Life Extension Blood Test Super Sale

Life Extension Magazine

Life Extension Magazine November 2013
Report  

Novel Method to Mitigate Lactose Intolerance

By William Lancaster

Summary

Lactose intolerance is one of the most common forms of food intolerance, afflicting upwards of 50 million people in America alone with gas, bloating, cramping, and diarrhea. Its cause is often an age-related loss—frequently beginning before age five26—of the enzyme lactase that’s required for breaking down the unique milk sugar, lactose.

Many sufferers simply avoid milk products.

Another option is replacing the lactase enzyme, but current lactase formulations work only in the acidic environment of the stomach. That limits their usefulness to the 15-45 minutes that a load of lactose remains in the stomach. A substantial amount of undigested lactose, therefore, still reaches the intestinal tract to cause symptoms.

A superior form of the lactase enzyme, neutral lactase, works in the small intestine instead, allowing it to continue breaking down lactose for up to 4 hours! Neutral lactase is packaged in a unique, acid-resistant form that allows it to pass through the stomach rapidly, and reach the small intestine intact.

Treatment with neutral lactase has been shown to reduce symptoms of lactose intolerance more effectively than treatment with standard, acid lactase supplements.

If you suffer from lactose intolerance, you owe it to yourself to use neutral lactase as a means of reducing—or even eliminating—your symptoms.

FIGURE 5: Greater Lactose-Digesting Capacity of Neutral Lactase
FIGURE 5: Greater Lactose-Digesting Capacity of Neutral Lactase

Standard acid lactase (red) can act only in the acid environment of the stomach. But gastrointestinal contents are present in the stomach for only a relatively short period. Neutral lactase (blue) acts in the neutral pH of the small intestine, where digesting food remains for up to 4 hours. This allows neutral lactase to break down substantially more lactose than acid lactase. The size of this effect is shown in grams on the vertical axis, while the horizontal axis indicates time.4

 

Warning

If one suffers lactose intolerance and can avoid milk in their diet, they may be better off than taking a product like neutral lactase. The reason is that most people already have excess amounts of glucose in their bloodstream. A lactose intolerant individual who starts consuming milk products because they take neutral lactase may be unwittingly spiking after-meal glucose blood levels, which increases risk of every disease and may accelerate aging.

While lactose intolerance is associated with loss of bone mass, this problem can be solved by supplementing with calcium, magnesium, vitamins D and K2, along with nutrients one would find in their multi-vitamin/mineral formula.

The only bone mineral not commonly found in supplements is phosphorous. A typical adult needs about 700 mg a day. Those who eat meat (or lots of whole grain cereals and breads) should be assured of adequate phosphorous. Those who avoid dairy, meat, and even grains should consider a 500 mg a day phosphorous supplement to ensure they get enough of this critical component of bone. Please know that most people get enough phosphorous from their diet and don’t need to supplement with any more.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.

References

  1. Obermayer-Pietsch BM, Gugatschka M, Reitter S, et al. Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption? Osteoporos Int. 2007 Apr;18(4):445-51. Epub 2006 Nov 14.
  2. Savaiano D. Lactose intolerance: an unnecessary risk for low bone density. Nestle Nutr Workshop Ser Pediatr Program. 2011;67:161-71.
  3. Fraissl L, Leitner R, Missbichler A. Novel formulation of neutral lactase improves digestion of dairy products in case of lactose intolerance. Clinical and Translational Allergy. 2011 August 12;1(Suppl 1):104.
  4. SCIOTEC Diagnostic Technologies GmbH. Scientific Information on lactose intolerance and Lactosolv Tulln an der Donau, Austria 2012.
  5. Bayless TM, Rothfeld B, Massa C, Wise L, Paige D, Bedine MS. Lactose and milk intolerance: clinical implications. N Engl J Med. 1975 May 29;292(22):1156-9.
  6. Available at: http://emedicine.medscape.com/article/187249-overview#showall. Accessed June 18, 2012.
  7. Beja-Pereira A, Luikart G, England PR, et al. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet. 2003 Dec;35(4):311-3.
  8. Di Stefano M, Veneto G, Malservisi S, et al. Lactose malabsorption and intolerance and peak bone mass. Gastroenterology. 2002 Jun;122(7):1793-9.
  9. Kudlacek S, Freudenthaler O, Weissboeck H, Schneider B, Willvonseder R. Lactose intolerance: a risk factor for reduced bone mineral density and vertebral fractures? J Gastroenterol. 2002;37(12):1014-9.
  10. Lomer MC, Parkes GC, Sanderson JD. Review article: lactose intolerance in clinical practice--myths and realities. Aliment Pharmacol Ther. 2008 Jan 15;27(2):93-103.
  11. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med. 1995 Jul 6;333(1):1-4.
  12. Sieber R, Stransky M, de Vrese M. Lactose intolerance and consumption of milk and milk products. Z Ernahrungswiss. 1997 Dec;36(4):375-93.
  13. Montalto M, Curigliano V, Santoro L, et al. Management and treatment of lactose malabsorption. World J Gastroenterol. 2006 Jan 14;12(2):187-91.
  14. Vonk RJ, Priebe MG, Koetse HA, et al. Lactose intolerance: analysis of underlying factors. Eur J Clin Invest. 2003 Jan;33(1):70-5.
  15. Beyerlein L, Pohl D, Delco F, Stutz B, Fried M, Tutuian R. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther. 2008 Apr;27(8):659-65.
  16. Uchida N, Sakamoto O, Irie M, et al. Two novel mutations in the lactase gene in a Japanese infant with congenital lactase deficiency. Tohoku J Exp Med. 2012;227(1):69-72.
  17. Hermans MM, Brummer RJ, Ruijgers AM, Stockbrugger RW. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol. 1997 Jun;92(6):981-4.
  18. Rosado JL, Solomons NW, Lisker R, Bourges H. Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime. Gastroenterology. 1984 Nov;87(5):1072-82.
  19. Garcia-Garibay M, Gomez-Ruiz L. Uses of microbial beta-galactosidases to reduce lactose content in milk and dairy products. Rev Invest Clin. 1996 Nov;48 Suppl:51-61.
  20. Tello-Solis SR, Jimenez-Guzman J, Sarabia-Leos C, et al. Determination of the secondary structure of Kluyveromyces lactis beta-galactosidase by circular dichroism and its structure-activity relationship as a function of the pH. J Agric Food Chem. 2005 Dec 28;53(26):10200-4.
  21. Solomons NW, Guerrero AM, Torun B. Effective in vivo hydrolysis of milk lactose by beta-galactosidases in the presence of solid foods. Am J Clin Nutr. 1985 Feb;41(2):222-7.
  22. Montalto M, Nucera G, Santoro L, et al. Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr. 2005 Apr;59(4):489-93.
  23. Solomons NW, Guerrero AM, Torun B. Dietary manipulation of postprandial colonic lactose fermentation: II. Addition of exogenous, microbial beta-galactosidases at mealtime. Am J Clin Nutr. 1985 Feb;41(2):209-21.
  24. Coenen TM, Bertens AM, de Hoog SC, Verspeek-Rip CM. Safety evaluation of a lactase enzyme preparation derived from Kluyveromyces lactis. Food Chem Toxicol. 2000 Aug;38(8):671-7.
  25. Pereira-Rodriguez A, Fernandez-Leiro R, Gonzalez-Siso MI, Cerdan ME, Becerra M, Sanz-Aparicio J. Structural basis of specificity in tetrameric Kluyveromyces lactis beta-galactosidase. J Struct Biol. 2012 Feb;177(2):392-401.
  26. Wang Y, Harvey CB, Hollox EJ, et al. The genetically programmed down-regulation of lactase in children. Gastroenterology. 1998 Jun;114(6):1230-6.
  27. Bahna SL. Cow’s milk allergy versus cow milk intolerance. Ann Allergy Asthma Immunol. 2002 Dec;89(6 Suppl 1):56-60.