By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Researchers detail new data in Aromatic Amino Acids. According to news originating from Nashville, Tennessee, by NewsRx correspondents, research stated, "Scope: Ascorbic acid (ascorbate) is required to recycle tetrahydrobiopterin, which is necessary for neurotransmitter synthesis by the rate-limiting enzymes tyrosine and tryptophan hydroxylases. We sought to determine whether ascorbate might regulate embryonic brain cortex monoamine synthesis utilizing transgenic mouse models with varying intracellular ascorbate levels."
Our news journalists obtained a quote from the research from Vanderbilt University, "In embryos lacking the sodium-dependent vitamin C transporter 2 (SVCT2), very low levels of brain ascorbate decreased cortex levels of norepinephrine and dopamine by approximately 33%, but had no effect on cortex serotonin or its metabolite, 5-hydroxyindole acetic acid. This decrease in ascorbate also led to a decrease in protein levels of tyrosine hydroxylase, but not of tryptophan hydroxylase. Increased cortex ascorbate in embryos carrying extra copies of the SVCT2 resulted in increased levels of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), as well as serotonin and 5-hydroxyindole acetic acid."
According to the news editors, the research concluded: "The dependence of embryonic brain cortex neurotransmitter synthesis and tyrosine hydroxylase expression on intracellular ascorbate emphasizes the importance of receiving adequate ascorbate during development."
For more information on this research see: Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid. Brain Research, 2013;1539():7-14. Brain Research can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Brain Research - www.elsevier.com/wps/product/cws_home/622287)
The news correspondents report that additional information may be obtained from M.E. Meredith, Vanderbilt University, Dept. of Med, Div Endocrinol, Nashville, TN 37232, United States (see also Aromatic Amino Acids).
Keywords for this news article include: Tyrosine, Nashville, Tennessee, Hydroxylase, United States, Aromatic Amino Acids, Enzymes and Coenzymes, North and Central America
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