Life Extension Magazine
Life Extension Magazine June 2010
As We See It

Startling Low Testosterone Blood Levels in Male Life Extension Members


By William Faloon
William Faloon
William Faloon

Aging is accompanied by reduced levels of hormones required to sustain life.

As testosterone levels decline in men, their risk of dying markedly increases.1-3

Heart disease,4-8 osteoporosis,9-11 and muscle wasting12-14 are strongly linked to testosterone deficiency, as are chronic inflammatory15,16 and neurodegenerative disorders.17,18 Most doctors are surprised to learn that men with low testosterone show an increased incidence of prostate cancer.19-25

Long before life prematurely ends, testosterone deficit can manifest in the form of psychological disturbances such as depression,26-29 reduced sexual desire,30-33 and a loss of sense of well being.29,34

We at Life Extension® have long urged male members to have their testosterone blood levels tested. A pooled analysis of 7,619 free testosterone blood tests has uncovered an epidemic of testosterone deficits in male Life Extension members.

The encouraging news is that restoring testosterone to youthful ranges can easily be accomplished at minimal cost.

What are Optimal Free Testosterone Levels?

The number of men who suffer testosterone deficiency is so high that laboratory reference ranges accept ridiculously low levels as “normal.”

What are Optimal Free Testosterone Levels?

We at Life Extension suggest that men maintain their free testosterone in the range of 20 to 25 pg/mL of blood.35 Others with expertise in this area believe free testosterone as low as 15 pg/mL is adequate.36

Conventional blood labs, on the other hand, say aging men are alright with as little as 6.6 pg/mL of free testosterone in their blood—an absurdly low level!

Mainstream medicine’s ignorance regarding the need to maintain free testosterone in the higher ranges is a significant cause of premature disability and death in aging men.

(Note: Free testosterone is the biologically active form of this hormone measured in the blood. Total testosterone blood levels are not as reliable an indicator of an aging man’s testosterone status as free testosterone.)

Life Extension Members Not Immune From Testosterone Deficit

Most people are in a state of denial as to how long nature intends us to live. A 30 to 40 year old man is often shocked when his blood test results uncover strikingly low free testosterone levels.

In our analysis of male members aged 40-49 years, the mean free testosterone blood level was only 12.4 pg/mL. Those aged 30-39 years did not fare that much better, with mean free testosterone levels of only 12.8 pg/mL.

Table 1 below shows how much free testosterone levels decrease with age. Men aged 70 and higher have free testosterone blood levels of only 8.9 pg/mL (Table 1).

Table 1.
Free Testosterone(pg/mL)

Age Groups

Mean

Median

30 to 39

12.84

11.80

40 to 49

12.42

11.10

50 to 59

11.38

10.50

60 to 69

10.71

9.40

70 Plus

8.89

7.90

All Groups

10.66

9.50

As I will explain next, even these disappointedly low numbers are still better than the average population. That’s because many Life Extension members take steps to maintain higher free testosterone levels.

Shocking Percentages of Testosterone Deficiency

I have reviewed hundreds of testosterone blood tests and consistently observed less than optimal levels. When I saw the mean findings from free testosterone blood tests of Life Extension members, I was not totally surprised.

As Table 2 below reveals, only 4.2% of men had high optimal free testosterone blood levels. Another 9.6% of the men were in the mid-range of 15 to 22 pg/mL.

Table 2.
Free Testosterone

Age Groups

<15 pg/mL

15-22 pg/mL

>22 pg/mL

All

30 to 39

2.3%

0.6%

0.2%

3.1%

40 to 49

8.9%

1.8%

0.6%

11.3%

50 to 59

22.0%

3.2%

1.1%

26.3%

60 to 69

28.5%

2.9%

1.5%

32.9%

70 Plus

24.5%

1.1%

0.8%

26.4%

All Groups

86.3%

9.6%

4.2%

100.0%

A startling 86% of the men had less than 15 pg/mL of free testosterone, placing them at high risk for virtually every age-related disease.

These findings, obtained from pooled blood test results of 7,619 men, provide an intriguing opportunity to rescue the collapsing health system this country faces. If men start paying as much attention to their testosterone blood levels as they do cholesterol, the incidence of degenerative disease will plummet!

How Testosterone Protects Against Heart Attacks

How Testosterone Protects Against Heart Attacks

Most people know that higher blood levels of HDL protect against atherosclerosis and subsequent heart attack. What few understand is the critical role that testosterone plays in enabling HDL to remove built-up cholesterol away from the arterial wall.

HDL removes cholesterol from the arterial wall and returns it to the liver for safe disposal via a process known as reverse cholesterol transport. Testosterone enhances HDL-induced reverse cholesterol transport from the arterial wall.37 That is one of testosterone’s unique and life saving anti-atherosclerotic effects.

While a person can reduce their arterial wall exposure to cholesterol through healthier diets and by taking certain drugs, the average person still synthesizes about 650 mg every day of cholesterol in their peripheral tissues (outside of the liver). If there is any distortion in the HDL-mediated removal of cholesterol (i.e. reverse cholesterol transport) from the arterial wall, the consequence is atherosclerosis.38

Said differently, testosterone is required for optimal transport of excess cholesterol from our tissues and blood vessels to our liver for processing and disposal. In the testosterone-deficient state, reverse cholesterol transport is compromised, and excess cholesterol cannot be removed from the arterial wall.39-41

How Testosterone Affects HDL
  • Testosterone elevates the hepatic lipase enzyme that the liver needs to safely clear the body of excess cholesterol.
  • The liver contains a receptor called scavenger receptor B1 that acts to stimulate cholesterol uptake for processing and disposal. Testosterone beneficially increases scavenger receptor B1.37
  • Furthermore, a liver enzyme called hepatic lipase functions to remove phospholipids from the surface of HDL and helps enhance the uptake of these HDL-derived lipids by scavenger receptor B1.47,48 Testosterone increases the activity of hepatic lipase.48
  • By increasing both scavenger receptor B1 and hepatic lipase activities, testosterone facilitates an increase in reverse cholesterol transport, a process that removes excess cholesterol from the tissues and carries it to the liver for processing and disposal.39
  • The important take home point is the critical role of reverse cholesterol transport in enabling HDL to protect against atherosclerosis.

HDL and free testosterone levels often plummet in aging humans.42,43 The combination of low HDL and low testosterone virtually guarantees an explosion in demand for vascular stents and drugs that earn tens of billions of dollars in profits each year for pharmaceutical behemoths.

Under optimal circumstances, HDL efficiently removes cholesterol from arterial walls and then transports it (via reverse cholesterol transport) to the liver for elimination (mostly through the bile duct into the intestines). When there is a deficiency of testosterone, HDL is less efficient in removing debris from the arterial wall and the liver is less efficient in breaking down cholesterol-laden HDL from the bloodstream.

Armed with this knowledge, you can now see past the charade perpetrated by the medical establishment that still questions the value of testosterone supplementation.

Numerous well-controlled human studies show that higher testosterone levels play a critical role in maintaining healthy blood flow throughout the body by accelerating reverse cholesterol transport—there by helping to prevent atherosclerosis.44,45

Natural Hormones Slash Heart Disease Mortality!

Hormone Status

Three-Year Survival Rate

High levels of DHEA, testosterone, and IGF-1

83%

Deficiency in one hormone (DHEA, testosterone, or IGF-1)

74%

Deficiency in two hormones (DHEA, testosterone, or IGF-1)

55%

Deficiency in all three hormones (DHEA, testosterone, and IGF-1)

27%

A landmark study analyzed the relationship of natural hormones (free testosterone, DHEA, and insulin-like growth factor-1 [IGF-1]) to death rates in men suffering from chronic heart failure.4 The findings from this study are tabulated on the chart in this box. As one can see, more men die when any of these hormones are deficient. This same chart shows catastrophic mortality when two or more of these hormones are deficient.4

A large number of studies reveal that higher testosterone or dehydroepiandro-sterone (DHEA) levels are associated with reduced heart disease risk.49-54 DHEA is a low-cost dietary supplement, while IGF-boosting nutrients and natural testosterone cream are available to Americans at affordable prices.

Cardiac drugs generate outrageous profits for pharmaceutical interests. Pharmaceutical companies thus face huge economic losses if too many Americans use natural hormones to reduce their reliance on expensive prescription drugs.

Low Testosterone Sharply Increases Coronary Artery Disease Risk

The relationship between low testosterone and increased coronary artery disease incidence has been the featured topic of several covers of Life Extension Magazine® over the past two decades.

One study evaluated men under age 45 who presented with coronary artery disease compared with an age-matched control group. The findings revealed that even moderately reduced free testosterone blood levels (below 17.3 pg/mL of blood) in these younger men resulted in a 3.3-fold greater risk of developing premature coronary artery disease compared with men who had values above 17.3 pg/mL.46

To put this testosterone blood reading in perspective, aging men who don’t use testosterone-boosting nutrients or drugs often have very low free testosterone blood levels (less than 10 pg/mL of blood). These same men often have low HDL blood test readings in the danger zone (less than 40-50 mg/dL). Is it any wonder that despite aggressive use of statin drugs and other advances in cardiac medicine, heart attack and stroke are still today’s leading killers?

Low Testosterone Increases Prostate Cancer Risk

Fear of prostate cancer is the leading reason why aging men have shied away from restoring their free testosterone to youthful ranges. To dispel this concern, Life Extension long ago analyzed every published study and found there is no basis for asserting that testosterone causes prostate cancer.55-60

Low Testosterone Increases Prostate Cancer Risk
Click here to view

Our observations from the thousands of blood tests we perform each year for members confirm this. What we found is that men with low testosterone appear to be more likely to contract prostate cancer.

In the landmark book, Testosterone for Life (McGraw-Hill, 2008), Harvard professor Abraham Morgentaler thoroughly discredited the notion that testosterone causes prostate cancer.61

What came as a bombshell to the medical establishment was the compilation by Dr. Morgentaler of scientific facts showing that men with low testosterone levels have an increased percentage of prostate cancer-positive biopsies.62,63

To further help dispel the myth that higher testosterone levels increase PSA levels (and presumably prostate cancer risk), the two charts on the below compiled from our blood test analysis clearly show that as free testosterone levels decline in aging men, their PSA levels sharply increase.

What Are Your Free Testosterone Levels?

While our data analysis of 7,619 blood tests of male Life Extension members showed less-than-optimal free testosterone levels, there was a considerable amount of individual variability.

Low Testosterone Increases Prostate Cancer Risk
Click here to view

Some 60-year old men, for example, had relatively youthful (high) free testosterone levels, while others were dangerously low.

An aging male does not have to guess what his free testosterone level is. Blood tests provide an accurate measurement to ascertain if testosterone supplementation is warranted and what dose should be initially used.

Blood tests also measure PSA (prostate-specific antigen) to help rule out prostate cancer. While testosterone does not cause prostate cancer, men with pre-existing prostate malignancy are usually advised to avoid supplemental testosterone until the disease is cured.

Low-cost and Convenient Blood Testing

The high prices that commercial labs charge for comprehensive blood testing precludes most people from having them done.

Life Extension breaks down these price barriers by offering complete Male or Female Blood Test Panels at the lowest prices anywhere. Once a year, we discount the popular Male and Female Blood Test Panels down to only $199—about 80% less than what commercial labs charge. below describes the many tests included in these Male and Female Panels.

Instead of having to make a doctor’s appointment, we send you a requisition form and list of drawing stations in your area where you can go at your convenience.

The Blood Test Super Sale ends June 7, 2010, so please order your requisition kit soon to take advantage of these extra discounted prices. You can have your blood drawn anytime after receiving your requisition kit.

The results of your blood tests are mailed directly to you. If you have any questions, you are welcome to call our health advisor helpline.

Annual blood testing is the single most effective method of detecting abnormalities that can be corrected before they lead to serious illness or death. A call to 1-800-208-3444 is all you have to do to order these comprehensive tests at extra discounted prices.

For longer life,

For Longer Life

William Faloon

Male and Female Blood Test Panels

Unlike commercial blood tests that evaluate only a narrow range of risk factors, Life Extension’s Male and Female Blood Test Panels measure a wide range of blood markers that predispose people to common age-related diseases. Just look at the huge numbers of parameters included in the Male and Female Blood Test Panels:

Male
Click here to view
Female
Click here to view

Non-member retail price: $400 • Everyday member price: $269 Blood Test Super Sale member price: $199 • Enjoy these savings until June 7, 2010

To obtain these comprehensive Male or Female Panels at these low prices, call 1-800-208-3444 to order your requisition forms.
Then—at your convenience—you can visit one of the blood-drawing facilities provided by LabCorp in your area.

*If you plan to use the results of these blood tests to assist in a medically supervised weight loss program, consider adding the Thyroid add-on panel for $36.
A TSH (thyroid stimulating hormone) test is now included in the comprehensive Male and Female Panels, but those with weight problems should know their precise levels of free T3 and free T4.

References

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