By a News Reporter-Staff News Editor at Blood Weekly -- Fresh data on Neurodegenerative Diseases are presented in a new report. According to news reporting from London, United Kingdom, by NewsRx journalists, research stated, "Markers of Alzheimer's disease (AD) are being widely sought with a number of studies suggesting blood measures of inflammatory proteins as putative biomarkers. Here we report findings from a panel of 27 cytokines and related proteins in over 350 subjects with AD, subjects with Mild Cognitive Impairment (MCI) and elderly normal controls where we also have measures of longitudinal change in cognition and baseline neuroimaging measures of atrophy."
The news correspondents obtained a quote from the research from Institute for Health, "In this study, we identify five inflammatory proteins associated with evidence of atrophy on MR imaging data particularly in whole brain, ventricular and entorhinal cortex measures. In addition, we observed six analytes that showed significant change (over a period of one year) in people with fast cognitive decline compared to those with intermediate and slow decline. One of these (IL-10) was also associated with brain atrophy in AD."
According to the news reporters, the research concluded: "IL-10 was associated with both clinical and imaging evidence of severity of disease and might therefore have potential to act as biomarker of disease progression."
For more information on this research see: Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. Plos One, 2013;8(6):e64971. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting R. Leung, King's College London and National Institute for Health Research-NIHR, Biomedical Research Centres at South London and Maudsley NHS Foundation Trust and Guy's and St Thomas' NHS Foundation Trust, London, UK. Additional authors for this research include P. Proitsi, A. Simmons, K. Lunnon, A. Guntert, D. Kronenberg, M. Pritchard, M. Tsolaki, P. Mecocci, I. Kloszewska, B. Vellas, H. Soininen, L.O. Wahlund and S. Lovestone (see also Neurodegenerative Diseases).
Keywords for this news article include: London, Europe, Dementia, Peptides, Proteins, Amino Acids, Tauopathies, United Kingdom, Brain Diseases, Alzheimer Disease, Neurodegenerative Diseases, Central Nervous System Diseases.
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