By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Oncology are discussed in a new report. According to news originating from Qingdao, People's Republic of China, by NewsRx correspondents, research stated, "Aging is a major risk factor for prostate cancer (PCa), and prostatic stromal cells may also promote PCa progression. Accordingly, stromal cells do not equally promote PCa in older males and younger males."
Our news journalists obtained a quote from the research from the Department of Urology, "Therefore, it is also possible that the expression of androgen receptors (ARs) by prostatic stromal cells in older versus younger males plays different roles in PCa progression. Using a gene knockdown technique and coculture system, we found that the knockdown of the AR in prostatic stromal cells obtained from younger males could promote the invasiveness and metastasis of cocultured PC3/LNCaP cells in vitro. By contrast, the invasiveness and metastasis of LNCaP cells was inhibited when cocultured with prostatic stromal cells from older males that when AR expression was knocked down. Moreover, after targeting AR expression with small hairpinRNA(shRNA), matrix metalloproteinase (MMP) expression in stromal cells was observed to increase in the younger group, but decreased or remained unchanged in the older group. One exception, however, was observed with MMP9. In vivo, after knocking down AR expression in prostatic stromal cells, the incidence of metastatic lymph nodes was observed to increase in the younger age group, but decreased in the older age group. Together, these data suggest that the AR in prostatic stromal cells played opposite roles in PCa metastasis for older versus younger males."
According to the news editors, the research concluded: "Therefore, collectively, the function of the AR in prostatic stromal cells appears to change with age, and this may account for the increased incidence of PCa in older males."
For more information on this research see: Androgen receptors expressed by prostatic stromal cells obtained from younger versus older males exhibit opposite roles in prostate cancer progression. Asian Journal of Andrology, 2013;15(5):672-678. Asian Journal of Andrology can be contacted at: Acta Pharmacologica Sinica, 294 Tai-Yuan Rd, Shanghai, 200031, Peoples R China. (Nature Publishing Group - www.nature.com/; Asian Journal of Andrology - www.nature.com/aja/)
The news correspondents report that additional information may be obtained from Y.Y. Lu, Qingdao Municipal Hosp, Dept. of Urol, Qingdao 266071, People's Republic of China. Additional authors for this research include B. Jiang, F.J. Zhao, D. Cui, Q. Jiang, J.J. Yu, E.H. Li, X.H. Wang, B.M. Han and S.J. Xia (see also Oncology).
Keywords for this news article include: Asia, Qingdao, Oncology, Stromal Cells, Prostate Cancer, Steroid Receptors, Androgen Receptors, Prostatic Neoplasms, DNA-Binding Proteins, Transcription Factors, Connective Tissue Cells, People's Republic of China
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