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Studies from Catholic University of Korea Have Provided New Information about Fatty Liver



By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Liver Diseases and Conditions have been published. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, "Recent studies suggest an association of vitamin D with obesity, diabetes and cardiovascular diseases. We analyzed the association of serum vitamin D level assessed by 25-hydroxyvitamin D-3 {25(OH)D-3} with nonalcoholic fatty liver disease (NAFLD) in apparently healthy men."

Our news journalists obtained a quote from the research from the Catholic University of Korea, "We performed a cross-sectional study of 6,567 Korean men who participated in a health screening program, evaluating the association of serum 25(OH)D-3 levels with the risk of NAFLD assessed by abdominal ultrasonogram. Of the participants, 43.6% had NAFLD and 21.1% had metabolic syndrome. Age, serum calcium, and aspartate aminotransferase levels showed weak but significant positive correlations with 25(OH)D-3 level; total cholesterol, triglycerides, low-density lipoprotein cholesterol and fasting insulin level showed weak but significant negative correlations with 25(OH)D-3 level. The mean 25(OH)D-3 level was significantly lower in participants with NAFLD than in those without (38.7 +/- 9.0 vs. 39.7 +/- 9.7 nmol/L, p< 0.001). When participants were divided into tertiles based on mean 25(OH)D-3 level, the proportion with NAFLD significantly increased as mean 25(OH)D-3 level decreased (40.0, 45.0 and 45.9%, p for linear trend < 0.001). Multiple logistic regression analyses with NAFLD as the dependent variable showed that the tertiles with lower 25(OH)D-3 levels had a significantly increased risk for NAFLD compared with the highest tertile, even after adjusting for body mass index and metabolic syndrome (OR 1.247 and 1.408 vs. the highest tertile, p< 0.001)."

According to the news editors, the research concluded: "Thus, participants with higher serum 25(OH)D-3 showed a significantly reduced risk for NAFLD compared with the low 25(OH)D-3 groups, independent of obesity and metabolic syndrome."

For more information on this research see: High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome. Endocrine Journal, 2013;60(6):743-752. Endocrine Journal can be contacted at: Japan Endocrine Soc, 75 Yanaginobanba Nishiiru-Masuya-Cho, Sanjou-Dori, Nakagyou-Ku, Kyoto, 604-8111, Japan (see also Liver Diseases and Conditions).

Our news journalists report that additional information may be obtained by contacting E.J. Rhee, Catholic University of Korea, Dept. of Endocrinol & Metab, Seoul, South Korea. Additional authors for this research include M.K. Kim, S.E. Park, C.Y. Park, K.H. Baek, W.Y. Lee, M.I. Kang, S.W. Park, S.W. Kim and K.W. Oh.

Keywords for this news article include: Asia, Seoul, Healthcare, South Korea, Metabolic Syndrome, Fatty Liver Disease, Digestive System Diseases, Liver Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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