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Findings from Kobe University School of Medicine Has Provided New Information about Diabetes


By a News Reporter-Staff News Editor at Hematology Week -- Researchers detail new data in Diabetes. According to news reporting originating from Kobe, Japan, by NewsRx correspondents, research stated, "Vascular disease is one of the critical complications of diabetes. A growing body of evidence suggests that oxidative stress plays a key role for vascular disease progression."

Our news editors obtained a quote from the research from the Kobe University School of Medicine, "Recent studies have demonstrated a strong link between vitamin D and cardiovascular disease. We investigated the anti-oxidative effects of a vitamin D analog, 22-oxacalcitriol (maxacalcitol), on vascular lesions in type 2 diabetic rats. We used Spontaneously Diabetic Torii (SDT) rats, a model of non-obese type 2 diabetes. At 20 weeks of age, SDT rats were randomly divided into three groups: diabetes mellitus (DM, n), DM + maxacalcitol (DM + D, n), and DM + insulin (DM + I, n). The rats were sacrificed at 30 weeks for the evaluation of blood and urine samples as well as histopathology and mRNA expression in the aorta. Urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion and the number of 8-OHdG-positive cells were significantly lower in the DM + I and DM + D groups than in the DM group. Real-time polymerase chain reaction analysis demonstrated that NADPH p22 phox and NADPH p47 phox mRNA levels were markedly decreased in the DM + I and DM + D groups compared with the DM group. Furthermore, the mRNA expression of MCP-1, ICAM-1 and VCAM-1 was significantly reduced in the DM + I and DM + D groups compared with the DM group."

According to the news editors, the research concluded: "Our results suggest that the vasoprotective effects of vitamin D are mediated by reducing oxidative stress."

For more information on this research see: Anti-oxidative effect of vitamin D analog on incipient vascular lesion in non-obese type 2 diabetic rats. American Journal of Nephrology, 2013;37(2):167-74. (Karger -; American Journal of Nephrology -"3979)

The news editors report that additional information may be obtained by contacting K. Kono, Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan. Additional authors for this research include H. Fujii, K. Nakai, S. Goto, R. Kitazawa, S. Kitazawa, M. Shinohara, M. Hirata, M. Fukagawa and S. Nishi (see also Diabetes).

Keywords for this news article include: Kobe, Asia, Japan, Obesity, Diabetes, Bariatrics, Endocrinology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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