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Life Extension Magazine December 2013
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Enhanced Winter Wellness Against Colds & Flu

By Michael Downey
Enhanced Winter Wellness Against Colds & Flu

It’s one of the top 10 killers in the US, causing an average estimate of over 30,000 people to die each year.1,2 It’s not heart disease or cancer or diabetes… it’s the flu.

Most people associate the flu with muscle pain, coughing, sore throat, fatigue, and other symptoms, but the flu can turn into a deadly infection.2,3

Scientists have found two ingredients that prime the immune system to defend against the onslaught of influenza and other seasonal pathogens that can result in serious illness and even death.2,4,5

The Deadly Complications of Influenza

If you think of the flu as merely a seasonal risk or inconvenience, think again. Although known for uncomfortable symptoms such as sore throat, nasal discharge, chills, fever, muscle pain, headaches, coughing, nausea, and fatigue3,6—the harsh reality is that tens of thousands of Americans die from influenza infection in an average year.

Potentially lethal results of the flu can include either direct viral pneumonia or secondary bacterial pneumonia,7,8 and complications of chronic conditions such as congestive heart failure and chronic obstructive pulmonary disease (COPD).9

Almost 90% of all American deaths caused by influenza are among those over 65 years old.10 One reason is the immune senescence suffered by virtually all aging individuals. Vaccines function by eliciting an antibody response against specific viruses . The ability to generate an antibody response to influenza vaccines is severely compromised in the elderly.11

But the elderly are not the only ones at risk of flu-related death. High-risk groups also include pregnant women, the immunocompromised, children under age two, and people who have chronic illnesses such as asthma, diabetes, heart disease.12

Shocking Flu Statistics
Shocking Flu Statistics

On average, influenza is estimated to cause over 30,000 deaths in the United States annually.1

The antibody response of elderly patients to influenza vaccine has been shown to be blunted.11

Complications of viral influenza infection may involve several organ systems.22

Flu shots fail to protect older persons from the most virulent strains up to 91% of the time.18

The flu vaccine’s effectiveness among the general population is only about 56%.18

Flu-related deaths for persons over age 85 are 16 times greater than that of slightly younger persons aged 65-69.23

Flu infection is estimated to cause more than 200,000 hospitalizations annually in the United States.22

Chronic medical conditions—such as heart disease, lung disease, diabetes, kidney disease, liver disease, dementia, and stroke—are all risk factors for potentially lethal influenza complications.12

The most frequent serious flu complications are pulmonary, such as primary influenza pneumonia, secondary bacterial pneumonia, or chronic pulmonary diseases.7-9

Influenza A caused by H5N1 virus (“avian flu”) often infects young, previously healthy persons—with a fatality rate of about 60%, usually due to respiratory failure.24

Neurologic complications of influenza, such as encephalopathy, are most common in children.25

Increased rates of schizophrenia were noted in offspring of women who had the flu in the second pregnancy trimester, implying fetal developmental brain effects.26

Abnormal cardiac findings were found in 43% of adult flu patients,suggesting influenza pneumonia may predispose patients to serious cardiac complications such as myocarditis and pericarditis.27

The Best Defense Against the Flu

Receiving an annual flu shot is an effort many individuals, particularly those over age 65, make in an attempt to prevent both influenza infection and its deadly outcomes.13 The reason is that it mobilizes what is known as adaptive or acquired immunity.14 After the body has been “primed” with specific, non-infective viruses in the form of a vaccine, the immune system can then make antibodies to protect against future infection with these viruses.14

However, for a flu vaccine to even begin to protect against the influenza virus contained within it, the vaccinated individual must first have sound immune function—so that the immune system can properly respond to stimulation by the vaccine’s antigen.15

The trouble is that, in those with weakened immunity—such as the elderly population—vaccine stimulation triggers only a limited antibody response, thus limiting the effectiveness of the vaccine.16,17

That means, despite being vaccinated, aging individuals remain highly susceptible to infection. This can be one reason why up to 91% of those 65 and over who get a flu shot may still be susceptible to getting the flu!18

But there’s good news. Scientists have recently found a way to boost the effectiveness of the flu vaccine. Exciting new evidence shows that, taken together for two weeks prior to vaccination, the amino acids L-theanine and L-cystine enhance the efficacy of the flu vaccine in certain subsets of elderly subjects.19 This delivers strong protection against the flu virus—and its deadly complications.

These two compounds do not enhance the vaccine itself; instead, they help boost the immune system’s acquired immune response, giving your body the tools it needs to effectively utilize the vaccine.19

Better Together

When these complementary amino acids were used together in animal studies, they increased immune response.4,20

In one study, researchers gave both L-theanine and L-cystine orally to mice for 10 days. Six days after infection with influenza, the treated mice had lower lung concentrations of the virus. Ten days after infection, there was a significant enhancement of key anti-influenza-virus antibodies (called immunoglobulin G or IgG).4

Scientists realized that the co-administration of L-cystine and L-theanine could restore age-related impairment of immune competence, helping to prevent influenza and other viral infections—and in turn, preventing deadly complications.4

Based on this knowledge, scientists set out to determine if these two substances could boost vaccine effectiveness by targeting (and enhancing) the immune system itself.

What You Need to Know
Boosting Vaccine Effectiveness

Boosting Vaccine Effectiveness

  • On average each year, it is estimated that over 30,000 Americans die from influenza.
  • The recommended annual flu shot protects older Americans from a virulent strain as infrequently as 9% of the time and protects the general population only 56% of the time. One of the reasons is that in the elderly, who are far more likely to have generalized weakened immunity, vaccine stimulation triggers only a limited antibody response.
  • Taken together for two weeks prior to vaccination, the amino acids L-theanine and L-cystine enhance efficacy of the flu vaccine in a subset of elderly subjects. This delivers stronger protection against both the flu virus—and its deadly complications.
  • Remarkably, this same combination has been shown to reduce the incidence of the common cold by 58%.