By a News Reporter-Staff News Editor at Drug Week -- Research findings on Diabetes are discussed in a new report. According to news reporting originating in Shandong, People's Republic of China, by NewsRx journalists, research stated, "The study was performed to investigate the improved effect of curcumin on gastrointestinal function in streptozotocin-induced diabetic rats. Curcumin was administrated intragastrically at a dose of 100, 200 and 400 mg/kg/day to diabetic rats."
The news reporters obtained a quote from the research from Qingdao University, "After 28 days of treatment, the activity of superoxide dismutase (SOD), catalase (CAT), the content of reduced glutathione (GSH) and malondialdehyde (MDA) in gastric mucosa was assayed. Furthermore, the gastric function was evaluated by hormone secretion and gastric emptying tests. The results indicated that: (i) the diabetic rats exhibited significant decreases in the above mentioned antioxidative enzymes activities and GSH level and exhibited a high level of MDA. After administration of curcumin, the parameters were ameliorated to a large extent; (ii) curcumin treatment dose-dependently augmented the ghrelin levels of stomach and plasma, which were earlier depleted in the diabetic control rats. Conversely, the expression of ghrelin mRNA was decreased after curcumin treatment; and (iii) the gastric emptying in curcumin treated diabetic rats was notably accelerated compared with the diabetic control rats."
According to the news reporters, the research concluded: "These findings showed an improved effect of curcumin against streptozotocin-induced gastroparesis possibly by its antioxidant property."
For more information on this research see: Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. European Journal of Pharmacology, 2013;718(1-3):219-225. European Journal of Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmacology - www.elsevier.com/wps/product/cws_home/506087)
Our news correspondents report that additional information may be obtained by contacting L. Xu, Qingdao Univ, Coll Med, Dept. of Pathophysiol, Qingdao 266021, Shandong, People's Republic of China. Additional authors for this research include Z.L. Li and F.F. Guo (see also Diabetes).
Keywords for this news article include: Asia, Alkanes, Ghrelin, Shandong, Curcumin, Diabetes, Catechols, Treatment, Hydrocarbons, Endocrinology, Gastroparesis, Diarylheptanoids, Gastroenterology, Peptide Hormones, Stomach Diseases, Organic Chemicals, Gastrointestinal Diseases, People's Republic of China
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