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Table of Contents

Life Extension Magazine May 2009

How to Circumvent 17 Independent Heart Attack Risk Factors

By William Faloon

HEART ATTACK RISK FACTOR #17: Oxidized LDL

Optimal Blood Level: Commercial blood tests are not yet available at affordable prices to measure oxidized LDL. Aging individuals should assume their endogenous antioxidant levels (superoxide dismutase, catalase, and glutathione) are being depleted and that the oxidation of their LDL (low-density lipoprotein) is progressively worsening.

The over-promotion of “statin” drugs has resulted in today’s cardiologists focusing on reducing their patient’s LDL and total cholesterol levels. Pharmaceutical company advertising makes it appear as if the only cause of atherosclerosis is excess LDL and cholesterol.

Beginning in 1979, however, researchers made discoveries indicating that the oxidation of LDL results in severe arterial damage. Thousands of studies now reveal how oxidized LDL contributes to the entire atherosclerotic process from start to finish.302

Drug options: Statin drugs help protect against LDL oxidation; however, by inhibiting coenzyme Q10 synthesis, they deprive the body of one of its most important protectors against LDL oxidation.

Nutrient options: Most Life Extension members take nutrients that have been shown to significantly reduce LDL oxidation such as gamma tocopherol,303,304 sesame lignans,305 and lycopene.306,307 A number of studies document the ability of ubiquinol CoQ10 to protect against LDL oxidation better than lycopene, alpha tocopherol, and other lipid-soluble antioxidants.308 Perhaps no other nutrient has demonstrated better anti-LDL oxidation effects than pomegranate. In a clinical study, human subjects taking pomegranate showed a remarkable 90% reduction in the LDL basal oxidative state.50 There are standardized pomegranate supplements that provide the active constiutuents shown to reduce LDL oxidation. The usual dose is 400-500 mg of these standardized pomegranate capsules a day. The suggested dose for ubiquinol to reduce LDL oxidation is 100-200 mg a day.

Dietary options: The term postprandial oxidative stress means the oxidation that occurs after ingesting a meal. The higher the calorie, sugar, and fat content of the meal, the greater the level of post-meal oxidative stress. Reduce calorie content and take antioxidant supplements with each meal. Some people also consume polyphenol-rich beverages such as green tea, red wine, or pomegranate juice with meals to reduce postprandial oxidative stress.50,203,242,309 Beware of the high sugar calories in red wine and pomegranate juice.

Hormone options: The hormones melatonin and DHEA confer significant protection against LDL oxidation. As these hormones decline with normal aging, LDL oxidation increases, as does heart attack and stroke risk. Aging humans can supplement with melatonin doses as low as 300 mcg all the way up to 10-20 mg. Women usually need only modest DHEA dosing (15-25 mg in the morning), whereas men usually need 50 mg of DHEA each morning and sometimes higher. A DHEA blood test enables one to restore their DHEA to the optimal youthful range of 500-640 mcg/dL for men and 250-380 mcg/dL for women. Those with hormone-sensitive cancers are often advised to avoid DHEA.

Virtually No One Should Be Having Heart Attacks Today!

A question that future medical historians may ask is why so many people kept having heart attacks and strokes when proven ways existed to detect and correct the known risk factors.

Based on decades of intensive scientific research, the underlying causes of heart attack and stroke are not a mystery. For reasons that relate to apathy and ignorance, along with drug company propaganda, the majority of aging humans are walking around with a time bomb (coronary atherosclerosis) ticking in their chests. Many are doing nothing to prevent heart attack, while others are making such partial efforts that they are only postponing the inevitable.

I spent an inordinate amount of time assembling the data to write this article because I am shocked that so many dedicated Life Extension members are failing to correct for all 17 of these proven vascular disease risk factors. Please remember, if you do almost everything right, but ignore even one of these 17 risk factors, you subject yourself to the horrific consequences of blockage of critical arteries that carry blood to your heart, brain, and kidneys.

It is my sincere desire to never again hear from a health-conscious person that they have been diagnosed with coronary artery occlusion. That’s why we have made comprehensive blood testing available at ultra-low prices.

With the data presented in this article, you can order low-cost blood tests, find out what your heart attack vulnerabilities are, and take immediate corrective actions. You should also make sure you know your blood pressure and take whatever steps are needed to keep it at 115/75 mmHg or lower (there are exceptions to this, such as those suffering from diabetic and certain kidney disorders).

To order a panel of comprehensive blood tests at the lowest prices of the year, call 1-800-208-3444 or log on to www.lef.org/blood. Please order these tests by June 1, 2009 to save more than 80% compared with what commercial labs charge.

To view the comprehensive blood test panels available to Foundation members, visit the Blood Test link above.

If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-800-226-2370.

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