By a News Reporter-Staff News Editor at Stem Cell Week -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, "The squamous epithelium covering the skin and oral mucosa relies on epithelial stem cells for tissue renewal. Dynamic changes in DNA methylation, histone methylation and acetylation, and higher order chromatin structure are required to preserve their self-renewal capacity while orchestrating the timely execution of cell differentiation programs."
The news correspondents obtained a quote from the research from the National Institutes of Health, "This complex network of epigenetic modifications shapes the epithelial stem cell identity and fate. Pathological alterations can be perceived by aberrant chromatin sensors, such as the INK4/ARF locus, which initiate tumor suppressive cell senescence programs, and can often result in epithelial stem cell exhaustion."
According to the news reporters, the research concluded: "Unveiling the mechanisms controlling the epigenome in epithelial stem cells may help protect against the loss of their tissue regenerative capacity, thereby preventing premature aging without increasing cancer risk."
For more information on this research see: Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity. Current Opinion In Cell Biology, 2013;25(2):162-9. (Elsevier - www.elsevier.com; Current Opinion In Cell Biology - www.elsevier.com/wps/product/cws_home/601296)
Our news journalists report that additional information may be obtained by contacting R. Iglesias-Bartolome, Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, United States (see also Stem Cell Research).
Keywords for this news article include: Bethesda, Maryland, United States, Stem Cell Research, North and Central America.
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