By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Hormones is the subject of a report. According to news reporting originating in Aarhus, Denmark, by NewsRx journalists, research stated, "Vitamin D is associated with cardiovascular disease and renal function but the mechanisms are as yet unexplained. Microalbuminuria is associated with a higher risk of kidney function loss, cardiovascular disease, and mortality."
The news reporters obtained a quote from the research from Aarhus University, "Parathyroid hormone is a predictor of cardiovascular mortality and negatively correlated with glomerular filtration rate. We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH). A random sample of 6,784 individuals aged 30-60 years from a general population participated in the Inter99 study in 1999-2001. Vitamin D (serum-25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography. UACR and PTH were measured at baseline and follow-up. Increased UACR was defined as UACR > 4.0 mg/g reflecting the upper quartile at baseline. We included 4,330 individuals who participated at 5-year follow-up. In multivariable linear regression analysis, a 10-nmol/l higher baseline level of vitamin D was associated with a 5-year decrease in UACR by 0.92 % (95 % confidence interval, CI 0.13, 1.71). In multivariable logistic regression analysis, the odds ratio of developing increased UACR during follow-up was 0.96 (95 % CI 0.92, 0.98) per 10 nmol/l higher baseline vitamin D level. We found a significant inverse cross-sectional (p < 0.0001) but no prospective association (p = 0.6) between baseline vitamin D status and parathyroid hormone. We found low vitamin D status to be a predictor of long-term development of increased UACR."
According to the news reporters, the research concluded: "It remains to be proven whether vitamin D deficiency is a causal and reversible factor in the development of albuminuria."
For more information on this research see: Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population. Endocrine, 2013;44(2):473-480. Endocrine can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Endocrine - www.springerlink.com/content/1355-008x/)
Our news correspondents report that additional information may be obtained by contacting T. Skaaby, Aarhus University, Aarhus, Denmark. Additional authors for this research include L.L.N. Husemoen, C. Pisinger, T. Jorgensen, B.H. Thuesen, K. Rasmussen, M. Fenger, P. Rossing and A. Linneberg (see also Hormones).
Keywords for this news article include: Aarhus, Europe, Denmark, Cardiology, Cardiovascular, Peptide Hormones, Parathyroid Hormone
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