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Studies from Harvard University Provide New Data on Menopause


NewsRx.com

01-10-14

By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Fresh data on Menopause are presented in a new report. According to news originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Telomere length is a marker of cellular aging that varies with the individual, is inherited, and is highly correlated across somatic cell types within persons. Interindividual variability of telomere length may partly explain differences in reproductive aging rates."

Our news journalists obtained a quote from the research from Harvard University, "We examined whether leukocyte telomere length was associated with menopausal age. We evaluated the relationship between leukocyte telomere length and age at natural menopause in 486 white women 65 years of age. We fit linear regression models adjusted for age, income, education, body mass index, physical activity, smoking, and alcohol intake. We repeated the analysis in women with surgical menopause. We also performed sensitivity analyses excluding women (1) with unilateral oophorectomy, (2) who were nulliparous, or (3) reporting menopausal age <40 years, among other exclusions. For every 1-kb increase in leukocyte telomere length, average age at natural menopause increased by 10.2 months (95% confidence interval = 1.3 to 19.0). There was no association among 179 women reporting surgical menopause. In all but one sensitivity analysis, the association between leukocyte telomere length and age at menopause became stronger. However, when excluding women with menopausal age <40 years, the association decreased to 7.5 months (-0.4 to 15.5). Women with the longest leukocyte telomere length underwent menopause 3 years later than those with the shortest leukocyte telomere length. If an artifact, an association would likely also have been observed in women with surgical menopause."

According to the news editors, the research concluded: "If these results are replicated, leukocyte telomere length may prove to be a useful predictor of age at menopause."

For more information on this research see: Leukocyte Telomere Length and Age at Menopause. Epidemiology, 2014;25(1):139-146. Epidemiology can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Epidemiology - journals.lww.com/epidem/pages/default.aspx)

The news correspondents report that additional information may be obtained from K.E. Gray, Harvard University, Sch Dental Med, Dept. of Oral Hlth Policy & Epidemiol, Boston, MA 02115, United States. Additional authors for this research include M.A. Schiff, A.L. Fitzpatrick, M. Kimura, A. Aviv and J.R. Starr (see also Menopause).

Keywords for this news article include: Boston, Genetics, Telomere, Menopause, Immunology, Leukocytes, Blood Cells, Massachusetts, United States, Immune System, Women's Health, Intranuclear Space, Chromosome Structures, Cell Nucleus Structures, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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