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Life Extension Magazine

Life Extension Magazine July 2013
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Stop Starch-Induced Glucose Surges

By Scott Rackinow
Shield Your Body from Chronically Elevated Insulin
Shield Your Body from Chronically Elevated Insulin

Anyone whose blood sugar is not under optimum control is exposed to the dangers of chronically elevated insulin levels. That’s because your body will pump out insulin so long as blood sugar levels are above normal—and can result in an insulin level that may be dangerously elevated in its effort to keep blood sugar at a normal level, making it a truly hidden danger.

Insulin, of course, is a useful and necessary hormone. It is responsible for driving blood sugar into cells, where it’s burned for energy. Without properly regulated amounts of insulin we couldn’t survive.

But insulin, like many hormones, has multiple functions. The little-known “dark side” of insulin is that it is a powerful growth factor.41 And in the healthy adult body, there’s limited usefulness in growth factors. Excessive growth factor production triggers cell replication in places we don’t want it. Insulin and other growth factors are implicated, for example, in cancer, where unregulated cellular reproduction produces deadly malignancies.42And imbalanced growth factors, including insulin, are also implicated in the thickening and poor responsiveness of smooth muscle cells lining arterial walls, contributing to cardiovascular disease.41

Excessive insulin production is the result of insulin resistance, which is another way to say “prediabetes.” High insulin levels are associated with a 37% increase in the risk of dying from cancer—whether or not you have diabetes.40,43 Doctors are finally learning to pay attention to insulin levels as well as to blood sugar levels when evaluating new treatments and when advising their patients. And they are starting to seek therapies that increase insulin sensitivity and lower overall insulin levels.44

Most antidiabetic drugs aim only to drive down blood sugar levels and have no effect on insulin; others are actually intended to increase your insulin levels in the attempt to reduce blood sugar. But transglucosidase works in part by lowering insulin levels as blood sugar normalizes.

In human studies in which healthy subjects with evidence of insulin resistance ate a test meal of white rice (high in starch), placebo recipients saw their insulin levels rise along with their after-meal blood sugars (the expected response), while those receiving transglucosidase had small decreases in insulin over the same time period.6 And in patients with diabetes, who already had elevated insulin levels, 12 weeks of transglucosidase supplementation led to significant drops in insulin concentration overall. These are remarkable findings, given that these subjects made no other changes in their diets or lifestyles.

Reduce the Impact of Diabetes

Another clinical study looked at patients who already had type II diabetes, and the researchers found that the benefits of transglucosidase are just as exciting for those with full-blown diabetes as they are for prediabetics.22

Diabetics not only have elevated blood sugar and often high insulin levels, but also have detectable evidence of advanced glycation end products in the form of hemoglobin A1c (HbA1c). This blood test is an indication of total blood sugar levels over an approximate two to three-month period.

Patients in the study received total daily doses of 900,000 units of transglucosidase, 2.7 million units of transglucosidase, or a placebo.22 Both doses produced respectable reductions in hemoglobin A1c, lowering it by an average 0.18 and 0.21%, respectively (normal measurements for this test should not exceed 5.5%).

Patients’ insulin concentrations fell significantly as well, by 2.79 and 3.59 mIU/mL, respectively.22 And while transglucosidase does not replace metformin if internal overproduction of glucose by the liver is the culprit behind elevated fasting glucose (>85 mg/dL) or elevated HbA1C (>5.5%), its dramatic insulin reductions are similar to those seen with the drug metformin, which can reduce fasting insulin by about 38% in obese, insulin-resistant people.39,40

But the benefits of transglucosidase for diabetics don’t end there. The patients taking transglucosidase also had significant increases in a beneficial cytokine called adiponectin and significant reductions in triglycerides and diastolic blood pressure.22

On the other hand, the placebo patients experienced significant increases in their body mass index (a measure of total weight for height) and also had increases in markers of fat-induced liver damage. Neither group of patients taking transglucosidase had such changes.22

If you already have type II diabetes, the availability of this novel enzyme is excellent news. It means that supplementing with transglucosidase not only helps protect against dangerous glycation reactions taking place in your tissues (which will cause heart, kidney, nerve and eye disease, given time), but also blunts excessive insulin levels (which raise your risk of cancer and cardiovascular diseases). In addition, it can also help protect you from further weight gain and other measures of poor health. And it’s all done without taking a single drug.

Dosing Enzymes
Dosing Enzymes

*Unlike many other nutrients, enzymes are dosed according to their unit of activity. One enzymatic unit is the amount of enzyme needed to convert one micromole (µmol) of a substance per minute. This is not to be confused with the International Unit (IU), which is an unrelated measure of other biologically active substances such as vitamin D.

Because transglucosidase is an enzyme, the dosages are measured in “units of enzyme activity” not milligrams or International Units (IU). A 450,000 unit dose is typically the amount found in one capsule.

Summary

Chronically elevated glucose and insulin levels, especially those immediately following a meal, should be a major concern of any adult—even if you have no known history of high blood sugar. High insulin and glucose blood levels are at least as dangerous as high cholesterol when it comes to increased risk of cardiovascular disease.

In addition, chronically elevated glucose and insulin sharply elevate cancer rates. That’s why it’s important to take all possible steps to prevent dietary starch from converting into deadly sugar calories.

Transglucosidase is a groundbreaking supplement that is the first of its kind. Its dual mechanism of action helps manage high blood sugar and excess insulin by blocking the release of harmful sugar from starch…converting it instead into beneficial fiber.

This is a medical breakthrough capable of mitigating the growing diabetes epidemic—and is a critical new tool in our kit for managing dangerous metabolic conditions.

If your fasting glucose is over 85 mg/dL (which most adults are), or you have other indicators of glucose impairment such as elevated hemoglobin A1c or elevated fasting insulin, take transglucosidase before your two heaviest starch-containing meals of the day.

Human clinical trials have established its value in healthy as well as diabetic individuals. And that translates to lower risks for cancer, vision problems, and heart disease.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.

Doggie Diabetes
Doggie Diabetes

Diabetes is common in dogs as well as people. Fortunately, transglucosidase can help manage glucose levels in dogs as well as in humans. When researchers in Japan studied transglucosidase in animals, they found that the results were virtually identical with what we’ve seen in human studies.21

Healthy non-diabetic control dogs receiving transglucosidase experienced lower total after-meal glucose and insulin levels compared with those receiving the control diet alone. And the usual “spike” in after-meal glucose levels was virtually eliminated, allowing the dogs to maintain normal glucose concentrations of 85 to 95 mg/dL.21

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