Whole Body Health Sale

Life Extension Magazine

Life Extension Magazine October 2012
Report

Restoring Cellular Energy Metabolism

By Kirk Stokel

References

1. Miyoshi N, Oubrahim H, Chock PB, Stadtman ER. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA. 2006 Feb 7;103(6):1727-31. Epub 2006 Jan 27.

2. Kohlhaas M, Maack C. Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure. Trends Cardiovasc Med. 2011 Apr;21(3):69-73.

3. Available at: http://naturalmedicinejournal.net/pdf/NMJ_FEB10_NP.pdf. Accessed July 23, 2012.

4. Barsotti C, Ipata PL. Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain. Biochem Pharmacol. 2002 Jan 15;63(2):117-22.

5. Omran H, McCarter D, St Cyr J, Luderitz B. D-ribose aids congestive heart failure patients. Exp Clin Cardiol. 2004 Summer;9(2):117-8.

6. Perlmutter NS, Wilson RA, Angello DA, Palac RT, Lin J, Brown BG. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med. 1991 Feb;32(2):193-200.

7. Seifert JG, Subudhi AW, Fu MX, et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009 Jun;12(3):690-3.

8. Freeman ML, Mertens-Talcott SU, St Cyr J, Percival SS. Ribose enhances retinoic acid-induced differentiation of HL-60 cells. Nutr Res. 2008 Nov;28(11):775-82.

9. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 3;82(5A):2K-13K.

10. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 3;82(5A):2K-13K.

11. Sato H, Ueki M, Asaga T, Chujo K, Maekawa N. D-ribose attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. Tohoku J Exp Med. 2009 May;218(1):35-40.

12. Nishiyama J, Ueki M, Asaga T, Chujo K, Maekawa N. Protective action of D-ribose against renal injury caused by ischemia and reperfusion in rats with transient hyperglycemia. Tohoku J Exp Med. 2009 Nov;219(3):215-22.

13. Pauly DF, Pepine CJ. D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther. 2000 Oct;5(4):249-58.

14. Pliml W, von Arnim T, Stablein A, Hofmann H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet. 1992 Aug 29;340(8818): 507-10.

15. Kendler BS. Supplemental conditionally essential nutrients in cardiovascular disease therapy. J Cardiovasc Nurs. 2006 Jan-Feb;21(1):9-16.

16. Sinatra ST. Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. Altern Ther Health Med. 2009 May-Jun;15(3):44-52.

17. Lopaschuk GD. Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. Presse Med. 1998 Dec 12;27(39):2100-4.

18. Pauly DF, Johnson C, St Cyr JA. The benefits of ribose in cardiovascular disease. Med Hypotheses. 2003 Feb;60(2):149-51.

19. Sinatra ST. Metabolic cardiology: the missing link in cardiovascular disease. Altern Ther Health Med. 2009 Mar-Apr;15(2):48-50.

20. Hegewald MG, Palac RT, Angello DA, Perlmutter NS, Wilson RA. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol. 1991 Dec;18(7):1671-81.

21. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail. 2003 Oct;5(5):615-9.

22. Omran H, McCarter D, St Cyr J, Luderitz B. D-ribose aids congestive heart failure patients. Exp Clin Cardiol. 2004 Summer;9(2):117-8.

23. Schneider HJ, Rossner S, Pfeiffer D, Hagendorff A. D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats. Int J Cardiol. 2008 Mar 28;125(1):49-56.

24. Sawada SG, Lewis S, Kovacs R, et al. Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study. Cardiovasc Ultrasound. 2009;7:5.

25. MacCarter D, Vijay N, Washam M, Shecterle L, Sierminski H, St Cyr JA. D-ribose aids advanced ischemic heart failure patients. Int J Cardiol. 2009 Sep 11;137(1):79-80.

26. Chigrinskiy EA, Conway VD. Protective effect of D-ribose against inhibition of rats testes function at excessive exercise. Journal of Stress Physiology & Biochemistr. 2011;7(3):242-9.

27. Barsotti C, Ipata PL. Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain. Biochem Pharmacol. 2002 Jan 15;63(2):117-22.

28. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006 Nov;12(9):857-62.

29. Eisinger J, Plantamura A, Ayavou T. Glycolysis abnormalities in fibromyalgia. J Am Coll Nutr. 1994 Apr;13(2):144-8.

30. Le Goff P. Is fibromyalgia a muscle disorder? Joint Bone Spine. 2006 May;73(3):239-42.

31. Gebhart B, Jorgenson JA. Benefit of ribose in a patient with fibromyalgia. Pharmacotherapy. 2004 Nov;24(11):1646-8.

32. Martin CM. The mysteries of restless legs syndrome. Consult Pharm. 2007 Nov;22(11):907-24.

33. Bayard M, Avonda T, Wadzinski J. Restless legs syndrome. Am Fam Physician. 2008 Jul 15;78(2):235-40.

34. Guieu R, Sampieri F, Pouget J, Guy B, Rochat H. Adenosine in painful legs and moving toes syndrome. Clin Neuropharmacol. 1994 Oct;17(5):460-9.

35. Laisalmi-Kokki M, Pesonen E, Kokki H, et al. Potentially detrimental effects of N-acetylcysteine on renal function in knee arthroplasty. Free Radic Res. 2009 Jul;43(7):691-6.

36. Siems W, Quast S, Carluccio F, et al. Oxidative stress in chronic renal failure as a cardiovascular risk factor. Clin Nephrol. 2002 Jul;58 Suppl 1:S12-9.

37. Yan SF, Ramasamy R, Schmidt AM. The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease. Expert Rev Mol Med. 2009;11:e9.

38. Jang HR, Ko GJ, Wasowska BA, Rabb H. The interaction between ischemia-reperfusion and immune responses in the kidney. J Mol Med. 2009 Sep;87(9):859-64.

39. Vallon V, Osswald H. Adenosine receptors and the kidney. Handb Exp Pharmacol. 2009 (193):443-70.

40. Mentink CJ, Hendriks M, Levels AA, Wolffenbuttel BH. Glucose-mediated cross-linking of collagen in rat tendon and skin. Clin Chim Acta. 2002 Jul;321(1-2):69-76.

41. Kuo TY, Huang CL, Yang JM, et al. The role of ribosylated-BSA in regulating PC12 cell viability. Cell Biol Toxicol. 2012 Aug;28(4): 255-67.

42. Wei Y, Han CS, Zhou J, Liu Y, Chen L, He RQ. d-ribose in glycation and protein aggregation. Biochim Biophys Acta. 2012 Apr;1820(4):488-94.

43. Han C, Lu Y, Wei Y, Liu Y, He R. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One. 2011;6(9):e24623.

44. Gross M, Zollner N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr. 1991 Jan 4;69(1):31-6.

45. Vos PA, Degroot J, Barten-van Rijbroek AD, et al. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage. J Orthop Res. 2012 Mar 2.

46. Willett TL, Kandel R, De Croos JN, Avery NC, Grynpas MD. Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthritis Cartilage. 2012 Jul;20(7):736-44.