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Researchers from University of Kansas Describe Findings in Clinical Trials and Studies


By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Researchers detail new data in Clinical Research. According to news reporting originating from Kansas City, Kansas, by NewsRx correspondents, research stated, "Alcohol dependence is associated with severe nutritional and vitamin deficiency. Vitamin B1 (thiamine) deficiency erodes neurological pathways that may influence the ability to drink in moderation."

Our news editors obtained a quote from the research from the University of Kansas, "The present study examines tolerability of supplementation using the high-potency thiamine analog, benfotiamine (BF), and BF's effects on alcohol consumption in severely affected, self-identified, alcohol dependent subjects. A randomized, double-blind, placebo-controlled trial was conducted on 120 non-treatment seeking, actively drinking, alcohol dependent men and women volunteers (mean age = 47 years) from the Kansas City area who met DSM-IV-TR criteria for current alcohol dependence. Subjects were randomized to receive 600 mg benfotiamine or placebo (PL) once daily by mouth for 24 weeks with 6 follow-up assessments scheduled at 4 week intervals. Side effects and daily alcohol consumption were recorded. Seventy (58%) subjects completed 24 weeks of study (N = 21 women; N = 49 men) with overall completion rates of 55% (N = 33) for PL and 63% (N = 37) for BF groups. No significant adverse events were noted and alcohol consumption decreased significantly for both treatment groups. Alcohol consumption decreased from baseline levels for 9 of 10 BF treated women after 1 month of treatment compared with 2 of 11 on PL. Reductions in total alcohol consumption over 6 months were significantly greater for BF treated women (BF: N = 10, -611 +/- 380 standard drinks; PL: N = 11, -159 +/- 562 standard drinks, p-value = 0.02). BF supplementation of actively drinking alcohol dependent men and women was well-tolerated and may discourage alcohol consumption among women."

According to the news editors, the research concluded: "The results do support expanded studies of BF treatment in alcoholism."

For more information on this research see: Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug and Alcohol Dependence, 2013;133(2):562-570. Drug and Alcohol Dependence can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier -; Drug and Alcohol Dependence -

The news editors report that additional information may be obtained by contacting A.M. Manzardo, University of Kansas, Medical Center, Dept. of Psychiat & Behav Sci, Kansas City, KS 66160, United States. Additional authors for this research include J.H. He, A. Poje, E.C. Penick, J. Campbell and M.G. Butler (see also Clinical Research).

Keywords for this news article include: Treatment, Alcoholism, Kansas City, United States, Mental Health, Clinical Research, Addiction Medicine, North and Central America, Clinical Trials and Studies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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