By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators discuss new findings in Cholesterol. According to news reporting from Karachi, Pakistan, by NewsRx journalists, research stated, "Since Pakistanis have high prevalence of hypovitaminosis-D as well as acute myocardial infarction (AMI), the objective of the study was to investigate the relationship between vitamin-D deficiency and risk of AMI in a hospital-based population and to identify major risk factors for this disease. Fasting serum samples from 66 consecutive AMI patients [age 30-70 y] and 132 gender and age-matched (within 5 y) healthy controls were analyzed for concentrations of glucose, total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium, inorganic phosphate, alkaline phosphatase (ALP), bone-ALP, parathyroid hormone (PTH), 25(OH) vitamin-D (25(OH)D) and alanine aminotransferase."
The news correspondents obtained a quote from the research from the National Institute of Cardiovascular Disease, "Mean concentrations of serum 25(OH)D, PTH, total-ALP, bone-ALP, LDL-cholesterol, HDL-cholesterol and glucose were significantly different compared to healthy controls (p < 0.05). Percent vitamin-D deficiency/insufficiency (levels < 30 ng/ml) was significantly greater in AMI patients compared to controls (93.9% vs.75.8%; p = 0.001). Multiple conditional logistic regression analysis revealed that increased levels of 25(OH)D were associated with decreased risk of AMI [MAOR (95% CI) = 0.821 (0.718, 0.940); p = 0.004]. Hypertension and smoking were positively associated with AMI. Increased vitamin-D levels were associated with decreased risk of AMI, while serum glucose, bone-ALP, hypertension and smoking were positively associated with it."
According to the news reporters, the research concluded: "Association of bone-ALP with AMI in hypovitaminosis-D is a novel finding of this study."
For more information on this research see: Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D. Clinica Chimica Acta, 2013;425():192-195. Clinica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Clinica Chimica Acta - www.elsevier.com/wps/product/cws_home/506018)
Our news journalists report that additional information may be obtained by contacting M.P. Iqbal, Natl Inst Cardiovasc Dis, Karachi, Pakistan. Additional authors for this research include N. Mehboobali, I. Azam and A.K. Tareen (see also Cholesterol).
Keywords for this news article include: Asia, Karachi, Pakistan, Cholesterol, Heart Attack, Bone Research, Heart Disease, Vascular Diseases, Myocardial Ischemia, Alkaline Phosphatase, Enzymes and Coenzymes, Acute Myocardial Infarction, Phosphoric Monoester Hydrolases
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