Life Extension Spring Clearance Sale

Daily News: Vitamins

Researchers from University of Kansas Describe Findings in Clinical Trials and Studies


NewsRx.com

01-10-14

By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Researchers detail new data in Clinical Research. According to news reporting originating from Kansas City, Kansas, by NewsRx correspondents, research stated, "Alcohol dependence is associated with severe nutritional and vitamin deficiency. Vitamin B1 (thiamine) deficiency erodes neurological pathways that may influence the ability to drink in moderation."

Our news editors obtained a quote from the research from the University of Kansas, "The present study examines tolerability of supplementation using the high-potency thiamine analog, benfotiamine (BF), and BF's effects on alcohol consumption in severely affected, self-identified, alcohol dependent subjects. A randomized, double-blind, placebo-controlled trial was conducted on 120 non-treatment seeking, actively drinking, alcohol dependent men and women volunteers (mean age = 47 years) from the Kansas City area who met DSM-IV-TR criteria for current alcohol dependence. Subjects were randomized to receive 600 mg benfotiamine or placebo (PL) once daily by mouth for 24 weeks with 6 follow-up assessments scheduled at 4 week intervals. Side effects and daily alcohol consumption were recorded. Seventy (58%) subjects completed 24 weeks of study (N = 21 women; N = 49 men) with overall completion rates of 55% (N = 33) for PL and 63% (N = 37) for BF groups. No significant adverse events were noted and alcohol consumption decreased significantly for both treatment groups. Alcohol consumption decreased from baseline levels for 9 of 10 BF treated women after 1 month of treatment compared with 2 of 11 on PL. Reductions in total alcohol consumption over 6 months were significantly greater for BF treated women (BF: N = 10, -611 +/- 380 standard drinks; PL: N = 11, -159 +/- 562 standard drinks, p-value = 0.02). BF supplementation of actively drinking alcohol dependent men and women was well-tolerated and may discourage alcohol consumption among women."

According to the news editors, the research concluded: "The results do support expanded studies of BF treatment in alcoholism."

For more information on this research see: Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug and Alcohol Dependence, 2013;133(2):562-570. Drug and Alcohol Dependence can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Drug and Alcohol Dependence - www.elsevier.com/wps/product/cws_home/506052)

The news editors report that additional information may be obtained by contacting A.M. Manzardo, University of Kansas, Medical Center, Dept. of Psychiat & Behav Sci, Kansas City, KS 66160, United States. Additional authors for this research include J.H. He, A. Poje, E.C. Penick, J. Campbell and M.G. Butler (see also Clinical Research).

Keywords for this news article include: Treatment, Alcoholism, Kansas City, United States, Mental Health, Clinical Research, Addiction Medicine, North and Central America, Clinical Trials and Studies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2014, Mental Health Weekly Digest via NewsRx.com

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

  • Consumer Alerts | Learn about issues that could impact your right to obtain the nutritional supplements and/or hormones such as DHEA that you depend on.

  • LEF Forum | Life Extension hosts Forums on Supplements, Hormones, Lifestyles, Disorders/Diseases, and other areas of interest to life extensionists worldwide.

  • What's Hot | News flashes are posted here frequently to keep you up-to-date with the latest advances in health care, nutritional supplements, and longevity.

  • Legislative Action Center | Take action on important current issues featured in Life Extension magazine and our web site.

  • Events | Find out about upcoming life extension related conferences, seminars, and meetings, or view reports on past events.

  • Life Extension Update | Our periodical newsletter reports new findings in longevity, preventive medicine and disease as soon as they are discovered!

  • Multimedia Center | An information-packed collection of video and audio featuring various health topics of importance to you.

Top 12 Steps For Achieving Ultimate Health