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Life Extension Magazine April 2011
As We See It

What We Are Doing To Reverse Your Biological Age

By William Faloon
Seeking to Vastly Accelerate Aging Research

Seeking to Vastly Accelerate Aging Research

We live in a fascinating era. Throughout history there were no validated methods to slow human aging, let alone reverse it. Today, scientists are meticulously investigating methods to enable our aging bodies to grow younger. If they succeed, then we might be the last generation to succumb to aging and the horrific diseases that accompany it.

Long before the Nature study was published on November 28, 2010, I brought up a concept while meeting with scientists at a medical conference in December 2008.25

Everyone acknowledged that potential advances might enable us to reverse the aging process we are all suffering. The problem is that no coordinated plan existed amongst the various scientific disciplines to collectively harness this technology into a near-term reality.

I proposed that we emulate what the United States did during World War II to rapidly develop the atomic bomb. I reasoned that if we instill a sense of confidence and urgency, we can collectively implement a “Manhattan Project” aimed at finding ways to reverse the festering aging process.

Several volunteers followed up on my suggestion and put together a “Longevity Summit” that consisted of some of the world’s top anti-aging researchers.

This longevity summit titled The Manhattan Beach Project was held November 13–15, 2009, in Manhattan Beach, CA.26 The expenses were high because we had to fly gerontology experts in from around the world and cover hotel fees and video recording. The Life Extension Foundation funded the entire cost, which amounted to around $60,000.

The first two days of this summit featured presentations by researchers who revealed their scientific roadmap for initiating and achieving age reversal. Some of these scientists had been quietly developing their technologies for many years.

The last day was a roundtable discussion among the wealthy attendees, the scientists, and some very creative minds. The purpose of this brainstorm session was to develop plans to fund these anti-aging research initiatives that our lives so heavily depend on.

The following consensus was reached:

  1. In order to provide sufficient near-term funding to the most promising anti-aging research projects, about $100 million will need to be raised beyond what is already being spent by the Life Extension Foundation and wealthy individuals who are currently giving money to gerontology scientists.
  2. There are enough interested individuals today who are cumulatively able to provide this level of funding with moderate personal investments.
  3. A company should be formed to not only raise and allocate these funds, but to also raise public awareness that a credible effort is being made to gain control over human aging.

A New “Age-Reversal” Initiative

The first step in implementing the Manhattan Beach Project was to assemble a knowledgeable and experienced Board of Directors to assure that the new company would be competently managed.

A New “Age-Reversal” Initiative

The next challenge was lining up the initial seed financing to get this company off the ground. Initially, $2 million was raised, of which the Life Extension Foundation provided $500,000.

The primary motivation for people to be involved with this company is that the research it supports could lead to breakthroughs in the control of human aging that could enable them to live much longer.

What I hope will be different with this company than any other are the expectations of these people. While there is a chance that the development of patented anti-aging therapies could yield considerable profits, that was not the main reason we thought individuals might participate.

From the perspective of most Life Extension members, the development of validated methods that would enable humans to grow biologically younger is far more valuable than all the money in the world.

The company is set up to assist, both financially and technologically, companies that are engaged in research that may lead to the control of human aging.

Not all of these age-reversal initiatives will pan out. But if just one led to the development of a validated method to reverse the course of aging, then every participant (and mankind itself) would benefit.

Age Reversal Was Not Thought Possible

When Life Extension was founded, most people did not believe that reversing human aging could ever happen.

We proved them wrong last year by showing that at least at the cellular level, it is possible to re-program genes to prompt human cells to go back in time. This discovery was announced in the June 2010 issue of Life Extension Magazine.27

A New “Age-Reversal” Initiative

If one looks at the rapid technology advances we enjoy today, the probability of conquering aging can be easily analogized. Just think of the progress that has been made in other fields:

  • From counting on fingers to supercomputers.
  • Riding on horse and buggies to flying on jet planes.
  • Waiting for the pony express to instant email.
  • Stage plays to satellite TV.

One reason we are confident that age reversal is possible in our lifetime is the law of accelerating returns, which means that as scientists reach higher technological milestones, the accumulated knowledge base can be used to rapidly move up the scientific ladder.

At the Manhattan Beach Project summit in November 2009, a number of scenarios for slowing or reversing aging were presented by eminent scientific authorities. The consensus amongst the participants was that it may be possible to cure aging in our lifetime. This prediction was made before the landmark aging-reversal study was published in Nature just one year later (in November 2010).

A New “Age-Reversal” Initiative

We reasoned that if we could move up the next big anti-aging breakthrough by even a few years, this will mean the difference between life and death to many of those reading this article. That is why we view this matter with such a sense of urgency.

Where We Stand Today

The challenge we face is turning around public opinion to make aging research the number one priority. We need to overcome the denial about personal extinction that plagues the vast majority of the population. Once this is accomplished, I am certain the collective efforts of the scientific community will deal with aging as efficiently as hand-held computers function today.

Life Extension is currently evaluating several programs aimed at substantially increasing funding to scientists involved in age-reversal research. Your support through membership renewals and product purchases enables us to finance ongoing scientific projects while laying the groundwork for exponential expansion of this research in the not-too-distant future.

For longer life,

For Longer Life

William Faloon

Stair-Climbing Towards Biological Immortality

With each biological discovery, the human species climbs one step further toward gaining complete control over its own life processes.

While recorded human history goes back about 10,000 years, the vast majority of scientific breakthroughs have only occurred over the past 100 years. For instance, it was not until 1953 that James Watson and Francis Crick identified the structure of DNA (for which they later won a Nobel Prize).

Prior to 1953, it would have been difficult to conceive that doctors might one day control human cellular processes as easily as computer operating systems are now engineered. Of course, back then, no one thought that computers would have ever advanced as far as they have already.

While it took 10,000 years for humans to figure out the structure of DNA (in 1953), it only required a little over 50 years to map out the entire human genome! Genes are the cell’s “operating system,” enabling young healthy cells to function flawlessly. Gene expression is unfavorably altered as we age, which is what ultimately causes us to degenerate and eventually die.

Research funded by Life Extension and others has identified specific genes that are adversely expressed as cells grow old. Once scientists perfect methods to control gene expression, we believe it will be possible to “engineer” DNA so that our cells will be biologically immortal and completely resistant to cancer. The reason we take supplements like vitamin D28-31 and resveratrol32-34 is the favorable effect on gene expression these nutrients induce.

So from 1953, we have gone from uncovering the basic structure of DNA to developing sophisticated DNA gene expression assays. We are now at a stage of exerting partial control over some of the genes that cause us to age.

Based on this rapid progress, more “stairs have been climbed” in the scientific discipline of cellular engineering over the past 58 years than what mankind accomplished in the prior 10,000 years. It is this velocity of advancement that is enabling renowned scientists to predict that biological immortality is not only a possibility, but one that could occur in the lifetimes of some of those reading this article now!

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