By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on Lung Cancer. According to news reporting out of Fukuoka, Japan, by NewsRx editors, research stated, "Recently, we reported on the existence of activated protein kinase C alpha (PKC alpha) in blood and the possibility for its use in cancer diagnosis. In the present study, serum samples collected from patients with different lung cancer types (small-cell cancer, adenocarcinoma, and anaplastic cancer) were phosphorylated with a PKC alpha-specific peptide substrate and the phosphorylation ratio was detected by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
Our news journalists obtained a quote from the research, "When 13 patient serum samples were phosphorylated with peptide substrates, phosphorylated peaks were obtained in eight samples. However, no peak associated with the phosphorylated peptide was observed using serum samples obtained from 10 healthy persons. Moreover, broadly used cancer biomarkers (progastrin-releasing peptide, carcinoembryonic antigen, and cytokeratin-19 fragment) were identified in eight samples among the 13 samples studied."
According to the news editors, the research concluded: "These results suggest that serum activated PKC alpha is a reliable biomarker, applicable to lung cancer diagnosis."
For more information on this research see: Kinase Activity of Protein Kinase C alpha in Serum as a Diagnostic Biomarker of Human Lung Cancer. Anticancer Research, 2013;33(2):485-488. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research - www.iiar-anticancer.org/; Anticancer Research - www.iiar-anticancer.org/main.php?id=2)
Our news journalists report that additional information may be obtained by contacting J.H. Kang, Int Res Center Mol Syst, Fukuoka, Japan (see also Lung Cancer).
Keywords for this news article include: Asia, Japan, Blood, Serum, Fukuoka, Oncology, Peptides, Immunology, Proteomics, Lung Cancer, Lung Neoplasms, Enzymes and Coenzymes, Protein Kinase C-alpha, Phosphotransferases (Alcohol Group Acceptor)
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