Life Extension Blood Test Super Sale

Daily News: Vitamins

Findings from Kobe University School of Medicine Has Provided New Information about Diabetes


NewsRx.com

11-15-13

By a News Reporter-Staff News Editor at Hematology Week -- Researchers detail new data in Diabetes. According to news reporting originating from Kobe, Japan, by NewsRx correspondents, research stated, "Vascular disease is one of the critical complications of diabetes. A growing body of evidence suggests that oxidative stress plays a key role for vascular disease progression."

Our news editors obtained a quote from the research from the Kobe University School of Medicine, "Recent studies have demonstrated a strong link between vitamin D and cardiovascular disease. We investigated the anti-oxidative effects of a vitamin D analog, 22-oxacalcitriol (maxacalcitol), on vascular lesions in type 2 diabetic rats. We used Spontaneously Diabetic Torii (SDT) rats, a model of non-obese type 2 diabetes. At 20 weeks of age, SDT rats were randomly divided into three groups: diabetes mellitus (DM, n), DM + maxacalcitol (DM + D, n), and DM + insulin (DM + I, n). The rats were sacrificed at 30 weeks for the evaluation of blood and urine samples as well as histopathology and mRNA expression in the aorta. Urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion and the number of 8-OHdG-positive cells were significantly lower in the DM + I and DM + D groups than in the DM group. Real-time polymerase chain reaction analysis demonstrated that NADPH p22 phox and NADPH p47 phox mRNA levels were markedly decreased in the DM + I and DM + D groups compared with the DM group. Furthermore, the mRNA expression of MCP-1, ICAM-1 and VCAM-1 was significantly reduced in the DM + I and DM + D groups compared with the DM group."

According to the news editors, the research concluded: "Our results suggest that the vasoprotective effects of vitamin D are mediated by reducing oxidative stress."

For more information on this research see: Anti-oxidative effect of vitamin D analog on incipient vascular lesion in non-obese type 2 diabetic rats. American Journal of Nephrology, 2013;37(2):167-74. (Karger - www.karger.com/; American Journal of Nephrology - content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr"3979)

The news editors report that additional information may be obtained by contacting K. Kono, Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan. Additional authors for this research include H. Fujii, K. Nakai, S. Goto, R. Kitazawa, S. Kitazawa, M. Shinohara, M. Hirata, M. Fukagawa and S. Nishi (see also Diabetes).

Keywords for this news article include: Kobe, Asia, Japan, Obesity, Diabetes, Bariatrics, Endocrinology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2013, Hematology Week via NewsRx.com

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

  • Consumer Alerts | Learn about issues that could impact your right to obtain the nutritional supplements and/or hormones such as DHEA that you depend on.

  • LEF Forum | Life Extension hosts Forums on Supplements, Hormones, Lifestyles, Disorders/Diseases, and other areas of interest to life extensionists worldwide.

  • What's Hot | News flashes are posted here frequently to keep you up-to-date with the latest advances in health care, nutritional supplements, and longevity.

  • Legislative Action Center | Take action on important current issues featured in Life Extension magazine and our web site.

  • Events | Find out about upcoming life extension related conferences, seminars, and meetings, or view reports on past events.

  • Life Extension Update | Our periodical newsletter reports new findings in longevity, preventive medicine and disease as soon as they are discovered!

  • Multimedia Center | An information-packed collection of video and audio featuring various health topics of importance to you.

Get Your FREE Nutritional Supplement Guide