Whole Body Health Sale

Study Results from Uniformed Services University of the Health Sciences in the Area of Prostate Cancer Reported


NewsRx.com

10-25-13

By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Oncology. According to news reporting originating from Bethesda, Maryland, by NewsRx correspondents, research stated, "Mechanisms underlying progression to androgen-independent prostate cancer following radical ablation therapy remain poorly defined. Although intraprostatic infections have been highlighted as potential cofactors, pathogen influences on pathways that support tumor regrowth are not known."

Our news editors obtained a quote from the research from the Uniformed Services University of the Health Sciences, "To explore this provocative concept, we derived androgen-sensitive and -insensitive prostate epithelial cells persistently infected with human herpesvirus 8 (HHV-8), an oncogenic herpesvirus that has been detected in normal prostate epithelium, prostate adenocarcinoma, and biologic fluids of patients with prostate cancer, to explore its effects on transition to hormone-refractory disease. Strikingly, we found that HHV-8 infection of androgen-sensitive prostate cancer cells conferred the capacity for androgen-independent growth. This effect was associated with altered expression and transcriptional activity of the androgen receptor (AR). However, HHV-8 infection bypassed AR signaling by promoting enhancer of zeste homolog 2 (EZH2)-mediated epigenetic silencing of tumor-suppressor genes, including MSMB and DAB2IP that are often inactivated in advanced disease. Furthermore, we found that HHV-8 triggered epithelial-to-mesenchymal transition. Although HHV-8 has not been linked etiologically to prostate cancer, virologic outcomes revealed by our study provide mechanistic insight into how intraprostatic infections could constitute risk for progression to androgen-independent metastatic disease where EZH2 has been implicated."

According to the news editors, the research concluded: "Taken together, our findings prompt further evaluations of the relationship between HHV-8 infections and risk of advanced prostate cancer."

For more information on this research see: Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth. Cancer Research, 2013;73(18):5695-5708. Cancer Research can be contacted at: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA. (American Association for Cancer Research - www.aacr.com; Cancer Research - cancerres.aacrjournals.org/)

The news editors report that additional information may be obtained by contacting J.G. Mygatt, Uniformed Services University for Health Science, Dept. of Microbiol & Immunol, Emerging Infect Dis Program, Bethesda, MD 20814, United States. Additional authors for this research include A. Singhal, G. Sukumar, C.L. Dalgard and J.A.R. Kaleeba (see also Oncology).

Keywords for this news article include: Therapy, Bethesda, Maryland, Genetics, Hormones, Oncology, Virology, Herpes Virus, United States, Prostate Cancer, Prostatic Neoplasms, North and Central America, Androgens and Anabolic Steroids

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2013, Drug Week via NewsRx.com

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

  • Consumer Alerts | Learn about issues that could impact your right to obtain the nutritional supplements and/or hormones such as DHEA that you depend on.

  • LEF Forum | Life Extension hosts Forums on Supplements, Hormones, Lifestyles, Disorders/Diseases, and other areas of interest to life extensionists worldwide.

  • What's Hot | News flashes are posted here frequently to keep you up-to-date with the latest advances in health care, nutritional supplements, and longevity.

  • Legislative Action Center | Take action on important current issues featured in Life Extension magazine and our web site.

  • Events | Find out about upcoming life extension related conferences, seminars, and meetings, or view reports on past events.

  • Life Extension Update | Our periodical newsletter reports new findings in longevity, preventive medicine and disease as soon as they are discovered!

  • Multimedia Center | An information-packed collection of video and audio featuring various health topics of importance to you.

Top 12 Steps For Achieving Ultimate Health
Related Forum Topics