By a News Reporter-Staff News Editor at Gastroenterology Week -- Research findings on Diabetes are discussed in a new report. According to news reporting out of Raritan, New Jersey, by NewsRx editors, research stated, "Diabetes is a debilitating disease characterized by a chronic inability to normalize blood glucose levels. Transplanting cadaveric pancreata or isolated pancreatic islets can restore glucose homeostasis, but organ demand outstrips supply."
Our news journalists obtained a quote from the research, "Consequently, there is significant interest in alternative tissue sources. This review summarizes state-of-the-art efforts to generate scalable, functional beta-cells to treat diabetes. Applying knowledge gleaned from developmental biology, human pluripotent stem cells can be treated stepwise with combinations of small molecules, developmentally relevant growth factors, and morphogens to generate pancreatic progenitor cells (PPCs) in vitro. Transplanted PPCs can then further mature in vivo into functional islet-like tissues containing all of the endocrine hormone cells present in adult islets and can reverse hyperglycemia in a diabetic animal model. Recent publications demonstrate that skin, liver, and other cell lineages may also be reprogrammed to functional beta-like cells. Although generation of fully functional beta cells in vitro has not yet been achieved, possible intermediate approaches to treat diabetes include using PPCs or reprogramming adult cells to b-like cells. A cell therapy with either approach will require isolation from the host immune response."
According to the news editors, the research concluded: "Ongoing efforts are addressing this need through the use of immune-isolation devices to avoid immunosuppressive drugs."
For more information on this research see: Generating beta-cells in vitro: progress towards a Holy Grail. Current Opinion in Endocrinology Diabetes and Obesity, 2013;20(2):112-117. Current Opinion in Endocrinology Diabetes and Obesity can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Diabetes).
Our news journalists report that additional information may be obtained by contacting B.H. Fryer, Janssen Res & Dev LLC, Raritan, NJ 08869, United States.
Keywords for this news article include: Raritan, Diabetes, New Jersey, United States, North and Central America
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