By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Diet and Nutrition have been published. According to news reporting originating from Cairo, Egypt, by NewsRx correspondents, research stated, "This study investigated the potential role of folate in the dimethylhydrazine (DMH) colon cancer model in male Wistar rats. For induction of colon cancer, group 1 rats were injected subcutaneously with 30 mg DMH/kg body weight weekly for 30 wk."
Our news editors obtained a quote from the research from the University of Cairo, "Group 2 received DMH vehicle. Group 3 rats received DMH as in Group 1 but their diet was supplemented with 8 mg folate/kg diet. Group 4 was fed diet supplemented with 8 mg folate/kg diet. Upregulation of DNA damage repair genes Apurinic/apyrimidinic endonuclease 1, X-ray repair complementing defective repair in Chinese hamster cells 5, 8-oxoguanine-DNA glycosylase, and proliferating cell nuclear antigen, associated with a reduction of folic acid level was observed in colons of DMH group. Reductions of these gene upregulations and a significant increase of colonic folic acid level occurred in the DMH group supplemented with folic acid and this group also had significant inhibition of tumor incidence, normal survival rate and histologically nearly normal colonic architecture."
According to the news editors, the research concluded: "It can be concluded that folate supplementation exerts a potent protective effect on rat colon carcinogenesis via significant modulation of DNA repair, providing a mechanism by which it plays a role in the etiology of human cancer."
For more information on this research see: Dietary folate suppresses DMH-induced colon carcinogenesis in a rat model and affects DMH-induced expression of four DNA repair enzymes. Nutrition and Cancer, 2012;64(8):1196-203 (see also Diet and Nutrition).
The news editors report that additional information may be obtained by contacting N.A. Sadik, Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Keywords for this news article include: Cairo, Egypt, Africa, DNA Repair, Proteomics, DNA Research, Diet and Nutrition, Deoxyribonucleic Acid.
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