By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Diet and Nutrition. According to news reporting originating from Arhus, Denmark, by NewsRx correspondents, research stated, "Obesity is associated with a markedly increased risk of nonalcoholic fatty liver disease. The anti-inflammatory polyphenol resveratrol possess promising properties in preventing this metabolic condition by dampening the pathological inflammatory reaction in the hepatic tissue."
Our news editors obtained a quote from the research from Aarhus University Hospital, "However, in the current study, we hypothesize that the beneficial effect of resveratrol is not solely attributable to its anti-inflammatory potential. Eight-week-old male Wistar rats were randomly distributed into 3 groups of 12 animals each: control diet (C), high-fat diet (HF), and HF supplemented with 100 mg resveratrol daily (HFR). After 8 weeks of dietary treatment, the rats were euthanized and relevant tissues were prepared for subsequent analysis. Resveratrol prevented the high fat-induced steatosis assessed by semiquantitative grading, which furthermore corresponded with a complete normalization of the hepatic triglyceride content (p <.001), despite no change in total body fat. In HFR, the hepatic uncoupling protein 2 expression was significantly increased by 76% and 298% as compared with HF and C, respectively. Moreover, the hepatic mitochondria content in HFR was significantly higher as compared with both C and HF (p <.001 and p=.004, respectively). We found no signs of hepatic inflammation, hereby demonstrating that resveratrol protects against fatty liver disease independently of its proposed anti-inflammatory potential."
According to the news editors, the research concluded: "Our data might indicate that an increased number of mitochondria and, particularly, an increase in hepatic uncoupling protein 2 expression are involved in normalizing the hepatic fat content due to resveratrol supplementation in rodents fed a high-fat diet."
For more information on this research see: Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet. Nutrition Research, 2012;32(9):701-8. (Elsevier - www.elsevier.com; Nutrition Research - www.elsevier.com/wps/product/cws_home/525483)
The news editors report that additional information may be obtained by contacting M.M. Poulsen, Dept. of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Arhus C, Denmark (see also Diet and Nutrition).
Keywords for this news article include: Arhus, Europe, Denmark, Diet and Nutrition, Fatty Liver Disease, Digestive System Diseases.
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