By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Clinical Research. According to news reporting out of Santiago, Chile, by NewsRx editors, research stated, "This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation. Therapy to prevent post-operative atrial fibrillation remains suboptimal."
Our news journalists obtained a quote from the research from the University of Chile, "Although oxidative stress plays a key role in the pathogenesis of this arrhythmia, antioxidant reinforcement has produced controversial results. A total of 203 patients scheduled for on-pump cardiac surgery were randomized to placebo or supplementation with n-3 polyunsaturated fatty acids (2 g/day) (eicosapentaenoic acid: docosahexaenoic acid ratio 1: 2), vitamin C (1 g/day), and vitamin E (400 IU/day). The primary outcome was the occurrence of post-operative atrial fibrillation. Secondary outcomes were the biomarkers related to oxidative stress and inflammation. Post-operative atrial fibrillation occurred in 10 of 103 patients (9.7%) in the supplemented group versus 32 of 100 patients (32%) in the placebo group (p < 0.001). Early after surgery, placebo patients presented with increased levels of biomarkers of inflammation and oxidative stress, which were markedly attenuated by antioxidant supplementation. The activity of catalase, superoxide dismutase, and glutathione peroxidase in atrial tissue of the supplemented patients was 24.0%, 17.1%, and 19.7% higher than the respective placebo values (p < 0.05). The atrial tissue of patients who developed atrial fibrillation showed NADPH oxidase p47-phox subunit protein and mRNA expression 38.4% and 35.7% higher, respectively, than patients in sinus rhythm (p < 0.05)."
According to the news editors, the research concluded: "This safe, well-tolerated, and low-cost regimen, consisting of n-3 polyunsaturated fatty acids plus vitamins C and E supplementation, favorably affected post-operative atrial fibrillation, increased antioxidant potential, and attenuated oxidative stress and inflammation."
For more information on this research see: A Randomized Controlled Trial to Prevent Post-Operative Atrial Fibrillation by Antioxidant Reinforcement. Journal of the American College of Cardiology, 2013;62(16):1457-1465. Journal of the American College of Cardiology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA (see also Clinical Research).
Our news journalists report that additional information may be obtained by contacting R. Rodrigo, University of Chile, Fac Med, Pathophysiol Program, Inst Biomed Sci, Santiago 7, Chile. Additional authors for this research include P. Korantzopoulos, M. Cereceda, R. Asenjo, J. Zamorano, E. Villalabeitia, C. Baeza, R. Aguayo, R. Castillo, R. Carrasco and J.G. Gormaz.
Keywords for this news article include: Antioxidants, Chile, Surgery, Therapy, Santiago, Placebos, Inflammation, South America, Heart Disease, Clinical Research, Protective Agents, Atrial Fibrillation, Cardiac Arrhythmias, Clinical Trials and Studies
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