By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on Metabolic Bone Diseases have been published. According to news reporting originating from Perugia, Italy, by NewsRx correspondents, research stated, "Vascular calcification and osteoporosis share similar etiopatho-genetic mechanisms. Vitamin K2 deficiency could be responsible of the so called 'calcium paradox', that is the lack of calcium in the bone and its storage in the vessel wall."
Our news editors obtained a quote from the research, "These events may have clinically relevant consequences, such as cardiovascular accidents, and bone fractures. To review the biological function of vitamin K2 metabolism, the main factors related to its deficiency and the consequent clinical significance. Vitamin K2 is essential for the function of several proteins, involved in the maintenance of the normal structure of arterial wall, osteoarticular system, teeth, and for the regulation of cell growth. It has been demonstrated to have a pivotal role in the inhibition of vascular foci of calcification, and in the regulation of calcium deposition in the bone. Vitamin K2 deficiency is often subclinic in a large part of healthy population. This deficiency is related to the interaction of various factors, such as the reduced dietary intake, the alteration of intestinal absorption or production, with a possible role of intestinal microbiota and the increased consumption at the vessel wall. Vitamin K2 deficiency has recently been recognized as a protagonist in the development of vascular calcification and osteoporosis. Data reported so far are promising and, dietary supplementation seems a useful tool to contrast these diseases."
According to the news editors, the research concluded: "However, large studies or solid clinical correlations regarding vitamin K2 deficiency and its pathologic consequences are needed to confirm these preliminary experiences."
For more information on this research see: Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. European Review for Medical and Pharmacological Sciences, 2013;17(18):2433-2440. European Review for Medical and Pharmacological Sciences can be contacted at: Verduci Publisher, Via Gregorio Vii, Rome, 186-00165, Italy (see also Metabolic Bone Diseases).
The news editors report that additional information may be obtained by contacting R. Flore, Pizeta Pharma, Perugia, Italy. Additional authors for this research include F.R. Ponziani, T.A. Di Rienzo, M.A. Zocco, A. Flex, L. Gerardino, A. Lupascu, L. Santoro, A. Santoliquido, E. Di Stasio, E. Chierici, A. Lanti, P. Tondi and A. Gasbarrini.
Keywords for this news article include: Italy, Europe, Perugia, Genetics, Osteoporosis, Bone Research, Metabolic Bone Diseases
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