By a News Reporter-Staff News Editor at Obesity & Diabetes Week -- Fresh data on Peptide Proteins are presented in a new report. According to news reporting originating from Warsaw, Poland, by NewsRx correspondents, research stated, "The physiological mechanisms that promote longevity remain unclear. It has been suggested that insulin sensitivity is preserved in centenarians, whereas typical aging is accompanied by increasing insulin resistance."
Our news editors obtained a quote from the research, "The oldest-old individuals display raised total adiponectin levels, despite the potential correlation between enhanced adiponectin and all-cause and cardiovascular mortality. To evaluate the level of adiponectin and its isoforms in sera of centenarians and to assess associations between adiponectin and metabolic parameters. A group of 58 Polish centenarians (50 women and 8 men, mean age 101 +/- 1.34 years) and 68 elderly persons (55 women and 13 men, mean age 70 +/- 5.69 years) as controls. Serum samples were analyzed to evaluate the following parameters: adiponectin array (total adiponectin, HWM-, MMW- and LMW-adiponectin; all by ELISA methods), insulin (by IRMA methods), glucose and lipid profiles. HOMA-IR was calculated. Clinical data were collected. Statistical analyses were performed. The concentrations of all adiponectin isoforms were significantly higher in the oldest-old participants. In the centenarian group, total adiponectin positively correlated with age and HDL-cholesterol, and HMW-adiponectin was negatively associated with insulin and triglycerides. The long-lived participants had a lower incidence of hypertension, type 2 diabetes, overweight and obesity, with lower concentrations of serumglucose and insulin, and reduced HOMA-IR. Our findings support the thesis that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in comparison with elderly individuals."
According to the news editors, the research concluded: "However, additional work is necessary to understand the relevance of these findings to longevity."
For more information on this research see: Assessment of adiponectin and its isoforms in Polish centenarians. Experimental Gerontology, 2013;48(4):401-407. Experimental Gerontology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Experimental Gerontology - www.elsevier.com/wps/product/cws_home/525468)
The news editors report that additional information may be obtained by contacting W. Bik, Medical Center Postgraduate Educ, Dept. of Clin Physiol, PL-01813 Warsaw, Poland (see also Peptide Proteins).
Keywords for this news article include: Warsaw, Poland, Europe, Adipokines, Proinsulin, Adiponectin, Peptide Hormones, Peptide Proteins
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