Whole Body Health Sale

Study Results from University of Colorado Update Understanding of Putrescine



By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Putrescine is the subject of a report. According to news reporting originating from Boulder, Colorado, by NewsRx correspondents, research stated, "Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, would improve arterial aging."

Our news editors obtained a quote from the research from the University of Colorado, "Aortic pulse wave velocity (aPWV), a measure of arterial stiffness, was similar to 20% greater in old (0, 28 months) compared with young C57BL6 mice (Y, 4 months, P< 0.05). Arterial endothelium-dependent dilation (EDD), a measure of endothelial function, was similar to 25% lower in 0 (P < 0.05 vs. Y) due to reduced nitric oxide (NO) bioavailability. These impairments were associated with greater arterial oxidative stress (nitrotyrosine), superoxide production, and protein cross-linking (advanced glycation end-products, AGEs) in O (all P< 0.05). Spermidine supplementation normalized aPWV, restored NO-mediated EDD and reduced nitrotyrosine, superoxide, AGEs and collagen in O. These effects of spermidine were associated with enhanced arterial expression of autophagy markers, and in vitro experiments demonstrated that vascular protection by spermidine was autophagy-dependent. Our results indicate that spermidine exerts a potent anti-aging influence on arteries by increasing NO bioavailability, reducing oxidative stress, modifying structural factors and enhancing autophagy."

According to the news editors, the research concluded: "Spermidine may be a promising nutraceutical treatment for arterial aging and prevention of age-associated CVD."

For more information on this research see: The autophagy enhancer spermidine reverses arterial aging. Mechanisms of Ageing and Development, 2013;134(7-8):314-320. Mechanisms of Ageing and Development can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Mechanisms of Ageing and Development - www.elsevier.com/wps/product/cws_home/506026)

The news editors report that additional information may be obtained by contacting T.J. LaRocca, University of Colorado, Dept. of Integrat Physiol, Boulder, CO 80309, United States. Additional authors for this research include R.A. Gioscia-Ryan, C.M. Hearon and D.R. Seals (see also Putrescine).

Keywords for this news article include: Boulder, Colorado, Polyamines, Putrescine, Spermidine, Nitric Oxide, United States, Biogenic Amines, Organic Chemicals, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2013, Cardiovascular Week via NewsRx.com

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

  • Consumer Alerts | Learn about issues that could impact your right to obtain the nutritional supplements and/or hormones such as DHEA that you depend on.

  • LEF Forum | Life Extension hosts Forums on Supplements, Hormones, Lifestyles, Disorders/Diseases, and other areas of interest to life extensionists worldwide.

  • What's Hot | News flashes are posted here frequently to keep you up-to-date with the latest advances in health care, nutritional supplements, and longevity.

  • Legislative Action Center | Take action on important current issues featured in Life Extension magazine and our web site.

  • Events | Find out about upcoming life extension related conferences, seminars, and meetings, or view reports on past events.

  • Life Extension Update | Our periodical newsletter reports new findings in longevity, preventive medicine and disease as soon as they are discovered!

  • Multimedia Center | An information-packed collection of video and audio featuring various health topics of importance to you.

Get Your FREE Nutritional Supplement Guide
Related Forum Topics