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New Findings in Chronic Kidney Disease Described from Division of Nephrology



By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Chronic Kidney Disease. According to news reporting originating in Bangkok, Thailand, by NewsRx journalists, research stated, "Vitamin D insufficiency is associated with proteinuria and could be a risk factor for end-stage renal disease (ESRD). However, few studies have examined the significance of vitamin D insufficiency as a contributing factor for the development of ESRD in the Asian chronic kidney disease (CKD) population."

The news reporters obtained a quote from the research from the Division of Nephrology, "Authors examined the relationship between vitamin D status and the staging of CKD using data from an outpatient clinic-based screening in 2,895 Thai CKD patients. Serum levels of 25-hydroxyvitamin D were analyzed according to CKD stages. Vitamin D deficiency and insufficiency were defined as a serum 25-hydroxyvitamin D concentration <10 ng/mL and 10-30 ng/mL, respectively. The mean (SD) 25-hydroxyvitamin D levels were significantly lower according to severity of renal impairment (CKD stage 3a: 27.84 ?? 14.03 ng/mL, CKD stage 3b: 25.86 ?? 11.14 ng/mL, CKD stage 4:24.09 ?? 11.65 and CKD stage 5:20.82 ?? 9.86 ng/mL, p<0.001). The prevalence of vitamin D deficiency/insufficiency was from CKD stage 3a, 3b, 4 to 5, 66.6%, 70.9%, 74.6%, and 84.7% (p <0.001). The odds ratio (95% CI) of vitamin D insufficiency/deficiency (serum 25-hydroxyvitamin D ? 30 ng/mL) and vitamin D deficiency (serum 25-hydroxyvitamin D<10 ng/mL) for developing ESRD, after adjustment for age, gender, hemoglobin, serum albumin, calcium, phosphate and alkaline phosphatase were 2.19 (95% CI 1.07 to 4.48) and 16.76 (95% CI 4.89 to 57.49), respectively."

According to the news reporters, the research concluded: "This study demonstrates that 25-hydroxyvitamin D insufficiency and deficiency are more common and associated with the level of kidney function in the Thai CKD population especially advanced stage of CKD."

For more information on this research see: Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population. Bmc Nephrology, 2013;14():206. (BioMed Central - www.biomedcentral.com/; Bmc Nephrology - www.biomedcentral.com/bmcnephrol/)

Our news correspondents report that additional information may be obtained by contacting B. Satirapoj, Division of Nephrology, Dept. of Medicine, Phramongkutklao Hospital, Bangkok, Thailand. Additional authors for this research include P. Limwannata, A. Chaiprasert, O. Supasyndh and P. Choovichian (see also Chronic Kidney Disease).

Keywords for this news article include: Bangkok, Thailand, Chronic Kidney Disease.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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