By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Diabetes are presented in a new report. According to news reporting from Esfahan, Iran, by NewsRx journalists, research stated, "To our knowledge, there is no study that has examined the effects of vitamin D supplementation on metabolic status in gestational diabetes mellitus (GDM). This study was designed to assess the effects of vitamin D supplementation on metabolic profiles, high-sensitivity C-reactive protein, and biomarkers of oxidative stress in pregnant women with GDM."
The news correspondents obtained a quote from the research from the Isfahan University of Medical Sciences, "This randomized, double-blind, placebo-controlled clinical trial was conducted in 54 women with GDM. Subjects were randomly assigned to receive either vitamin D supplements or placebo. Individuals in the vitamin D group (n = 27) received capsules containing 50,000 IU vitamin D-3 2 times during the study (at baseline and at day 21 of the intervention) and those in the placebo group (n = 27) received 2 placebos at the same times. Fasting blood samples were collected at baseline and after 6 wk of the intervention to quantify relevant variables. Cholecalciferol supplementation resulted in increased serum 25-hydroxyvitamin D concentrations compared with placebo (+18.5 +/- 20.4 compared with +0.5 +/- 6.1 ng/mL; P< 0.001). Furthermore, intake of vitamin D supplements led to a significant decrease in concentrations of fasting plasma glucose (-17.1 +/- 14.8 compared with -0.9 +/- 16.6 mg/dL; P< 0.001) and serum insulin (-3.08 +/- 6.62 compared with +1.34 +/- 6.51 mu IU/mL; P = 0.01) and homeostasis model of assessment-insulin resistance (-1.28 +/- 1.41 compared with +0.34 +/- 1.79; P< 0.001) and a significant increase in the Quantitative Insulin Sensitivity Check Index (+0.03 +/- 0.03 compared with -0.001 +/- 0.02; P = 0.003) compared with placebo. A significant reduction in concentrations of total (-11.0 +/- 23.5 compared with +9.5 +/- 36.5 mg/dL; P = 0.01) and low-density. lipoprotein (LDL) (-10.8 +/- 22.4 compared with +10.4 +/- 28.0 mg/dL; P = 0.003) cholesterol was also seen after vitamin D supplementation."
According to the news reporters, the research concluded: "Vitamin D supplementation in pregnant women with GDM had beneficial effects on glycemia and total and LDL-cholesterol concentrations but did not affect inflammation and oxidative stress."
For more information on this research see: Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. American Journal of Clinical Nutrition, 2013;98(6):1425-1432. American Journal of Clinical Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA (see also Diabetes).
Our news journalists report that additional information may be obtained by contacting Z. Asemi, Isfahan Univ Med Sci, Dept. of Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran. Additional authors for this research include T. Hashemi, M. Karamali, M. Samimi and A. Esmaillzadeh.
Keywords for this news article include: Iran, Asia, Esfahan, Pregnancy, Metabolism, Proinsulin, Inflammation, Peptide Hormones, Clinical Trials and Studies, Gestational Diabetes Mellitus
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