We all lose some mental sharpness as we age, but men who drink heavily at
midlife can expect a steeper, faster decline in memory and thinking skills a
decade down the road, a new study suggests.
The study, published Wednesday in the journal Neurology, defines heavy drinking
for men as more than 36 grams of alcohol a day, the equivalent of 2.5 drinks.
Men who drink less or don't drink at all still lose some cognitive ground, the
researchers say, but not as much. The study looked at women but found no clear
The study suggests lighter drinking does not contribute to cognitive decline.
"The findings are in agreement with previous studies and suggest that moderate
alcohol con-sumption is probably not deleterious for cognitive outcomes," says
lead researcher Severine Sabia, an epidemiologist at University College-London.
Some studies even suggest light or moderate drinking might be better for aging
brains than abstinence, but the new study did not show that, she says. There was
a hint that non-drinking women fared worse than moderate drinkers, but there
were not enough abstaining women in the study to make the results convincing,
Sabia says. The study suggested faster cognitive declines for female heavy
drinkers, but those results were not statistically significant.
The study involved more than 5,000 men and 2,000 women, all white-collar
workers, participating in a long-running health study in the United Kingdom.
Starting at an average age of 45, the participants told researchers how much
they drank. A decade later, they started taking tests of memory and executive
function, the kind of thinking used in planning, organizing and regulating
Researchers found no major differences among men who abstained, quit drinking
during the study or had up to two drinks a day. The men who averaged 2.5 drinks
or more lost ground on memory tests at a rate nearly six years faster than other
men; they declined on executive function nearly two years faster.
It's important to note that some of the men in the heavy-drinking group drank as
many as eight drinks a day on average, says Sara Jo Nixon, a professor of
psychiatry at the University of Florida-Gainesville. It would be wrong to
assume, she says, that men who drink 2.5 drinks a day are at the same risk as
the heaviest drinkers.
In the USA, health officials define a drink as the amount in 12 ounces of beer,
5 ounces of wine or a 1.5-ounce shot of liquor, according to the Centers for
Disease Control and Prevention.
Moderate drinking is defined as up to two drinks a day for men, but just one
drink for women, because the same amount of alcohol typically affects women more
In addition to cognitive risks, drinking is associated with increased risks of
breast cancer in women and increases in car crashes, violence and liver disease.
Some evidence suggests moderate drinking is beneficial for heart health in some