By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Prostate Cancer. According to news originating from Jeonju, South Korea, by NewsRx correspondents, research stated, "Histone deacetylase (HDAC) inhibitors are emerging as potent anticancer agents due to their ability to induce apoptosis in various cancer cells, including prostate cancer cells. In the present study, we synthesized a novel HDAC inhibitor, A248, and investigated its apoptotic activity and molecular target in the DU145 and PC3 human prostate cancer cell lines."
Our news journalists obtained a quote from the research from Chonbuk National University, "A248 inhibited the growth of DU145 and PC3 cells and induced apoptosis, as demonstrated by nuclear fragmentation and the accumulation of cells at subG1 phase of cell cycle. The treatment of DU145 and PC3 prostate cancer cells with A248 resulted in the downregulation of specificity protein 1 (Sp1) expression. Since the expression levels of survivin and Mcl-1 depend on Sp1, we also investigated the effects of A248 on survivin and Mcl-1 expression using western blot analysis and immunocytochemistry. The results showed that A248 markedly decreased the expression of survivin and Mcl-1."
According to the news editors, the research concluded: "These data suggest that A248 has apoptotic activity in human prostate cancer cells and that Sp1 may be the molecular target of A248 treatment for inducing apoptosis in prostate cancer cells."
For more information on this research see: A248, a novel synthetic HDAC inhibitor, induces apoptosis through the inhibition of specificity protein 1 and its downstream proteins in human prostate cancer cells. Molecular Medicine Reports, 2013;8(1):195-200 (see also Prostate Cancer).
The news correspondents report that additional information may be obtained from E.S. Choi, Dept. of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University, Jeonju 561-756, South Korea.
Keywords for this news article include: Asia, Jeonju, Oncology, Peptides, Proteins, Apoptosis, Treatment, South Korea, Amino Acids, Prostate Cancer, Cancer Gene Therapy, Prostatic Neoplasms.
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