1997 Apr;94(7):3217-22.

54. Grant KE, Chandler RM, Castle AL, et al. Chromium and Exercise Training: Effect on Obese Women. Med Science Sports Exer. 1997 29:992-8.

55. Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens. 1999 Aug;12(8 Pt 1):747-56.

56. Zhang H, Osada K, Maebashi M, et al. A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. J Nutr Sci Vitaminol (Japan). 1996 Dec;42(6):517-26.

57. Koutsikos D, Fourtounas C, Kapetanaki A, et al. Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Renal Failure (USA). 1996 Jan;18(1):131-7.

58. Pacheco-Alvarez D, Solorzano-Vargas RS, Del Rio, AL. Biotin in metabolism and its relationship to human disease. Arch Med Res. 2002 Sep-Oct;33(5):439-47.

59. Koike M, Koshizuka K, Yang R, et al. 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May-Jun;19(3A):1689-97.

60. Hisatake J, O’Kelly J, Uskokovic MR, et al. Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood. 2001 Apr 15;97(8):2427-33.

61. Dietrich T, Joshipura KJ, Dawson-Hughes B, et al. Association between serum concentrations of 25-hydroxyvitamin D and periodontal disease in the U.S. population. Am J Clin Nutr. 2004 Jul;80(1):108-13.

62. Doetsch AM, Faber J, Lynnerup N, et al. The effect of calcium and vitamin D-3 supplementation on the healing of the proximal humerus fracture: a randomized placebo controlled study. Calcif Tissue Int. 2004 Sep;75(3):183-8.

63. Harwood RH, Sahota O, Gaynor K, et al. A randomized controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham neck of femur study. Age Ageing. 2004 Jan;33(1):45-51.