By a News Reporter-Staff News Editor at Drug Week -- Current study results on Health and Medicine have been published. According to news reporting originating from Oxford, United Kingdom, by NewsRx correspondents, research stated, "To examine the independent relevance of plasma concentrations of 25-hydroxyvitamin D [25(OH)D] for vascular and non-vascular mortality. We examined associations of plasma concentrations of 25(OH)D and cause-specific mortality in a prospective study of older men living in the UK and included findings in meta-analyses of similar studies identified by a systematic search reporting on vascular and all-cause mortality."
Our news editors obtained a quote from the research from the University of Oxford, "In a 13-year follow-up of 5409 men (mean baseline age 77 years), 1358 died from vascular and 1857 from non-vascular causes. Median season-adjusted baseline 25(OH)D concentration was 56 (interquartile range: 45-67) nmol/L. After adjustment for age and seasonality, higher concentrations of 25(OH)D were inversely and approximately linearly (log-log scale) associated with vascular and non-vascular mortality throughout the range 40-90 nmol/L. After additional adjustment for prior disease and cardiovascular risk factors, a doubling in 25(OH)D concentration was associated with 20% [95% confidence interval (CI): 9-30%] lower vascular and 23% (95% CI: 14-31%) lower non-vascular mortality. In meta-analyses of prospective studies, individuals in the top vs. bottom quarter of 25(OH)D concentrations had 21% (95% CI: 13-28%) lower vascular and 28% (95% CI: 24-32%) lower all-cause mortality. Despite strong inverse and apparently independent associations of 25(OH)D with vascular and non-vascular mortality, causality remains uncertain."
According to the news editors, the research concluded: "Large-scale randomized trials, using high doses of vitamin D, are required to assess the clinical relevance of these associations."
For more information on this research see: Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths. European Heart Journal, 2013;34(18):1365-74. (Oxford University Press - www.oup.com/; European Heart Journal - eurheartj.oxfordjournals.org)
The news editors report that additional information may be obtained by contacting J. Tomson, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK. Additional authors for this research include J. Emberson, M. Hill, A. Gordon, J. Armitage, M. Shipley, R. Collins and R. Clarke (see also Health and Medicine).
Keywords for this news article include: Oxford, Europe, United Kingdom, Health and Medicine, Clinical Trials and Studies.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .