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New Crohn's Disease Study Findings Have Been Reported by Researchers at King Saud University


By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators discuss new findings in Inflammatory Bowel Diseases. According to news reporting originating from Riyadh, Saudi Arabia, by NewsRx editors, the research stated, "Oxygen free radical and lipid peroxides (oxidative stress) are highly reactive and represent very damaging compounds. Oxidative stress could be a major contributing factor to the tissue injury and fibrosis that characterize Crohn's disease."

Our news editors obtained a quote from the research from King Saud University, "An imbalance between increased reactive oxygen species levels and decreased antioxidant defenses occurs in Crohn's patients. Decreased blood levels of vitamins C and E and decreased intestinal mucosal levels of CuZn superoxide dismutase, glutathione, vitamin A, C, E, and beta-carotene have been reported for Crohn's patients. Increased levels of proinflammatory cytokines, such as interleukin-1 and -8 and tumor necrosis factor, have been detected in inflammatory bowel disease. Oxidative stress significantly increased the production of neutrophils, chemokines, and interleukin-8. These effects were inhibited by antioxidant vitamins and arachidonic acid metabolite inhibitors in human intestinal smooth muscle cells isolated from the bowels of Crohn's disease patients. The main pathological feature of Crohn's disease is an infiltration of polymorphonuclear neutrophils and mononuclear cells into the affected part of the intestine. Activated neutrophils produce noxious substances that cause inflammation and tissue injury. Due to the physiological and biochemical actions of reactive oxygen species and lipid peroxides, many of the clinical and pathophysiological features of Crohn's disease might be explained by an imbalance of increased reactive oxygen species and a net decrease of antioxidant molecules."

According to the news editors, the research concluded: "This review describes the general concepts of free radical, lipid peroxide and antioxidant activities and eventually illustrates their interferences in the development of Crohn's strictures."

For more information on this research see: Concepts of oxidative stress and antioxidant defense in Crohn's disease. World Journal of Gastroenterology, 2013;19(39):6540-6547. World Journal of Gastroenterology can be contacted at: Baishideng Publ Grp Co Ltd, Room 1701, 17-F, Henan Building, No. 90, Jaffe Rd, Wanchai, Hong Kong 100025, Peoples R China. (Baishideng Publishing Group -; World Journal of Gastroenterology -

The news editors report that additional information may be obtained by contacting M.A. Alzoghaibi, King Saud Univ, Coll Med, Dept. of Physiol, Riyadh 11461, Saudi Arabia (see also Inflammatory Bowel Diseases).

Keywords for this news article include: Asia, Antioxidants, Riyadh, Chalcogens, Immunology, Phagocytes, Blood Cells, Neutrophils, Saudi Arabia, Granulocytes, Free Radicals, Crohn's Disease, Gastroenteritis, Lipid Peroxides, Gastroenterology, Oxygen Compounds, Protective Agents, Reactive Oxygen Species, Hemic and Immune Systems, Digestive System Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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