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Daily News: Aging

Researchers at University of North Texas Report Findings in Alzheimer Disease


NewsRx.com

05-17-13

By a News Reporter-Staff News Editor at Cardiovascular Week -- Fresh data on Neurodegenerative Diseases are presented in a new report. According to news reporting out of Fort Worth, Texas, by NewsRx editors, research stated, "Numerous serum and plasma based biomarkers of systemic inflammation have been linked to both neuropsychiatric disorders and Alzheimer's disease (AD). The present study investigated the relationship of clinical biomarkers of cardiovascular risk (cholesterol, triglycerides, and homocysteine) and a panel of markers of systemic inflammation (CRP, TNF-a, IL1-ra, IL-7, IL-10, IL-15, IL-18) and microvascular pathology (ICAM-1, VCAM-1) to neuropsychiatric symptoms in a sample with mild AD."

Our news journalists obtained a quote from the research from the University of North Texas, "Biomarker data was analyzed on a sample of 194 diagnosed with mild to moderate probable AD. The sample was composed of 127 females and 67 males. The presence of neuropsychiatric symptoms was gathered from interview with caretakers/family members using the Neuropsychiatric Inventory. For the total sample, IL-15, VCAM (vascular adhesion molecule), and triglycerides were significantly and negatively related to number of neuropsychiatric symptoms, and total cholesterol and homocysteine were positively related and as a group accounted for 16.1% of the variance. When stratified by gender, different patterns of significant biomarkers were found with relationships more robust for males for both total symptoms and symptom clusters. A combination of biomarkers of systemic inflammation, microvascular pathology, and clinical biomarkers of cardiovascular risk can account for a significant portion of the variance in the occurrence of neuropsychiatric symptoms in AD supporting a vascular and inflammatory component of psychiatric disorders found in AD."

According to the news editors, the research concluded: "Gender differences suggest distinct impact of specific risks with total cholesterol, a measure of cardiovascular risk, being the strongest marker for males and IL-15, a marker of inflammation, being the strongest for females."

For more information on this research see: Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer's disease. Journal of Alzheimer's Disease, 2013;35(2):363-71. Journal of Alzheimer's Disease can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands (see also Neurodegenerative Diseases).

Our news journalists report that additional information may be obtained by contacting J.R. Hall, Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX USA. Dept. of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, United States.

Publisher contact information for the Journal of Alzheimer's Disease is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.

Keywords for this news article include: Texas, Dementia, Pathology, Fort Worth, Cardiology, Tauopathies, Inflammation, United States, Brain Diseases, Cardiovascular, Alzheimer Disease, North and Central America, Neurodegenerative Diseases, Central Nervous System Diseases.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2013, Cardiovascular Week via NewsRx.com

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