1. Huang MC, Greig NH, Luo W, et al. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin Immunol. 2010 Dec 1.
2. Available at: http://aaas.confex.com/aaas/2010/webprogram/Paper1085.html. Accessed February 7, 2011.
3. Palgan K, Palgan I. Thalidomide—new prospective therapy in oncology. Wiad Lek. 2003;56(9-10):455-9.
4. Moraes M, Russo G. Thalidomide and its dermatologic uses. Am J Med Sci. 2001 May;321(5):321-6.
5. Knight R. IMiDs: a novel class of immunomodulators. Semin Oncol. 2005 Aug;32(4 Suppl 5):S24-30.
6. Anderson KC. Lenalidomide and thalidomide: mechanisms of action—similarities and differences. Semin Hematol. 2005 Oct;42(4 Suppl 4):S3-8.
7. Blum W, Klisovic RB, Becker H, et al. Dose escalation of lenalidomide in relapsed or refractory acute leukemias. J Clin Oncol. 2010 Nov 20;28(33):4919-25.
8. Dimopoulos MA, Terpos E. Lenalidomide: an update on evidence from clinical trials. Blood Rev. 2010 Nov;24 Suppl 1:S21-6.
9. Li S, Gill N, Lentzsch S. Recent advances of IMiDs in cancer therapy. Curr Opin Oncol. 2010 Nov;22(6):579-85.
10. Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32.
11. Amato RJ, Hernandez-McClain J, Saxena S, Khan M. Lenalidomide therapy for metastatic renal cell carcinoma. Am J Clin Oncol. 2008 Jun;31(3):244-9.
12. Patel PH, Kondagunta GV, Schwartz L, et al. Phase II trial of lenalidomide in patients with metastatic renal cell carcinoma. Invest New Drugs. 2008 Jun;26(3):273-6.
13. Corti A, Giovannini M, Belli C, Villa E. Immunomodulatory agents with antivascular activity in the treatment of non-small cell lung cancer: focus on TLR9 agonists, IMiDs and NGR-TNF. J Oncol. 2010;2010:732680.
14. Dalgleish A, Galustian C. The potential of immunomodulatory drugs in the treatment of solid tumors. Future Oncol. 2010 Sep;6(9):1479-84.
15. Davies F, Baz R. Lenalidomide mode of action: linking bench and clinical findings. Blood Rev. 2010 Nov;24 Suppl 1:S13-9.
16. Heise C, Carter T, Schafer P, Chopra R. Pleiotropic mechanisms of action of lenalidomide efficacy in del(5q) myelodysplastic syndromes. Expert Rev Anticancer Ther. 2010 Oct;10(10):1663-72.
17. Saloura V, Grivas PD. Lenalidomide: a synthetic compound with an evolving role in cancer management. Hematology. 2010 Oct;15(5):318-31.
18. Nagel JE, Chopra RK, Chrest FJ, et al. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest. 1988 Apr;81(4):1096-102.
19. Ladizinski B, Shannon EJ, Sanchez MR, Levis WR. Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders. J Drugs Dermatol. 2010 Jul;9(7):814-26.
20. Kotla V, Goel S, Nischal S, et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36.
21. Available at: http://www.sciencedaily.com/releases/2010/12/101213140945.htm. Accessed January 19, 2011.
22. Effros RB. Ageing and the immune system. Novartis Found Symp. 2001;235:130-9; discussion 139-45, 146-9.
23. Caruso C, Buffa S, Candore G, et al. Mechanisms of immunosenescence. Immun Ageing. 2009 Jul 22;6:10.
24. Rea IM, Stewart M, Campbell P, Alexander HD, Crockard AD, Morris TC. Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age. Gerontology. 1996;42(2):69-78.
25. Pawelec G, Derhovanessian E, Larbi A. Immunosenescence and cancer. Crit Rev Oncol Hematol. 2010 Aug;75(2):165-72.
26. Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther. 2004;6(4):131-9.
27. Agius E, Lacy KE, Vukmanovic-Stejic M, et al. Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med. 2009 Aug 31;206(9):1929-40.
28. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan;9(1):57-62.
29. Marko MG, Ahmed T, Bunnell SC, et al. Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation. J Immunol. 2007 Feb 1;178(3):1443-9.
30. Caruso C, Candore G, Cigna D, et al. Cytokine production pathway in the elderly. Immunol Res. 1996;15(1):84-90.
31. Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol. 2005 Oct;17(5):370-7.
32. Gillis S, Kozak R, Durante M, Weksler ME. Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest. 1981 Apr;67(4):937-42.
33. Kilpatrick RD, Rickabaugh T, Hultin LE, et al. Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol. 2008 Feb 1;180(3):1499-507.
34. Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood. 2000 May 1;95(9):2860-8.
35. Wack A, Cossarizza A, Heltai S, et al. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol. 1998 Sep;10(9):1281-8.
36. Gregg R, Smith CM, Clark FJ, et al. The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin Exp Immunol. 2005 Jun;140(3):540-6.
37. Lages CS, Suffia I, Velilla PA, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008 Aug 1;181(3):1835-48.