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Studies from University Medical Center Provide New Data on Prostate Cancer


NewsRx.com

06-14-13

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Prostate Cancer are presented in a new report. According to news reporting from Hamburg, Germany, by NewsRx journalists, research stated, "Neuron-glia-related cell-adhesion molecule (Nr-CAM) is another potential membrane-bound target molecule for specific prostate cancer therapy. The role of Nr-CAM in normal and neoplastic prostate tissue has not been extensively studied."

The news correspondents obtained a quote from the research from University Medical Center, "The aim of our study is to evaluate the prevalence of Nr-CAM expression in prostate cancer and to explore its association with phenotype and clinical disease course. A preexisting tissue microarray including more than 3000 prostate cancers that underwent prostatectomy at our center with clinical follow-up data was used. The tissue microarray (TMA) was immunhistochemically stained for Nr-CAM. A total of 2883 (88.4%) of tumor samples were interpretable in our TMA analysis. Membranous Nr-CAM staining was seen in 1418 (49.2%) of 2883 analyzable cases. According to predefined criteria, staining was considered weak in 778 (27.0%), moderate in 412 (14.3%) and strong in 228 (7.9%) cancers. Significant associations were found with pathological tumor stage (p=0.0015), Gleason grade (p=0.0003), nodal stage (p=0.0061), preoperative PSA (p=0.0138) and prolonged PSA recurrence-free survival (p <0.0001). Nr-CAM expression is frequent in prostate cancer. High level of Nr-CAM expression is associated with favorable tumor phenotype and reduced risk of PSA recurrence."

According to the news reporters, the research concluded: "The abundant presence of Nr-CAM in prostate cancer epithelium makes Nr-CAM a potential target of therapy."

For more information on this research see: High Nr-CAM expression is associated with favorable phenotype and late PSA recurrence in prostate cancer treated by prostatectomy. Prostate Cancer and Prostatic Diseases, 2013;16(2):159-64. (Nature Publishing Group - www.nature.com/; Prostate Cancer and Prostatic Diseases - www.nature.com/pcan/)

Our news journalists report that additional information may be obtained by contacting M.C. Tsourlakis, Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (see also Prostate Cancer).

Keywords for this news article include: Europe, Hamburg, Germany, Therapy, Oncology, Prostate Cancer, Prostatic Neoplasms.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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