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Life Extension Magazine September 2012
In The News

Trial Will Evaluate Resveratrol in Alzheimer's Dementia

Researchers at Georgetown University and 25 other US academic institutions affiliated with the Alzheimer's Disease Cooperative Study will be conducting a phase II double-blinded, placebo-controlled trial that will test the effects of resveratrol in Alzheimer's disease patients.*

The twelve-month trial will enroll men and women age 50 and over with mild to moderate dementia diagnosed as probable Alzheimer's disease and will require one caregiver or friend for each patient. Participants will be initially assigned to 500 mg resveratrol or a placebo daily, with dosage to be increased at 13 week intervals to a maximum of 1,000 mg twice per day. Lumbar punctures, brain magnetic resonance imaging (MRI) scans, and blood and urine tests will monitor the subjects' progress over the course of ten visits. The researchers hope to determine whether supplementation with resveratrol is helpful in delaying or altering the deterioration of memory and daily function that occurs in Alzheimer's disease.

Editor's Note: The study will also test whether resveratrol improves glucose and insulin metabolism, although diabetics will not be included in the trial.

—D. Dye

Reference

* Presented ahead of a trial.

CT Scans Linked to Rise in Cancer Risk for Children

CT Scans Linked to Rise in Cancer Risk for Children

For years, Life Extension has warned of the potential risk of cancer due to the radiation caused by CT scans. Now, a recent report in The Lancet shows that the most vulnerable among us, children, may be suffering from not heeding our warning.*

The study included patients without previous cancer diagnoses who were first examined with CT scans in National Health Service (NHS) centers in England, Wales, or Scotland (Great Britain) between 1985 and 2002, when they were younger than 22 years of age. The scientists conducting the study received data for cancer incidence, mortality, and loss to follow-up from the NHS Central Registry from Jan. 1, 1985, to Dec. 31, 2008.

These documents showed a positive association between radiation dose from CT scans and leukemia and brain tumors, leading the researchers to write that the "use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukemia and doses of about 60 mGy might triple the risk of brain cancer."

—J. Finkel

Reference

* Available at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60815-0/abstract. Accessed June 19, 2012.

Whey Protein May Heal Diabetic Wounds and Restore Immune Response in Mice

It is well known that diabetes-associated complications are a major source of immune system fatigue and this may lead to higher risk for infection. Diabetes can cause poor circulation in the feet, increasing the likelihood of ulcers forming when the skin is damaged and slowing the healing of the ulcers. Whey proteins enhance immunity during childhood and have a protective effect on some immune disorders.

A recent article in BMC Immunology reveals a study done by scientists who investigated the effects of camel whey protein on the healing and closure of diabetic wounds in a type I diabetic-induced mouse model.*

Over the course of treatment, compared with untreated diabetic mice, those mice supplemented with whey protein significantly accelerated the closure of diabetic wounds by limiting inflammatory stimuli. The researchers concluded that their, "data demonstrates the benefits of whey protein supplementation for improving the healing and closure of diabetic wounds and restoring the immune response in diabetic mice." This discovery may be of critical importance in humans suffering from diabetes.

—J. Finkel

Reference

* Plant Foods Hum Nutr. 2012 May 31.

Pomegranate Juice May Improve Heart Health

Pomegranate Juice May Improve Heart Health

Researchers at Sheffield Hallam University in South Yorkshire, UK have recently concluded that pomegranate juice may improve cardiovascular risk because of the presence of antioxidant polyphenols.*

In a randomized, placebo-controlled parallel study, participants consumed 330 ml/day of pomegranate juice or a control drink for four weeks. Measurements for pulse wave velocity, blood pressure, and plasma antioxidant status were made at baseline and at four weeks. While there was no effect on pulse wave velocity, the subjects taking the pomegranate juice showed a significant fall in systolic blood pressure, diastolic blood pressure, and mean arterial pressure. This led the scientists to state that pomegranate juice supplementation has benefits for blood pressure in the short term.

—J. Finkel

Reference

* Plant Foods Hum Nutr. 2012 May 31.

Glucose Regulation Key to Lowering Diabetes Risk

Glucose Regulation Key to Lowering Diabetes Risk

Researchers involved with the Diabetes Prevention Program Research Group attempted to quantify and predict diabetes risk reduction during the Diabetes Prevention Program Outcomes Study (DPPOS) in participants who returned to normal glucose regulation at least once during the Diabetes Prevention Program (DPP) compared with those who consistently met criteria for prediabetes.*

The researchers found that diabetes risk during DPPOS was 56% lower for participants who had returned to normal glucose regulation versus those who consistently had prediabetes. This led researchers to conclude that, "prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention. Reversion to normal glucose regulation, even if transient, is associated with a significantly reduced risk of future diabetes independent of previous treatment group."

—J. Finkel

Reference

* Available at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60525-X/abstract. Accessed June 19, 2012.