By a News Reporter-Staff News Editor at Angiogenesis Weekly -- New research on Diet and Nutrition is the subject of a report. According to news reporting originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "Regardless of their cell type of origin, all aggressive brain tumors, such as malignant gliomas and metastatic tumors produce brain edema, which is an important cause of patient morbidity and mortality. Caloric restriction (CR) has long been recognized as a natural therapy that improves health, promotes longevity, and significantly reduces both the incidence and growth of many tumor types."
Our news editors obtained a quote from the research from the Huazhong University of Science and Technology, "The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas. We found that CR significantly inhibited the intracerebral tumor growth, attenuated brain edema, and ultimately prolonged survival of mice with U87 gliomas. Plasma corticosterone level was found higher and serum VEGF and IGF-1 levels were found lower in CR, when compared to AL group. CR upregulated tight junction proteins including claudin-1, claudin-5 and ZO-1, downregulated VEGF and VEGFR2, enhanced ?-SMA expression, and reduced AQP1 expression in U87 gliomas. In addition, CR suppressed inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) formation in U87 gliomas."
According to the news editors, the research concluded: "CR attenuated edema in U87 orthotopic mouse glioma model associated with elevation of corticosterone, suppression of VEGF/VEGFR2, improvement of tight junctions, and suppression of iNOS expression and NO formation. Our results suggested that CR might be an effective therapy for recurrent malignant brain cancers through alleviating associated edema."
For more information on this research see: Caloric restriction reduces edema and prolongs survival in a mouse glioma model. Journal of Neuro-oncology, 2013;114(1):25-32. Journal of Neuro-oncology can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Neuro-oncology - www.springerlink.com/content/0167-594x/)
The news editors report that additional information may be obtained by contacting Y.S. Jiang, Center of Tumor, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Taiwan (see also Diet and Nutrition).
Publisher contact information for the Journal of Neuro-oncology is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, VEGF, Wuhan, Edema, Glioma, Therapy, Oncology, Chemicals, Chemistry, Nitric Oxide, Protein Kinases, Membrane Proteins, Diet and Nutrition, Angiogenic Proteins, Caloric Restriction, Phosphotransferases, Growth Factor Receptors, People's Republic of China, Receptor Protein Tyrosine Kinases.
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